MSK
Search
- Page Path
- HOME > Search
Review
- Replicating poxviruses for human cancer therapy
- Manbok Kim
- J. Microbiol. 2015;53(4):209-218. Published online April 8, 2015
- DOI: https://doi.org/10.1007/s12275-015-5041-4
- 53 View
- 0 Download
- 24 Crossref
-
Abstract
- Naturally occurring oncolytic viruses are live, replicationproficient viruses that specifically infect human cancer cells while sparing normal cell counterparts. Since the eradication of smallpox in the 1970s with the aid of vaccinia viruses, the vaccinia viruses and other genera of poxviruses have shown various degrees of safety and efficacy in pre-clinical or clinical application for human anti-cancer therapeutics. Furthermore, we have recently discovered that cellular tumor suppressor genes are important in determining poxviral oncolytic tropism. Since carcinogenesis is a multi-step process involving accumulation of both oncogene and tumor suppressor gene abnormalities, it is interesting that poxvirus can exploit abnormal cellular tumor suppressor signaling for its oncolytic specificity and efficacy. Many tumor suppressor genes such as p53, ATM, and RB are known to play important roles in genomic fidelity/maintenance. Thus, tumor suppressor gene abnormality could affect host genomic integrity and likely disrupt intact antiviral networks due to accumulation of genetic defects, which would in turn result in oncolytic virus susceptibility. This review outlines the characteristics of oncolytic poxvirus strains, including vaccinia, myxoma, and squirrelpox virus, recent progress in elucidating the molecular connection between oncogene/tumor suppressor gene abnormalities and poxviral oncolytic tropism, and the associated preclinical/clinical implications. I would also like to propose future directions in the utility of poxviruses for oncolytic virotherapy.
-
Citations
Citations to this article as recorded by
- Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy
Shashi Gujar, Jonathan G. Pol, Vishnupriyan Kumar, Manuela Lizarralde-Guerrero, Prathyusha Konda, Guido Kroemer, John C. Bell
Nature Protocols.2024; 19(9): 2540. CrossRef - A Comparative Study of Oncolytic Vaccinia Viruses Harboring Different Marine Lectins in Breast Cancer Cells
Yanrong Zhou, Qianpeng Wang, Qi Ying, Xiaomei Zhang, Ting Ye, Kan Chen, Gongchu Li
Marine Drugs.2023; 21(2): 77. CrossRef - Poxvirus-driven human diseases and emerging therapeutics
Kritika Srinivasan Rajsri, Mana Rao
Therapeutic Advances in Infectious Disease.2022;[Epub] CrossRef - The O H system: A panorama view of the PPV-host interaction
Yongzhong Yu, Zhengxing Lian, Yudong Cui
Infection, Genetics and Evolution.2022; 98: 105220. CrossRef - Anti-Tumor Effects of MAPK-Dependent Tumor-Selective Oncolytic Vaccinia Virus Armed with CD/UPRT against Pancreatic Ductal Adenocarcinoma in Mice
Hajime Kurosaki, Motomu Nakatake, Teruhisa Sakamoto, Nozomi Kuwano, Masato Yamane, Kenta Ishii, Yoshiyuki Fujiwara, Takafumi Nakamura
Cells.2021; 10(5): 985. CrossRef - Oncolytic Vaccinia Virus Expressing White-Spotted Charr Lectin Regulates Antiviral Response in Tumor Cells and Inhibits Tumor Growth In Vitro and In Vivo
Xue Wang, Ningning Zhou, Tingting Liu, Xiaoyuan Jia, Ting Ye, Kan Chen, Gongchu Li
Marine Drugs.2021; 19(6): 292. CrossRef - Novel Oncolytic Virus Armed with Cancer Suicide Gene and Normal Vasculogenic Gene for Improved Anti-Tumor Activity
Su-Nam Jeong, So Young Yoo
Cancers.2020; 12(5): 1070. CrossRef - Oncolytic Virotherapy for Malignant Tumor: Current Clinical Status
Yuhui Zhang, Zhuoming Liu
Current Pharmaceutical Design.2020; 25(40): 4251. CrossRef - Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS–STING signalling
James B. Eaglesham, Youdong Pan, Thomas S. Kupper, Philip J. Kranzusch
Nature.2019; 566(7743): 259. CrossRef - Targeted therapy of human glioblastoma combining the oncolytic properties of parvovirus H-1 and attenuated strains of the vaccinia virus
A. V. Tkacheva, G. F. Sivolobova, A. A. Grazhdantseva, O. B. Shevelev, I. A. Razumov, E. L. Zavjalov, V. B. Loktev, G. V. Kochneva
Molecular Genetics Microbiology and Virology (Russian version).2019; 37(2): 83. CrossRef - Poxvirus oncolytic virotherapy
Lino E. Torres-Domínguez, Grant McFadden
Expert Opinion on Biological Therapy.2019; 19(6): 561. CrossRef - Targeted Therapy of Human Glioblastoma Combining the Oncolytic Properties of Parvovirus H-1 and Attenuated Strains of the Vaccinia Virus
A. V. Tkacheva, G. F. Sivolobova, A. A. Grazhdantseva, O. B. Shevelev, I. A. Razumov, E. L. Zavjalov, V. B. Loktev, G. V. Kochneva
Molecular Genetics, Microbiology and Virology.2019; 34(2): 140. CrossRef - Intra-tumoral delivery of CXCL11 via a vaccinia virus, but not by modified T cells, enhances the efficacy of adoptive T cell therapy and vaccines
