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Potential of 2, 2'-dipyridyl diselane as an adjunct to antibiotics to manage cadmium-induced antibiotic resistance in Salmonella enterica serovar Typhi Ty2 strain
Praveen Rishi , Reena Thakur , Ujjwal Jit Kaur , Harjit Singh , Kuldip K. Bhasin
J. Microbiol. 2017;55(9):737-744.   Published online August 5, 2017
DOI: https://doi.org/10.1007/s12275-017-7040-0
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  • 5 Crossref
AbstractAbstract
One of the reasons for increased antibiotic resistance in Salmonella enterica serovar Typhi Ty2 is the influx of heavy metal ions in the sewage, from where the infection is transmitted. Therefore, curbing these selective agents could be one of the strategies to manage the emergence of multidrug resistance in the pathogen. As observed in our earlier study, the present study also confirmed the links between cadmium accumulation and antibiotic resistance in Salmonella. Therefore, the potential of a chemically-synthesised compound 2, 2􍿁-dipyridyl diselane (DPDS) was explored to combat the metal-induced antibiotic resistance. Its metal chelating and antimicrobial properties were evidenced by fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FE-SEM), and microbroth dilution
method
. Owing to these properties of DPDS, further, this compound was evaluated for its potential to be used in combination with conventional antibiotics. The data revealed effective synergism at much lower concentrations of both the agents. Thus, it is indicated from the study that the combination of these two agents at their lower effective doses might reduce the chances of emergence of antibiotic resistance, which can be ascribed to the multi-pronged action of the agents.

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  • A NiCoT family metal transporter of Mycobacterium tuberculosis (Rv2856/NicT) behaves as a drug efflux pump that facilitates cross-resistance to antibiotics
    Anwesha Adhikary, Sarmistha Biswal, Debasmita Chatterjee, Anindya S. Ghosh
    Microbiology .2022;[Epub]     CrossRef
  • Heavy metal-induced selection and proliferation of antibiotic resistance: A review
    Prakriti Vats, Ujjwal Jit Kaur, Praveen Rishi
    Journal of Applied Microbiology.2022; 132(6): 4058.     CrossRef
  • Potential of 1-(1-napthylmethyl)-piperazine, an efflux pump inhibitor against cadmium-induced multidrug resistance in Salmonella enterica serovar Typhi as an adjunct to antibiotics
    Ujjwal Jit Kaur, Adity Chopra, Simran Preet, Khem Raj, Kanthi Kiran Kondepudi, Varsha Gupta, Praveen Rishi
    Brazilian Journal of Microbiology.2021; 52(3): 1303.     CrossRef
  • Prophylactic potential of cytolethal distending toxin B (CdtB) subunit of typhoid toxin against Typhoid fever
    Reena Thakur, Preeti Pathania, Navneet Kaur, Vattan Joshi, Kanthi Kiran Kondepudi, Chander Raman Suri, Praveen Rishi
    Scientific Reports.2019;[Epub]     CrossRef
  • Augmented antibiotic resistance associated with cadmium induced alterations in Salmonella enterica serovar Typhi
    Ujjwal Jit Kaur, Simran Preet, Praveen Rishi
    Scientific Reports.2018;[Epub]     CrossRef
The in vitro and in vivo efficacy of fluconazole in combination with farnesol against Candida albicans isolates using a murine vulvovaginitis model
Aliz Bozó , Marianna Domán , László Majoros , Gábor Kardos , István Varga , Renátó Kovács
J. Microbiol. 2016;54(11):753-760.   Published online October 29, 2016
DOI: https://doi.org/10.1007/s12275-016-6298-y
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AbstractAbstract
Farnesol is a quorum-sensing molecule that inhibits biofilm formation in Candida albicans. Previous in vitro data suggest that, in combination with certain antifungals, farnesol may have an adjuvant anti-biofilm agent. However, the in vivo efficacy of farnesol is very questionable. Therefore, the in vitro and in vivo activity of fluconazole combined with farnesol was evaluated against C. albicans biofilms using fractional inhibitory concentration index (FICI) determination, time-kill experiments and a murine vulvovaginitis model. The median biofilm MICs of fluconazole-sensitive C. albicans isolates ranged between 4 -> 512 mg/L and 150–300 μM for fluconazole and farnesol, respectively. These values were 512 -> 512 mg/L and > 300 μM for fluconazole-resistant clinical isolates. Farnesol decreased the median MICs of fluconazole by 2-64-fold for biofilms. Based on FICI, synergistic interaction was observed only in the case of the sessile SC5314 reference strain (FICIs: 0.16–0.27). In time-kill studies, only the 512 mg/L fluconazole and 512 mg/L fluconazole + 75 μM farnesol reduced biofilm mass significantly at each time point in the case of all isolates. The combination reduced the metabolic activity of biofilms for all isolates in a concentration- and time-dependent manner. Our findings revealed that farnesol alone was not protective in a murine vulvovaginitis model. Farnesol was not beneficial in combination with fluconazole for fluconazole-susceptible isolates, but partially increased fluconazole activity against one fluconazole- resistant isolate, but not the other one.

