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Research Support, Non-U.S. Gov't
- NOTE] Comparative Assessment of the Intracellular Survival of the Burkholderia pseudomallei bopC Mutant
- Varintip Srinon 1, Sunsiree Muangman 1, Nithima Imyaem 1, Veerachat Muangsombut 1, Natalie R. Lazar Adler 2, Edouard E. Galyov 2, Sunee Korbsrisate 1
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Journal of Microbiology 2013;51(4):522-526.
DOI: https://doi.org/10.1007/s12275-013-2557-3
Published online: August 30, 2013
1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, 2Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom1Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand, 2Department of Infection, Immunity and Inflammation, University of Leicester, Leicester LE1 9HN, United Kingdom
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Corresponding author:
Sunee Korbsrisate , Tel: +662-419-6636,
Received: 15 October 2012 • Accepted: 16 March 2013
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Abstract
Burkholderia pseudomallei, the causative agent of melioidosis, is a Gram-negative saprophytic bacterium capable of surviving within phagocytic cells. To assess the role of BopC (a type III secreted effector protein) in the pathogenesis of B. pseudomallei, a B. pseudomallei bopC mutant was used to infect J774A.1 macrophage-like cells. The bopC mutant showed significantly reduced intracellular survival in infected macrophages compared to wild-type B. pseudomallei. In addition, the bopC mutant displayed delayed escape from endocytic vesicles compared with the wild-type strain. This indicates that BopC is important, and at least in part, needed for intracellular survival of B. pseudomallei.
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