Protein-Protein Interactions between Histidine Kinases and Response Regulators of Mycobacterium tuberculosis H37Rv

Ha-Na Lee; Kwang-Eun Jung; In-Jeong Ko; Hyung Suk Baik; Jeong-Il Oh

doi:10.1007/s12275-012-2050-4

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Research Support, Non-U.S. Gov't
Protein-Protein Interactions between Histidine Kinases and Response Regulators of Mycobacterium tuberculosis H37Rv: Ha-Na Lee ¹, Kwang-Eun Jung ¹, In-Jeong Ko ², Hyung Suk Baik ¹, Jeong-Il Oh ¹; Journal of Microbiology 2012;50(2):270-277.
DOI: https://doi.org/10.1007/s12275-012-2050-4
Published online: April 27, 2012

¹Department of Microbiology, Pusan National University, Busan 609-735, Republic of Korea, ²Korea Science Academy of KAIST, Busan 614-822, Republic of Korea¹Department of Microbiology, Pusan National University, Busan 609-735, Republic of Korea, ²Korea Science Academy of KAIST, Busan 614-822, Republic of Korea

Corresponding author: Jeong-Il Oh , Tel: +82-51-510-2593,

Received: 31 January 2012 • Accepted: 3 February 2012

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Abstract

Using yeast two-hybrid assay, we investigated protein-protein interactions between all orthologous histidine kinase (HK)/response regulator (RR) pairs of M. tuberculosis H37Rv and identified potential protein-protein interactions between a noncognate HK/RR pair, DosT/NarL. The protein interaction between DosT and NarL was verified by phosphotransfer reaction from DosT to NarL. Furthermore, we found that the DosT and DosS HKs, which share considerable sequence similarities to each other and form a twocomponent system with the DosR RR, have different crossinteraction capabilities with NarL: DosT interacted with NarL, while DosS did not. The dimerization domains of DosT and DosS were shown to be sufficient to confer specificity for DosR, and the different cross-interaction abilities of DosS and DosT with NarL were demonstrated to be attributable to variations in the amino acid sequences of the α2-helices of their dimerization domains.

Keywords: histidine kinase;Mycobacterium tuberculosis;protein interaction;response regulator;two-component system

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Protein-Protein Interactions between Histidine Kinases and Response Regulators of Mycobacterium tuberculosis H37Rv

J. Microbiol. 2012;50(2):270-277. Published online April 27, 2012

DOI: https://doi.org/10.1007/s12275-012-2050-4

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