Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate

Eun-Kyoung Choi; Hye-Hyang Lee; Mi-Sun Kang; Byung-Gook Kim; Hoi-Soon Lim; Seon-Mi Kim; In-Chol Kang

doi:10.1007/s12275-009-0049-2

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Research Support, Non-U.S. Gov't
Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate: Eun-Kyoung Choi ¹, Hye-Hyang Lee ¹, Mi-Sun Kang ¹, Byung-Gook Kim ², Hoi-Soon Lim ², Seon-Mi Kim ², In-Chol Kang ^1,2; Journal of Microbiology 2010;48(1):40-43.
DOI: https://doi.org/10.1007/s12275-009-0049-2
Published online: March 11, 2010

¹Brain Korea 21 Program, Chonnam National University Dental School, Gwangju 500-757, Republic of Korea, ²Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea¹Brain Korea 21 Program, Chonnam National University Dental School, Gwangju 500-757, Republic of Korea, ²Dental Science Research Institute, Chonnam National University, Gwangju 500-757, Republic of Korea

Corresponding author: In-Chol Kang , Tel: +82-62-530-4851,

Received: 23 February 2009 • Accepted: 27 July 2009

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Abstract

Zinc has antimicrobial activity and zinc salts including zinc chloride (ZnCl2) have been used for the control of oral malodor. In this study, we hypothesized that pyrrolidine dithiocarbamate (PDTC), a zinc ionophore, may enhance antimicrobial efficacy of ZnCl2. The bactericidal effectiveness of ZnCl2 alone (0.5-8 mM) or in combination with PDTC (1 or 10 μM) was evaluated by in vitro short (1 h) time-killing assays against Fusobacterium nucleatum and Porphyromonas gingivalis. Only a slight viability decrease was observed with ZnCl2 or PDTC alone after 1-h incubation. By contrast, combination of ZnCl2 and PDTC could achieve a more than 100-fold viability reduction compared with ZnCl2 or PDTC alone in F. nucleatum and P. gingivalis. Therefore, PDTC greatly enhanced the bactericidal activity of ZnCl2 against the oral malodor-producing bacteria. These results suggest that use of PDTC may be useful for enhancing bactericidal activity of antimalodor regimens of zinc salts.

Keywords: oral malodor;zinc;pyrrolidine dithiocarbamate;bactericidal

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Potentiation of Bacterial Killing Activity of Zinc Chloride by Pyrrolidine Dithiocarbamate

J. Microbiol. 2010;48(1):40-43. Published online March 11, 2010

DOI: https://doi.org/10.1007/s12275-009-0049-2

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