Anti-HIV-1 Efficacy of Extracts from Medicinal Plants

Su-A Lee; Seong-Karp Hong; Chang-Il Suh; Mi-Hwa Oh; Jeong-Ho Park; Byoung-Wook Choi; Seung-Won Park; Soon-Young Paik

doi:10.1007/s12275-009-0176-9

Articles

Page Path: HOME > J. Microbiol > Volume 48(2); 2010 > Article

Research Support, Non-U.S. Gov't
Anti-HIV-1 Efficacy of Extracts from Medicinal Plants: Su-A Lee ¹, Seong-Karp Hong ¹, Chang-Il Suh ¹, Mi-Hwa Oh ¹, Jeong-Ho Park ², Byoung-Wook Choi ², Seung-Won Park ¹, Soon-Young Paik ¹; Journal of Microbiology 2010;48(2):249-252.
DOI: https://doi.org/10.1007/s12275-009-0176-9
Published online: May 1, 2010

¹Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea, ²Department of Applied Chemistry and Biotechnology, Hanbat National University, Daejeon 305-719, Republic of Korea

Corresponding author: Soon-Young Paik , Tel: +82-2-590-1225,

Received: 5 June 2009 • Accepted: 28 September 2009

prev next

85 Views
0 Download
13 Crossref
20 Scopus

Full Article

Abstract

The anti-HIV-1 activities of butanol, hexane, chloroform and water extracts from four widely used folk medicinal plants (Sophora flavescens, Tulipa edulis, Herba ephedra, and Pachyma hoelen Rumph) were evaluated in this study. The hexane extract of Pachyma hoelen Rumph, PH-4, showed effective inhibition against HIV-1. The 50% effective concentration (EC50) of PH-4 was 37.3 μg/ml in the p24 antigen assay and 36.8% in the HIV-1 recombinant RT activity test (at 200 μg/ml). In addition, the PH-4 showed the protective effect on the infected MT-4 cells, with a 58.2% rate of protection. The 50% cytotoxic concentration (CC50) of PH-4 was 100.6 μg/ml. These results suggest that PH-4 from Pachyma hoelen Rumph might be the candidate for the chemotherapy agent against HIV-1 infection with further study.

Keywords: Anti-HIV-1;aqueous extracts;folk medicine;medicinal plants;organic extracts

Figure & Data

References

Citations

Citations to this article as recorded by

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties
Daphne E. González-Juárez, Abraham Escobedo-Moratilla, Joel Flores, Sergio Hidalgo-Figueroa, Natalia Martínez-Tagüeña, Jesús Morales-Jiménez, Alethia Muñiz-Ramírez, Guillermo Pastor-Palacios, Sandra Pérez-Miranda, Alfredo Ramírez-Hernández, Joyce Trujillo
Molecules.2020; 25(14): 3283. CrossRef
Immune stimulatory and anti-HIV-1 potential of extracts derived from marine brown algae Padina tetrastromatica
Dinesh Subramaniam, Luke Elizabeth Hanna, Kuppusamy Maheshkumar, Karuppiah Ponmurugan, Naif Abdullah Al-Dhabi, P. Murugan
Journal of Complementary and Integrative Medicine.2020;[Epub] CrossRef
Physicochemical and antioxidant potential of polysaccharides sequentially extracted from Amana edulis
Yu-Hang Ji, Ai-Mei Liao, Ji-Hong Huang, Kiran Thakur, Xiao-Li Li, Zhao-Jun Wei
International Journal of Biological Macromolecules.2019; 131: 453. CrossRef
Role of medicinal plants in HIV/AIDS therapy
Umme Laila, Muhammad Akram, Mohammad Ali Shariati, Asif Mehmmod Hashmi, Naheed Akhtar, Imtiaz Mahmood Tahir, Aymen Owais Ghauri, Naveed Munir, Muhammad Riaz, Naheed Akhter, Ghazala Shaheen, Qamar Ullah, Rabia Zahid, Saeed Ahmad
Clinical and Experimental Pharmacology and Physiology.2019; 46(12): 1063. CrossRef
Sulfonated and sulfated chitosan derivatives for biomedical applications: A review
Syrine Dimassi, Nicolas Tabary, Feng Chai, Nicolas Blanchemain, Bernard Martel
Carbohydrate Polymers.2018; 202: 382. CrossRef
Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus
Bahare Salehi, Nanjangud Kumar, Bilge Şener, Mehdi Sharifi-Rad, Mehtap Kılıç, Gail Mahady, Sanja Vlaisavljevic, Marcello Iriti, Farzad Kobarfard, William Setzer, Seyed Ayatollahi, Athar Ata, Javad Sharifi-Rad
International Journal of Molecular Sciences.2018; 19(5): 1459. CrossRef
Identification of miRNAs Involved in Stolon Formation in Tulipa edulis by High-Throughput Sequencing
Zaibiao Zhu, Yuanyuan Miao, Qiaosheng Guo, Yunhao Zhu, Xiaohua Yang, Yuan Sun
Frontiers in Plant Science.2016;[Epub] CrossRef
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences
Enoche F. Oga, Shuichi Sekine, Yoshihisa Shitara, Toshiharu Horie
European Journal of Drug Metabolism and Pharmacokinetics.2016; 41(2): 93. CrossRef
A review of the relaxant effect of various medicinal plants on tracheal smooth muscle, their possible mechanism(s) and potency
Farzaneh Shakeri, Mohammad Hossein Boskabady
Journal of Ethnopharmacology.2015; 175: 528. CrossRef
Lead Screening for HIV-1 Integrase (IN) Inhibited by Traditional Chinese Medicine
Tzu-Chieh Hung, Wen-Yuan Lee, Kuen-Bao Chen, Yueh-Chiu Chan, Calvin Yu-Chian Chen
BioMed Research International.2014; 2014: 1. CrossRef
Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava
Fatih Karadeniz, Kyong-Hwa Kang, Jae W Park, Sun-Joo Park, Se-Kwon Kim
Bioscience, Biotechnology, and Biochemistry.2014; 78(7): 1151. CrossRef
Virological efficacy and immunological recovery among Ethiopian HIV-1 infected adults and children
Andargachew Mulu, Uwe Gerd Liebert, Melanie Maier
BMC Infectious Diseases.2014;[Epub] CrossRef
Potential Anti-HIV Agents from Marine Resources: An Overview
Thanh-Sang Vo, Se-Kwon Kim
Marine Drugs.2010; 8(12): 2871. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Anti-HIV-1 Efficacy of Extracts from Medicinal Plants

J. Microbiol. 2010;48(2):249-252. Published online May 1, 2010

DOI: https://doi.org/10.1007/s12275-009-0176-9

Related articles