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Research Support, U.S. Gov't, Non-P.H.S.
- NOTE] The Helicobacter pylori Ferric Uptake Regulator (Fur) Is Essential for Growth Under Sodium Chloride Stress
- Hanan Gancz , D. Scott Merrell
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Journal of Microbiology 2011;49(2):294-298.
DOI: https://doi.org/10.1007/s12275-011-0396-7
Published online: May 3, 2011
Department of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USADepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814, USA
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Corresponding author:
D. Scott Merrell , Tel: +1-301-295-1584,
Received: 29 September 2010 • Accepted: 22 November 2010
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Abstract
Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.
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