NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011

Sehee Park; Jin Il Kim; Ilseob Lee; Sangmoo Lee; Min-Woong Hwang; Joon-Yong Bae; Jun Heo; Eun-Joo Lim; Won-Seok Seok; Hee Jin Cheong; Joon Young Song; Woo Joo Kim; Man-Seong Park

doi:10.1007/s12275-012-2541-3

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Research Support, Non-U.S. Gov't
NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011: Sehee Park ^1,2, Jin Il Kim ^1,2, Ilseob Lee ^1,2, Sangmoo Lee ^1,2, Min-Woong Hwang ^1,2, Joon-Yong Bae ^1,2, Jun Heo ^1,2, Eun-Joo Lim ³, Won-Seok Seok ³, Hee Jin Cheong ⁴, Joon Young Song ⁴, Woo Joo Kim ⁴, Man-Seong Park ^1,2; Journal of Microbiology 2012;50(6):1067-1070
DOI: https://doi.org/10.1007/s12275-012-2541-3
Published online: December 30, 2012

¹Department of Microbiology, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³Infectious Disease Investigation Division, Gangwon Institute of Health and Environment, Chuncheon 200-820, Republic of Korea, ⁴Division of Infectious Diseases, Korea University Guro Hospital, College of Medicine, Korea University, Seoul 152-703, Republic of Korea¹Department of Microbiology, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ²Center for Medical Science Research, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea, ³Infectious Disease Investigation Division, Gangwon Institute of Health and Environment, Chuncheon 200-820, Republic of Korea, ⁴Division of Infectious Diseases, Korea University Guro Hospital, College of Medicine, Korea University, Seoul 152-703, Republic of Korea

Corresponding author: Man-Seong Park , Tel: +82-33-248-2632,

Received: 5 October 2012 • Accepted: 31 October 2012

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Abstract

During the 2009–2011 influenza seasons, 10.26% of the specimens isolated from patients in South Korea were subtyped as H3N2 viruses. Some oseltamivir-sensitive H3N2 samples exhibited different plaque morphologies, and were found to have novel mutations in the neuraminidase gene. In a subsequent analysis using NA mutant viruses, viral compensation against oseltamivir treatment was observed only in the N2 mutant virus. All things considered, these novel mutations may account for the exclusive characteristics of selected H3N2 viruses observed in plaque reduction assays.

Keywords: influenza; neuraminidase; oseltamivir

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NOTE] Susceptibility of Human H3N2 Influenza Virus to Oseltamivir in South Korea, 2009–2011

J. Microbiol. 2012;50(6):1067-1070. Published online December 30, 2012

DOI: https://doi.org/10.1007/s12275-012-2541-3

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