Edmund K. Moon, Liang-Chuan S. Wang, Kheng Bekdache, Rachel C. Lynn, Albert Lo, Stephen H. Thorne, Steven M. Albelda
OncoImmunology.2018; 7(3): e1395997. CrossRef - Development of improved therapeutic mesothelin-based vaccines for pancreatic cancer
Michael White, Andrew Freistaedter, Gwendolyn J. B. Jones, Emmanuel Zervos, Rachel L. Roper, Aamir Ahmad
PLOS ONE.2018; 13(2): e0193131. CrossRef - Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol
Rutger David Luteijn, Ingo Drexler, Geoffrey L. Smith, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz
Journal of General Virology.2018; 99(6): 790. CrossRef - Oncolytic viruses: emerging options for the treatment of breast cancer
Yogesh R. Suryawanshi, Tiantian Zhang, Karim Essani
Medical Oncology.2017;[Epub] CrossRef - Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef - Oncolytic virus efficiency inhibited growth of tumour cells with multiple drug resistant phenotype in vivo and in vitro
Elena P. Goncharova, Julia S. Ruzhenkova, Ivan S. Petrov, Sergey N. Shchelkunov, Marina A. Zenkova
Journal of Translational Medicine.2016;[Epub] CrossRef - Oncolytic virotherapy for urological cancers
Zahid Delwar, Kaixin Zhang, Paul S. Rennie, William Jia
Nature Reviews Urology.2016; 13(6): 334. CrossRef - Features of the Antitumor Effect of Vaccinia Virus Lister Strain
Evgeniy Zonov, Galina Kochneva, Anastasiya Yunusova, Antonina Grazhdantseva, Vladimir Richter, Elena Ryabchikova
Viruses.2016; 8(1): 20. CrossRef - Single-particle characterization of oncolytic vaccinia virus by flow virometry
Vera A. Tang, Tyler M. Renner, Oliver Varette, Fabrice Le Boeuf, Jiahu Wang, Jean-Simon Diallo, John C. Bell, Marc-André Langlois
Vaccine.2016; 34(42): 5082. CrossRef - Use of Reporter Genes in the Generation of Vaccinia Virus-Derived Vectors
Sally Al Ali, Sara Baldanta, Mercedes Fernández-Escobar, Susana Guerra
Viruses.2016; 8(5): 134. CrossRef - Naturally occurring reoviruses for human cancer therapy
Manbok Kim
BMB Reports.2015; 48(8): 454. CrossRef - Reoviral Oncotropism Against c-Myc Overexpressing HS 68 Cells
Manbok Kim
Journal of Bacteriology and Virology.2015; 45(2): 126. CrossRef
- Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy
Research Support, Non-U.S. Gov't
- NOTE] Isolation and Characterization of Self-Fertile Suppressors from the Sterile nsdD Deletion Mutant of Aspergillus nidulans
- Dong-Beom Lee , Lee Han Kim , Jin-Pyo Kim , Kap-Hoon Han , Dong-Min Han
- J. Microbiol. 2011;49(6):1054-1057. Published online December 28, 2011
- DOI: https://doi.org/10.1007/s12275-011-1111-4
- 26 View
- 0 Download
- 3 Scopus
-
Abstract
- To identify downstream and/or interactive factors of the nsdD gene, which encodes a positive regulator of sexual development of Aspergillus nidulans, suppressor mutants displaying a self-fertile phenotype were isolated from a sterile nsdD deletion mutant. At least five different loci (sndA-E) were identified and genetically analyzed. In the nsdD+ background, most of the suppressors showed a marked increment of sexual development, even under the stress conditions that normally inhibited sexual development. The common phenotype of the suppressor mutants suggested the involvement of the snd genes in the negative regulation of sexual development in response to the environmental factors.
- Novel strategy for isolating suppressors of meiosis-deficient mutants and its application for isolating the bcy1 suppressor
- Shin, Deug Yong , Yun, Jean Ho , Yoo, Hyang Sook
- J. Microbiol. 1997;35(1):61-65.
- 37 View
- 0 Download
-
Abstract
- A novel strategy was developed for isolating suppressors from sporulation-deficient mutants. The mutation in the BCY1 gene, which codes for the regulatory subunit of cAMP-dependent protein kinase, when homozygous, results in diploids being meiosis and sporulation deficient. Two plasmids, YCp-MATα and YEp-SPOT7-lacZ, were introduced into MATα BCY1^+ or MATα bcy1 haploid cells. The transformant of the BCY1^+ haploid cell produced β-galactosidase under nutrient starvation, but the bcy1 transformant did not. Using this system, the mutagenesis experiment performed on the bcy1 transformant strain resulted in a number of sporulation mutants that produced β-galactosidase under nutrient starvation. One complementation group, sob1, was identified from the isolated suppressor mutants and characterized as a single recessive mutation by tetrad analysis. Genetic analysis revealed that the sob1 mutation suppressed the sporulation deficiency, the failure to arrest at the G1 phase of the cell cycle, and the sensitivity to heat or nitrogen starvation caused by the bcy1 mutation. However, the sob1 mutation did not suppress the sporulation deficiency of ime1 and of ime2 diploids. These results suggest that the sob1 mutation affects a gene which functions as a downstream regulator in both meiosis and cell cycle regulation.
First
Prev
TOP
