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Research Support, Non-U.S. Gov't
- NOTE] Kaposi’s Sarcoma-Associated Herpesvirus Infection of Endothelial Progenitor Cells Impairs Angiogenic Activity In Vitro
- Seungchul Yoo 1, Sil Kim 1, Seungmin Yoo 1, In-Taek Hwang 2, Haewol Cho 1, Myung-Shin Lee 1
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Journal of Microbiology 2011;49(2):299-304
DOI: https://doi.org/10.1007/s12275-011-0408-7
Published online: May 3, 2011
1Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 301-746, Republic of Korea, 2Department of Obstetrics and Gynecology, Eulji University School of Medicine, Daejeon 301-746, Republic of Korea1Department of Microbiology and Immunology, Eulji University School of Medicine, Daejeon 301-746, Republic of Korea, 2Department of Obstetrics and Gynecology, Eulji University School of Medicine, Daejeon 301-746, Republic of Korea
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Corresponding author:
Myung-Shin Lee , Tel: +82-42-259-1662,
Received: 6 October 2010 • Accepted: 29 November 2010
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Abstract
A recent study reported that endothelial progenitor cells (EPCs) are one of the reservoirs of Kaposi’s sarcoma associated herpesvirus (KSHV). Although EPCs are closely linked to angiogenesis and vasculogenesis, little is known about the angiogenic potential of KSHV in EPCs. In this study, we used EPCs isolated from human umbilical cord blood to show that early infection by KSHV in vitro impaired the neovascularization of EPCs in matrigel. Our results suggest that KSHV may disrupt the angiogenic potential of EPCs and that the disseminated infection of KSHV could be associated with EPC dysfunction.
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