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Research Support, Non-U.S. Gov't
- NOTE] Envelope Diversity, Characteristics of V3 Region and Predicted Co-Receptor Usage of Human Immunodeficiency Viruses Infecting North Indians
- Raiees Andrabi 1, Rajesh Kumar 1, Manju Bala 2, Ambili Nair 1, Prakash SS 1, Vandana Kushwaha 1, Kalpana Luthra 1
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Journal of Microbiology 2012;50(5):869-873
DOI: https://doi.org/10.1007/s12275-012-2136-z
Published online: November 4, 2012
1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, 2Regional STD Teaching Training & Research Centre, Safdarjung Hospital, New Delhi, India1Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India, 2Regional STD Teaching Training & Research Centre, Safdarjung Hospital, New Delhi, India
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Corresponding author:
Kalpana Luthra , Tel: +91-11-26546431,
Received: 12 March 2012 • Accepted: 12 June 2012
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Abstract
Subtypes of human immunodeficiency virus type 1 circulating in 21 north Indian patients were characterized based on the partial sequence of the gp120 envelope protein. A majority of viruses (85.7%, 18/21) were subtype C, while 14.3% (3/21) were subtype A. Sequence analysis revealed that the V3 region was highly conserved compared with V4 and V5. The predicted use of co-receptors indicated exclusive usage of R5, except for two subtype A viruses (AIIMS279 and AIIMS281). Our results demonstrate conservation within the V3 loop of subtype C viruses, and suggest the emergence of non-clade C viruses in the north Indian population.
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