Citations

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  • Exploring the Potential of Farnesol as a Novel Antifungal Drug and Related Challenges
    Dongming Zheng, Linlan Yang, Yuxin Bai, Jiangyan Yong, Yan Li
    Current Infectious Disease Reports.2024; 26(4): 123.     CrossRef
  • Total transcriptome response for tyrosol exposure in Aspergillus nidulans
    Ágnes Jakab, Kinga Csillag, Károly Antal, Imre Boczonádi, Renátó Kovács, István Pócsi, Tamás Emri
    Fungal Biology.2024; 128(2): 1664.     CrossRef
  • Combination of Farnesol with Common Antifungal Drugs: Inhibitory Effect against Candida Species Isolated from Women with RVVC
    Fatemeh Nikoomanesh, Mahsa Falahatinejad, Lucia Černáková, André Luis Souza dos Santos, Shahla Roudbar Mohammadi, Mitra Rafiee, Célia Fortuna Rodrigues, Maryam Roudbary
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  • Antifungal Activity and Type of Interaction of Melissa officinalis Essential Oil with Antimycotics against Biofilms of Multidrug-Resistant Candida Isolates from Vulvovaginal Mucosa
    Marina Ranđelović, Marina Dimitrijević, Suzana Otašević, Ljiljana Stanojević, Milica Išljamović, Aleksandra Ignjatović, Valentina Arsić-Arsenijević, Zorica Stojanović-Radić
    Journal of Fungi.2023; 9(11): 1080.     CrossRef
  • Application of natamycin and farnesol as bioprotection agents to inhibit biofilm formation of yeasts and foodborne bacterial pathogens in apple juice processing lines
    María del Rosario Agustín, María Clara Tarifa, María Soledad Vela-Gurovic, Lorena Inés Brugnoni
    Food Microbiology.2023; 109: 104123.     CrossRef
  • Hexyl-Aminolevulinate Ethosomes: a Novel Antibiofilm Agent Targeting Zinc Homeostasis in Candida albicans
    Yingzhe Wang, Wei Long, Feiyin Zhang, Meimei Zhang, Kang Zeng, Xiaoliang Zhu, Gustavo H. Goldman
    Microbiology Spectrum.2022;[Epub]     CrossRef
  • Farnesol Boosts the Antifungal Effect of Fluconazole and Modulates Resistance in Candida auris through Regulation of the CDR1 and ERG11 Genes
    Jaroslava Dekkerová, Lucia Černáková, Samuel Kendra, Elisa Borghi, Emerenziana Ottaviano, Birgit Willinger, Helena Bujdáková
    Journal of Fungi.2022; 8(8): 783.     CrossRef
  • Application of Natamycin and Farnesol as Biocontrol Agents of Multi-Species Biofilms on Industrial Surfaces in Apple Juice
    María del Rosario Agustín, Maria Clara Tarifa, Maria Soledad Vela-Gurovic, Lorena Ines Brugnoni
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Transcriptional Profiling of the Candida auris Response to Exogenous Farnesol Exposure
    Ágnes Jakab, Noémi Balla, Ágota Ragyák, Fruzsina Nagy, Fruzsina Kovács, Zsófi Sajtos, Zoltán Tóth, Andrew M. Borman, István Pócsi, Edina Baranyai, László Majoros, Renátó Kovács, Aaron P. Mitchell
    mSphere.2021;[Epub]     CrossRef
  • Farnesol: An approach on biofilms and nanotechnology
    Adelaide Fernandes Costa, Lívia do Carmo Silva, Andre Correa Amaral
    Medical Mycology.2021; 59(10): 958.     CrossRef
  • Modulating the Antifungal Activity of Antimycotic Drugs with Farnesol
    N. P. Sachivkina, A. N. Senyagin, I. V. Podoprigora, D. G. Brown, V. V. Vissarionova
    Drug development & registration.2021; 10(4): 162.     CrossRef
  • In vivo antifungal activities of farnesol combined with antifungal drugs against murine oral mucosal candidiasis
