Abstract
Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.
Citations
Citations to this article as recorded by

-
High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in
Helicobacter pylori
Hongming Huang, Huang Yang, Shunhang Feng, Xiaoyan Zhang, Chu Chen, Hongyu Yan, Rui Li, Mengxin Liu, Juan Lin, Yancheng Wen, Feifei She, Anne-Catrin Uhlemann
Antimicrobial Agents and Chemotherapy.2024;[Epub] CrossRef -
A Positively Selected
fur
-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression
John T. Loh, Emily L. Struttmann, Natalie Favret, M. Lorena Harvey, Suman B. Pakala, Abha Chopra, Mark S. McClain, Timothy L. Cover, Denise Monack
Infection and Immunity.2023;[Epub] CrossRef - Metal binding and oligomerization properties of FurC (PerR) from Anabaena sp. PCC7120: an additional layer of regulation?
Cristina Sarasa-Buisan, Etienne Emonot, Marta Martínez-Júlvez, Emma Sevilla, Adrián Velázquez-Campoy, Serge Crouzy, M Teresa Bes, Isabelle Michaud-Soret, María F Fillat
Metallomics.2022;[Epub] CrossRef - Insights into the Orchestration of Gene Transcription Regulators in Helicobacter pylori
Andrea Vannini, Davide Roncarati, Federico D’Agostino, Federico Antoniciello, Vincenzo Scarlato
International Journal of Molecular Sciences.2022; 23(22): 13688. CrossRef - Interplay between Amoxicillin Resistance and Osmotic Stress in Helicobacter pylori
Ian H. Windham, D. Scott Merrell, George O’Toole
Journal of Bacteriology.2022;[Epub] CrossRef -
Transcriptional response to metal starvation in the emerging pathogen
Mycoplasma genitalium
is mediated by Fur-dependent and –independent regulatory pathways
Carlos Martínez-Torró, Sergi Torres-Puig, Marta Monge, Lucía Sánchez-Alba, Miguel González-Martín, Marina Marcos-Silva, Alex Perálvarez-Marín, Francesc Canals, Enrique Querol, Jaume Piñol, Oscar Q. Pich
Emerging Microbes & Infections.2020; 9(1): 5. CrossRef - High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins
John T. Loh, Amber C. Beckett, Matthew B. Scholz, Timothy L. Cover, Vincent B. Young
Infection and Immunity.2018;[Epub] CrossRef - Bismuth-Induced Inactivation of Ferric Uptake Regulator from Helicobacter pylori
Xiaojun He, Xiangwen Liao, Hongyan Li, Wei Xia, Hongzhe Sun
Inorganic Chemistry.2017; 56(24): 15041. CrossRef - Characterization of Key Helicobacter pylori Regulators Identifies a Role for ArsRS in Biofilm Formation
Stephanie L. Servetas, Beth M. Carpenter, Kathryn P. Haley, Jeremy J. Gilbreath, Jennifer A. Gaddy, D. Scott Merrell, T. J. Silhavy
Journal of Bacteriology.2016; 198(18): 2536. CrossRef - Characterization of the mechanism of prolonged adaptation to osmotic stress of Jeotgalibacillus malaysiensis via genome and transcriptome sequencing analyses
Amira Suriaty Yaakop, Kok-Gan Chan, Robson Ee, Yan Lue Lim, Siew-Kim Lee, Fazilah Abd Manan, Kian Mau Goh
Scientific Reports.2016;[Epub] CrossRef -
Helicobacter pylori Adaptation
In Vivo
in Response to a High-Salt Diet
John T. Loh, Jennifer A. Gaddy, Holly M. Scott Algood, Silvana Gaudieri, Simon Mallal, Timothy L. Cover, S. R. Blanke
Infection and Immunity.2015; 83(12): 4871. CrossRef - Global Microarray Analysis of Alkaliphilic Halotolerant Bacterium Bacillus sp. N16-5 Salt Stress Adaptation
Liang Yin, Yanfen Xue, Yanhe Ma, Marie-Joelle Virolle
PLOS ONE.2015; 10(6): e0128649. CrossRef - Metabolic Shift of Escherichia coli under Salt Stress in the Presence of Glycine Betaine
A. Metris, S. M. George, F. Mulholland, A. T. Carter, J. Baranyi, J. Björkroth
Applied and Environmental Microbiology.2014; 80(15): 4745. CrossRef - Proteomic Analysis of a NAP1 Clostridium difficile Clinical Isolate Resistant to Metronidazole
Patrick M. Chong, Tarah Lynch, Stuart McCorrister, Pamela Kibsey, Mark Miller, Denise Gravel, Garrett R. Westmacott, Michael R. Mulvey, Axel Cloeckaert
PLoS ONE.2014; 9(1): e82622. CrossRef - Characterization of NaCl tolerance in Desulfovibrio vulgaris Hildenborough through experimental evolution
Aifen Zhou, Edward Baidoo, Zhili He, Aindrila Mukhopadhyay, Jason K Baumohl, Peter Benke, Marcin P Joachimiak, Ming Xie, Rong Song, Adam P Arkin, Terry C Hazen, Jay D Keasling, Judy D Wall, David A Stahl, Jizhong Zhou
The ISME Journal.2013; 7(9): 1790. CrossRef - Crosstalk between Helicobacter pylori and Gastric Epithelial Cells Is Impaired by Docosahexaenoic Acid
Marta Correia, Valérie Michel, Hugo Osório, Meriem El Ghachi, Mathilde Bonis, Ivo G. Boneca, Hilde De Reuse, António A. Matos, Pascal Lenormand, Raquel Seruca, Ceu Figueiredo, Jose Carlos Machado, Eliette Touati, Georgina L. Hold
PLoS ONE.2013; 8(4): e60657. CrossRef -
The Ferric Uptake Regulator of
Helicobacter Pylori
: a Critical Player in the Battle for Iron and Colonization of the Stomach
Oscar Q Pich, D Scott Merrell
Future Microbiology.2013; 8(6): 725. CrossRef - Detailed analysis of Helicobacter pylori Fur‐regulated promoters reveals a Fur box core sequence and novel Fur‐regulated genes
Oscar Q. Pich, Beth M. Carpenter, Jeremy J. Gilbreath, D. Scott Merrell
Molecular Microbiology.2012; 84(5): 921. CrossRef -
Analysis of
Helicobacter pylori cagA
Promoter Elements Required for Salt-Induced Upregulation of CagA Expression
John T. Loh, David B. Friedman, M. Blanca Piazuelo, Luis E. Bravo, Keith T. Wilson, Richard M. Peek, Pelayo Correa, Timothy L. Cover, S. R. Blanke
Infection and Immunity.2012; 80(9): 3094. CrossRef