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- Lactobacillus gasseri BNR17 and Limosilactobacillus fermentum ABF21069 Ameliorate High Sucrose-Induced Obesity and Fatty Liver via Exopolysaccharide Production and β-oxidation
- Yu Mi Jo, Yoon Ji Son, Seul-Ah Kim, Gyu Min Lee, Chang Won Ahn, Han-Oh Park, Ji-Hyun Yun
- J. Microbiol. 2024;62(10):907-918. Published online October 17, 2024
- DOI: https://doi.org/10.1007/s12275-024-00173-6
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Abstract
- Obesity and metabolic dysfunction-associated fatty liver disease (MAFLD) are prevalent metabolic disorders with substantial global health implications that are often inadequately addressed by current treatments and may have side effects. Probiotics have emerged as promising therapeutic agents owing to their beneficial effects on gut health and metabolism. This study investigated the synergistic effects of a probiotic combination of BNR17 and ABF21069 on obesity and MAFLD in C57BL/6 mice fed a high-sucrose diet. The probiotic combination significantly reduced body weight and fat accumulation compared with the high-sucrose diet. It also alleviated elevated serum leptin levels induced by a high-sucrose diet. Histological analysis revealed a significant reduction in white adipose tissue and fatty liver in the mice treated with the probiotic combination. Furthermore, increased expression of genes related to β-oxidation, thermogenesis, and lipolysis suggested enhanced metabolic activity. The probiotic groups, particularly the BNR17 group, showed an increase in fecal exopolysaccharides, along with a tendency toward a lower expression of intestinal sugar transport genes, indicating reduced sugar absorption. Additionally, inflammatory markers in the liver tissue exhibited lower expression in the ABF21069 group than in the HSD group. Despite each strain in the combination group having distinct characteristics and functions, their combined effect demonstrated synergy in mitigating obesity and MAFLD, likely through the modulation of fecal exopolysaccharides content and improvement in lipid metabolism. These findings underscore the potential of probiotic supplementation as a promising assistant therapy for managing obesity and MAFLD and provide valuable insights into its therapeutic mechanisms in metabolic disorders.
- Expansion of antibacterial spectrum of xanthorrhizol against Gram-negatives in combination with PMBN and food-grade antimicrobials
- Man Su Kim , Ha-Rim Kim , Haebom Kim , Soo-Keun Choi , Chang-Hwan Kim , Jae-Kwan Hwang , Seung-Hwan Park
- J. Microbiol. 2019;57(5):405-412. Published online February 22, 2019
- DOI: https://doi.org/10.1007/s12275-019-8511-2
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- 6 Web of Science
- 5 Crossref
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Abstract
- Xanthorrhizol (XTZ), isolated from Curcuma xanthorrhiza, has potent antifungal and antibacterial activity. It shows very strong activity against Gram-positive bacteria, such as Streptococcus mutans and Staphylococcus aureus, but is generally not active against Gram-negative bacteria. In this study, we explored the possibility of using a combination strategy for expanding the antimicrobial spectrum of XTZ against Gram-negative bacteria. To take advantage of XTZ being a food-grade material, 10 food-grade or generally recognized as safe (GRAS) antimicrobial compounds with low toxicities were selected for combination therapy. In addition, polymyxin B nonapeptide (PMBN), which is less toxic than polymyxin B, was also selected as an outer membrane permeabilizer. The antibacterial activity of various double or triple combinations with or without XTZ were assayed in vitro against four Gram-negative bacterial species (Escherichia coli, Salmonella enterica serovar Typhi, Salmonella enterica serovar Typhimurium, and Vibrio cholerae), with synergistic combinations exhibiting clear activity subjected to further screening. The combinations with the greatest synergism were XTZ + PMBN + nisin, XTZ + PMBN + carvacrol, and XTZ + PMBN + thymol. These combinations also showed potent antimicrobial activity against Shigella spp., Yersinia enterocolitica, and Acinetobacter baumannii. In time-kill assays, the three combinations achieved complete killing of E. coli within 2 h, and S. Typhi and V. cholera within 15 min. This is the first report on expanding the activity spectrum of XTZ against Gram-negative bacteria through combination with PMBN and food-grade or GRAS substances, with the resulting findings being particularly useful for increasing the industrial and medical applications of XTZ.