    Chengxi Li, Zheng Xu, Siqi Liu, Yun Huang, Wei Duan, Xin Wei
    Biofouling.2021; 37(8): 818.     CrossRef
  • Analysis of biofilm formation bySporothrix schenckii
    Rocío Sánchez-Herrera, Lérida Liss Flores-Villavicencio, Juan Luis Pichardo-Molina, José Pedro Castruita-Domínguez, Xochilt Aparicio-Fernández, Myrna Sabanero López, Julio Cesar Villagómez-Castro
    Medical Mycology.2021; 59(1): 31.     CrossRef
  • Antifungal activity of farnesol incorporated in liposomes and associated with fluconazole
    Camila Fonseca Bezerra, José Geraldo de Alencar Júnior, Rosilaine de Lima Honorato, Antonia Thassya Lucas dos Santos, Josefa Carolaine Pereira da Silva, Taís Gusmão da Silva, Antonio Linkoln Alves Borges Leal, Janaína Esmeraldo Rocha, Thiago Sampaio de Fr
    Chemistry and Physics of Lipids.2020; 233: 104987.     CrossRef
  • Optimum Inhibition of Amphotericin-B-Resistant Candida albicans Strain in Single- and Mixed-Species Biofilms by Candida and Non-Candida Terpenoids
    Hidaya F. Z. Touil, Kebir Boucherit, Zahia Boucherit-Otmani, Ghalia Kohder, Mohamed Madkour, Sameh S. M. Soliman
    Biomolecules.2020; 10(2): 342.     CrossRef
  • In vitro and in vivo Effect of Exogenous Farnesol Exposure Against Candida auris
    Fruzsina Nagy, Eszter Vitális, Ágnes Jakab, Andrew M. Borman, Lajos Forgács, Zoltán Tóth, László Majoros, Renátó Kovács
    Frontiers in Microbiology.2020;[Epub]     CrossRef
  • Fungal Quorum-Sensing Molecules: A Review of Their Antifungal Effect against Candida Biofilms
    Renátó Kovács, László Majoros
    Journal of Fungi.2020; 6(3): 99.     CrossRef
  • Fungal infection models: Current progress ofex vivomethods
    Priscilla Maciel Quatrin, Daiane Flores Dalla Lana, Taís Fernanda Andrzejewski Kaminski, Alexandre Meneghello Fuentefria
    Mycoses.2019; 62(10): 860.     CrossRef
  • Effect of quorum sensing molecules and natamycin on biofilms of Candida tropicalis and other yeasts isolated from industrial juice filtration membranes
    M.d.R. Agustín, F.R. Viceconte, M.S. Vela Gurovic, A. Costantino, L.I. Brugnoni
    Journal of Applied Microbiology.2019; 126(6): 1808.     CrossRef
  • Farnesol inhibits planktonic cells and antifungal-tolerant biofilms of Trichosporon asahii and Trichosporon inkin
    Rossana de Aguiar Cordeiro, Lívia Maria Galdino Pereira, José Kleybson de Sousa, Rosana Serpa, Ana Raquel Colares Andrade, Fernando Victor Monteiro Portela, Antônio José de Jesus Evangelista, Jamille Alencar Sales, Ana Luiza Ribeiro Aguiar, Patrícia Bruna
    Medical Mycology.2019; 57(8): 1038.     CrossRef
  • In Vivo Applicability of Neosartorya fischeri Antifungal Protein 2 (NFAP2) in Treatment of Vulvovaginal Candidiasis
    Renátó Kovács, Jeanett Holzknecht, Zoltán Hargitai, Csaba Papp, Attila Farkas, Attila Borics, Lilána Tóth, Györgyi Váradi, Gábor K. Tóth, Ilona Kovács, Sandrine Dubrac, László Majoros, Florentine Marx, László Galgóczy
    Antimicrobial Agents and Chemotherapy.2019;[Epub]     CrossRef
  • Biofilms and vulvovaginal candidiasis
    Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Alberto Molares-Vila, Adriana López-Barcenas, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Elena Sánchez-Blanco, Roberto Arenas-Guzmán, Rigoberto Hernandez-Castro
