Heterogeneous Virulence Potential and High Antibiotic Resistance of Pseudomonas aeruginosa Strains Isolated from Korean Pneumonia Patients

Mi Young Yoon; Kang-Mu Lee; Seok Hoon Jeong; Jungmin Kim; Sang Sun Yoon

doi:10.1007/s12275-010-9388-2

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Heterogeneous Virulence Potential and High Antibiotic Resistance of Pseudomonas aeruginosa Strains Isolated from Korean Pneumonia Patients: Mi Young Yoon ¹, Kang-Mu Lee ¹, Seok Hoon Jeong ^2,3, Jungmin Kim ⁴, Sang Sun Yoon ^1,3,5; Journal of Microbiology 2010;48(4):518-525.
DOI: https://doi.org/10.1007/s12275-010-9388-2
Published online: August 20, 2010

¹Department of Microbiology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ²Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ³Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ⁴Department of Microbiology, Kyungpook National University, School of Medicine, Daegu 700-422, Republic of Korea, ⁵Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea¹Department of Microbiology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ²Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ³Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea, ⁴Department of Microbiology, Kyungpook National University, School of Medicine, Daegu 700-422, Republic of Korea, ⁵Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea

Corresponding author: Sang Sun Yoon , Tel: +82-2-2228-1824,

Received: 18 December 2009 • Accepted: 29 April 2010

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Abstract

Pseudomonas aeruginosa is an opportunistic human pathogen of clinical importance that causes airway infections in immunocompromised patients. Here, we report the virulence-associated characteristics of strains of P. aeruginosa, isolated from the sputa of 25 Korean pneumonia patients. A high degree of genomic plasticity was observed by random amplified polymorphic DNA genotype analysis, suggesting that the infections were caused by strains with diverse genomic backgrounds. Biofilm formation of each isolate was heterogeneous in terms of their relative motilities. In addition, 48% of isolates were defective in the production of 3-oxo-C12-HSL (PAI-1), a quorum sensing signal molecule. In these strains, PAI-1-dependent elastase production was correspondingly decreased, suggesting that a large number of strains were presumed to be quorum sensing deficient. Multidrug resistance (MDR) was seen in 56% of the isolates tested, and 44% of the MDR strains were resistant to five or more antibiotics. Taken together, our results provide additional insights into the virulence traits of P. aeruginosa clinical isolates, which will aid in treating P. aeruginosa infections in pneumonia patients.

Keywords: P. aeruginosa;virulence;pneumonia;biofilm;quorum sensing

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Virulence Characteristics and an Action Mode of Antibiotic Resistance in Multidrug-Resistant Pseudomonas aeruginosa
Wontae Hwang, Sang Sun Yoon
Scientific Reports.2019;[Epub] CrossRef
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Keehoon Lee, Kang-Mu Lee, Junhyeok Go, Jae-Chan Ryu, Ji-Hwan Ryu, Sang Sun Yoon, Klaus Hantke
FEMS Microbiology Letters.2016; 363(11): fnw104. CrossRef
A single gene of a commensal microbe affects host susceptibility to enteric infection
Mi Young Yoon, Kyung Bae Min, Kang-Mu Lee, Yujin Yoon, Yaeseul Kim, Young Taek Oh, Keehoon Lee, Jongsik Chun, Byung-Yong Kim, Seok-Hwan Yoon, Insuk Lee, Chan Yeong Kim, Sang Sun Yoon
Nature Communications.2016;[Epub] CrossRef
Anaerobiosis-Induced Loss of Cytotoxicity Is Due to Inactivation of Quorum Sensing in Pseudomonas aeruginosa
Kang-Mu Lee, Mi Young Yoon, Yongjin Park, Joon-Hee Lee, Sang Sun Yoon, B. A. McCormick
Infection and Immunity.2011; 79(7): 2792. CrossRef

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Heterogeneous Virulence Potential and High Antibiotic Resistance of Pseudomonas aeruginosa Strains Isolated from Korean Pneumonia Patients

J. Microbiol. 2010;48(4):518-525. Published online August 20, 2010

DOI: https://doi.org/10.1007/s12275-010-9388-2

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