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Citations
Citations to this article as recorded by
- The efficacy of the food-grade antimicrobial xanthorrhizol against Staphylococcus aureus is associated with McsL channel expression
Elena A. Mordukhova, Jongwan Kim, Haiyan Jin, Kyoung Tai No, Jae-Gu Pan
Frontiers in Microbiology.2024;[Epub] CrossRef - Bacillus velezensis HY19 as a sustainable preservative in post-harvest citrus (Citrus reticulata Blanco L.) fruit management
Suping Li, Jingyu Hu, Shiqi Ning, Wei Li, Ru Jiang, Jianguo Huang, Yong Li
Food Control.2024; 155: 110068. CrossRef - Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health
Muhammad Amirul Amil, Syarifah Nur Syed Abdul Rahman, Lee Fah Yap, Fathilah Abdul Razak, Marina Mohd Bakri, Lamis S. O. Salem, Xiu Yi Lim, Nur Athirah Reduan, Kae Shin Sim
Chemistry & Biodiversity.2024;[Epub] CrossRef - Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa
Kylen E. Ridyard, Mariam Elsawy, Destina Mattrasingh, Darien Klein, Janine Strehmel, Carole Beaulieu, Alex Wong, Joerg Overhage
Antibiotics.2023; 12(2): 389. CrossRef - Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery
Gina Porras, François Chassagne, James T. Lyles, Lewis Marquez, Micah Dettweiler, Akram M. Salam, Tharanga Samarakoon, Sarah Shabih, Darya Raschid Farrokhi, Cassandra L. Quave
Chemical Reviews.2021; 121(6): 3495. CrossRef
- The efficacy of the food-grade antimicrobial xanthorrhizol against Staphylococcus aureus is associated with McsL channel expression
- Synergistic Antibacterial Effect between Silybin and N,N’-Dicyclohexylcarbodiimide in Clinical Pseudomonas aeruginosa Isolates
- Hyun Jun Jung , Dong Gun Lee
- J. Microbiol. 2008;46(4):462-467. Published online August 31, 2008
- DOI: https://doi.org/10.1007/s12275-008-0138-7
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- 20 Crossref
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Abstract
- Silybin is a composition of the silymarin group as a hepatoprotective agent, and it exhibits various biological activities, including an antibacterial activity. In this study, the effects of a combination of silybin with N,N′-dicyclohexylcarbodiimide (DCCD) against clinical isolates of Pseudomonas aeruginosa were investigated. In the results of susceptibility assay, silybin showed more potent antibacterial activity in methicilin-resistant Staphylococcus aureus (MRSA) than in P. aeruginosa, but DCCD significantly increased the antibacterial activity of silybin in P. aeruginosa. The antibacterial activity of silybin was affected by the strong action of multidrug-resistant pumps rather than by a permeable disruption of lipopolysaccharide and silybin showed a remarkable synergistic activity in combination with some antibiotic agents against drug-resistant bacteria. Therefore, silybin has a potential as a combination therapeutic agent for treatment of infectious diseases by multidrug-resistant bacteria.
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Citations
Citations to this article as recorded by- Metabolic labeling of peptidoglycan enabled optical analysis of probiotic vitality
Xinping Hu, Qirong Xiong, Shuai Hou, Hongwei Duan
Analytical Methods.2024; 16(36): 6164. CrossRef - A Comprehensive Review on the Antibacterial, Antifungal, Antiviral, and Antiparasitic Potential of Silybin
José Lima Pereira-Filho, Amanda Graziela Gonçalves Mendes, Carmem Duarte Lima Campos, Israel Viegas Moreira, Cinara Regina Aragão Vieira Monteiro, Suzany Hellen da Silva Soczek, Elizabeth Soares Fernandes, Rafael Cardoso Carvalho, Valério Monteiro-Neto
Antibiotics.2024; 13(11): 1091. CrossRef - Antibacterial, Antibiofilm, and Antioxidant Activity of 15 Different Plant-Based Natural Compounds in Comparison with Ciprofloxacin and Gentamicin
Ali Pormohammad, Dave Hansen, Raymond J. Turner
Antibiotics.2022; 11(8): 1099. CrossRef - BENEFICIAL EFFECTS OF SILYMARIN AGAINST NEPHROTOXICITY CAUSED BY SOME CHEMICALS
V. Ivanov, V. Slavova, D. Georgieva, V. Petrova-Tacheva, A. Tolekova
Trakia Journal of Sciences.2021; 19(2): 178. CrossRef - The Antibacterial Properties of 4, 8, 4′, 8′-Tetramethoxy (1,1′-biphenanthrene) -2,7,2′,7′-Tetrol from Fibrous Roots of Bletilla striata
Xue-Jiao Huang, Nan Xiong, Bo-Chen Chen, Fan Luo, Min Huang, Zhi-Shan Ding, Chao-Dong Qian