    Colloids and Surfaces B: Biointerfaces.2019; 174: 110.     CrossRef
  • Photodynamic Inactivation Potentiates the Susceptibility of Antifungal Agents against the Planktonic and Biofilm Cells of Candida albicans
    Mu-Ching Huang, Mandy Shen, Yi-Jhen Huang, Hsiao-Chi Lin, Chin-Tin Chen
    International Journal of Molecular Sciences.2018; 19(2): 434.     CrossRef
  • Antimicrobial photodynamic therapy as a new approach for the treatment of vulvovaginal candidiasis: preliminary results
    Maria Eugênia Simões Onofre de Santi, Renato Araujo Prates, Cristiane Miranda França, Rúbia Garcia Lopes, Aline Silva Sousa, Luis Rodolfo Ferreira, Sandra Kalil Bussadori, Adjaci Uchoa Fernandes, Alessandro Melo Deana
    Lasers in Medical Science.2018; 33(9): 1925.     CrossRef
  • In vitro antifungal susceptibility patterns of planktonic and sessile Candida kefyr clinical isolates
    Fruzsina Nagy, Aliz Bozó, Zoltán Tóth, Lajos Daróczi, László Majoros, Renátó Kovács
    Medical Mycology.2018; 56(4): 493.     CrossRef
  • The Structure-Activity Relationship of Pterostilbene Against Candida albicans Biofilms
    Dan-Dan Hu, Ri-Li Zhang, Yong Zou, Hua Zhong, En-Sheng Zhang, Xiang Luo, Yan Wang, Yuan-Ying Jiang
    Molecules.2017; 22(3): 360.     CrossRef
  • Antifungal activity of tyrosol and farnesol used in combination against Candida species in the planktonic state or forming biofilms
    D.R. Monteiro, L.S. Arias, R.A. Fernandes, L.F. Deszo da Silva, M.O.V.F. de Castilho, T.O. da Rosa, A.P.M. Vieira, F.G. Straioto, D.B. Barbosa, A.C.B. Delbem
    Journal of Applied Microbiology.2017; 123(2): 392.     CrossRef
Review
REVIEW] Mechanisms of Synergy in Polymicrobial Infections
Justine L. Murray , Jodi L. Connell , Apollo Stacy , Keith H. Turner , Marvin Whiteley
J. Microbiol. 2014;52(3):188-199.   Published online March 1, 2014
DOI: https://doi.org/10.1007/s12275-014-4067-3
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AbstractAbstract
Communities of microbes can live almost anywhere and contain many different species. Interactions between members of these communities often determine the state of the habitat in which they live. When these habitats include sites on the human body, these interactions can affect health and disease. Polymicrobial synergy can occur during infection, in which the combined effect of two or more microbes on disease is worse than seen with any of the individuals alone. Powerful genomic methods are increasingly used to study microbial communities, including metagenomics to reveal the members and genetic content of a community and metatranscriptomics to describe the activities of community members. Recent efforts focused toward a mechanistic understanding of these interactions have led to a better appreciation of the precise bases of polymicrobial synergy in communities containing bacteria, eukaryotic microbes, and/or viruses. These studies have benefited from advances in the development of in vivo models of polymicrobial infection and modern techniques to profile the spatial and chemical bases of intermicrobial communication. This review describes the breadth of mechanisms microbes use to interact in ways that impact pathogenesis and techniques to study polymicrobial communities.

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