Endophytic Fungus Trichothecium roseum LZ93 Antagonizing Pathogenic Fungi In Vitro and Its Secondary Metabolites

XiaoMei Zhang; GuoHong Li; Juan Ma; Ying Zeng; WeiGuang Ma; PeiJi Zhao

doi:10.1007/s12275-010-0173-z

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Endophytic Fungus Trichothecium roseum LZ93 Antagonizing Pathogenic Fungi In Vitro and Its Secondary Metabolites: XiaoMei Zhang ^1,2, GuoHong Li ³, Juan Ma ¹, Ying Zeng ¹, WeiGuang Ma ², PeiJi Zhao ¹; Journal of Microbiology 2010;48(6):784-790
DOI: https://doi.org/10.1007/s12275-010-0173-z
Published online: January 9, 2011

¹The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China, ²College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650200, P. R. China, ³Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, P. R. China¹The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China, ²College of Traditional Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming 650200, P. R. China, ³Laboratory for Conservation and Utilization of Bio-resource, Yunnan University, Kunming 650091, P. R. China

Corresponding author: PeiJi Zhao , Tel: +86-871-522-3111,

Received: 10 May 2010 • Accepted: 16 August 2010

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Abstract

The endophytic fungus Trichothecium roseum LZ93 from Maytenus hookeri was found to antagonize other pathogenic fungi in vitro. To identify which compound contributed substantially to the antagonism, we fermented the strain and purified its fermentation products. Eleven compounds were obtained, including two trichothecenes, five rosenonolactones, two cardiotonic cyclodepsipeptides, and two sterols. Compound 11β-hydroxyrosenonolactone (1) was assigned according to 1D and 2D-NMR data for the first time. At the same time, the 1H and 13C-NMR assignments for 6β-hydroxyrosenonolactone (2) were revised. Of all of them, only trichothecin (6) showed strong antifungal activity. Based on our observations of the antagonistic activity and the other experimental results, we suggest that the antifungal compound trichothecin was the main contributor to the antagonistic action of T. roseum LZ93.

Keywords: antifungal; antagonism; endophytes; pathogenic fungi; trichothecin

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Endophytic Fungus Trichothecium roseum LZ93 Antagonizing Pathogenic Fungi In Vitro and Its Secondary Metabolites

J. Microbiol. 2010;48(6):784-790. Published online January 9, 2011

DOI: https://doi.org/10.1007/s12275-010-0173-z

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