Indian Journal of Microbiology.2021; 61(2): 195. CrossRef - Discovery of natural products with metal-binding properties as promising antibacterial agents
Prasad Dandawate, Subhash Padhye, Rainer Schobert, Bernhard Biersack
Expert Opinion on Drug Discovery.2019; 14(6): 563. CrossRef - Antibacterial activity of oxyresveratrol against methicillin-resistant Staphylococcus aureus and its mechanism
Dae-Ki Joung, Su-Hyun Mun, Sung-Hoon Choi, Ok-Hwa Kang, Sung-Bae Kim, Young-Seob Lee, Tian Zhou, Ryong Kong, Jang-Gi Choi, Dong-Won Shin, Youn-Chul Kim, Dong-Sung Lee, Dong-Yeul Kwon
Experimental and Therapeutic Medicine.2016; 12(3): 1579. CrossRef - The Mechanism Underlying the Antibacterial Activity of Shikonin against Methicillin-ResistantStaphylococcus aureus
Young-Seob Lee, Dae-Young Lee, Yeon Bok Kim, Sang-Won Lee, Seon-Woo Cha, Hong-Woo Park, Geum-Soog Kim, Dong-Yeul Kwon, Min-Ho Lee, Sin-Hee Han
Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef - Antibacterial Effect of Haedokgeumhwa-san against Methicillin-Resistant Staphylococcus aureus
Ha-Il Lee, Su-Kyung Lee, Young-Mi Kwon, Yung-Sun Song
Journal of Korean Medicine Rehabilitation.2015; 25(2): 1. CrossRef - The Antibacterial Assay of Tectorigenin with Detergents or ATPase Inhibitors against Methicillin‐Resistant Staphylococcus aureus
Dae-Ki Joung, Su-Hyun Mun, Kuang-Shim Lee, Ok-Hwa Kang, Jang-Gi Choi, Sung-Bae Kim, Ryong Gong, Myong-Soo Chong, Youn-Chul Kim, Dong-Sung Lee, Dong-Won Shin, Dong-Yeul Kwon, José Luis Ríos
Evidence-Based Complementary and Alternative Medicine.2014;[Epub] CrossRef - Methyl Gallate from Galla rhois Successfully Controls Clinical Isolates of Salmonella Infection in Both In Vitro and In Vivo Systems
Jang-Gi Choi, Su-Hyun Mun, Harendra S. Chahar, Preeti Bharaj, Ok-Hwa Kang, Se-Gun Kim, Dong-Won Shin, Dong-Yeul Kwon, Herbert B. Tanowitz
PLoS ONE.2014; 9(7): e102697. CrossRef - In vitro anti-MRSA activity of carvone with gentamicin
SU-HYUN MUN, OK-HWA KANG, DAE-KI JOUNG, SUNG-BAE KIM, JANG-GI CHOI, DONG-WON SHIN, DONG-YEUL KWON
Experimental and Therapeutic Medicine.2014; 7(4): 891. CrossRef - Curcumin Reverse Methicillin Resistance in Staphylococcus aureus
Su-Hyun Mun, Sung-Bae Kim, Ryong Kong, Jang-Gi Choi, Youn-Chul Kim, Dong-Won Shin, Ok-Hwa Kang, Dong-Yeul Kwon
Molecules.2014; 19(11): 18283. CrossRef - The Mechanism of Antimicrobial Activity of Sophoraflavanone B Against Methicillin-ResistantStaphylococcus aureus
Su-Hyun Mun, Dae-Ki Joung, Sung-Bae Kim, Sung-Joo Park, Yun-Soo Seo, Ryong Gong, Jang-Gi Choi, Dong-Won Shin, Jung-Rae Rho, Ok-Hwa Kang, Dong-Yeul Kwon
Foodborne Pathogens and Disease.2014; 11(3): 234. CrossRef - The Mechanism of Antibacterial Activity of Tetrandrine AgainstStaphylococcus aureus
Young-Seob Lee, Sin-Hee Han, Su-Hwan Lee, Young-Guk Kim, Chung-Berm Park, Ok-Hwa Kang, Joon-Ho Keum, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Noh-Yil Myung, Dong-Yeul Kwon
Foodborne Pathogens and Disease.2012; 9(8): 686. CrossRef - Synergistic effects between silver nanoparticles and antibiotics and the mechanisms involved
In-sok Hwang, Ji Hong Hwang, Hyemin Choi, Keuk-Jun Kim, Dong Gun Lee
Journal of Medical Microbiology.2012; 61(12): 1719. CrossRef - Synergistic effect of tetrandrine and ethidium bromide against methicillin-resistant Staphylococcus aureus (MRSA)
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The Journal of Toxicological Sciences.2011; 36(5): 645. CrossRef - Synergistic effects between silibinin and antibiotics on methicillin‐resistant Staphylococcus aureus isolated from clinical specimens
Hyun‐Kyung Kang, Hye‐Young Kim, Jeong‐Dan Cha
Biotechnology Journal.2011; 6(11): 1397. CrossRef - The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus
Brice W Obiang-Obounou, Ok-Hwa Kang, Jang-Gi Choi, Joon-Ho Keum, Sung-Bae Kim, Su-Hyun Mun, Dong-Won Shin, Ki Woo Kim, Chung-Berm Park, Young-Guk Kim, Sin-Hee Han, Dong-Yeul Kwon
The Journal of Toxicological Sciences.2011; 36(3): 277. CrossRef - HETRBAL PREPARATIONS FROM MILK THISTLE: MECHANISMS OF ACTION AND APPLICATION IN LIVER DISEASES
Y. I. Brel, A. A. Lyzikov, E. S. Pitkevich
Health and Ecology Issues.2009; (4): 36. CrossRef
- Metabolic labeling of peptidoglycan enabled optical analysis of probiotic vitality
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