Glycosylation and Production Characteristics of Epothilones in Alkali-Tolerant Sorangium cellulosum Strain So0157-2

Lin Zhao; Peng-fei Li; Chun-hua Lu; Shu-guang Li; Yue-mao Shen; Yue-zhong Li

doi:10.1007/s12275-010-0048-3

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Research Support, Non-U.S. Gov't
Glycosylation and Production Characteristics of Epothilones in Alkali-Tolerant Sorangium cellulosum Strain So0157-2: Lin Zhao ¹, Peng-fei Li ¹, Chun-hua Lu ², Shu-guang Li ¹, Yue-mao Shen ², Yue-zhong Li ¹; Journal of Microbiology 2010;48(4):438-444
DOI: https://doi.org/10.1007/s12275-010-0048-3
Published online: August 20, 2010

¹State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan 250100, P. R. China, ²Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, Fujian Laboratory of Pharmaceutical Engineering, School of Life Science, Xiamen University, Xiamen, Fujian 361005, P. R. China¹State Key Laboratory of Microbial Technology, School of Life Science, Shandong University, Jinan 250100, P. R. China, ²Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, Fujian Laboratory of Pharmaceutical Engineering, School of Life Science, Xiamen University, Xiamen, Fujian 361005, P. R. China

Corresponding author: Yue-mao Shen , Tel: +86-531-8856-4288,
Yue-zhong Li , Tel: +86-531-8856-4288,

Received: 2 February 2010 • Accepted: 10 April 2010

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Abstract

3-O-α-D-ribofuranosyl epothilone A (epothiloneoside A) is a major component of glycosylated epothilones in Sorangium cellulosum strain So0157-2. The production and glycosylation ratios of epothiloneoside A in both solid and liquid culture conditions with various pH values and carbon sources were studied. The results showed that glycosylation occurs whenever epothilones are produced, regardless of changes in pH values, production time curves, and different carbon sources. We suggest that glycosylation is a stable process, paralleling the biosynthesis of epothilones in the So0157-2 strain.

Keywords: S. cellulosum; epothilones; glycosylation; epothiloneoside A

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Glycosylation and Production Characteristics of Epothilones in Alkali-Tolerant Sorangium cellulosum Strain So0157-2

J. Microbiol. 2010;48(4):438-444. Published online August 20, 2010

DOI: https://doi.org/10.1007/s12275-010-0048-3

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