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HOME > J. Microbiol > Volume 51(6); 2013 > Article
Research Support, Non-U.S. Gov't
A Putative APSES Transcription Factor Is Necessary for Normal Growth and Development of Aspergillus nidulans
Ji-Yeon Lee 1, Lee-Han Kim 1, Ha-Eun Kim 1, Jae-Sin Park 1, Kap-Hoon Han 2, Dong-Min Han 1
Journal of Microbiology 2013;51(6):800-806.
DOI: https://doi.org/10.1007/s12275-013-3100-2
Published online: December 19, 2013
1Division of Life Science, Wonkwang University, Iksan 570-749, Republic of Korea, 2Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-901, Republic of Korea1Division of Life Science, Wonkwang University, Iksan 570-749, Republic of Korea, 2Department of Pharmaceutical Engineering, Woosuk University, Wanju 565-901, Republic of Korea
Corresponding author:  Dong-Min Han , Tel: +82-63-850-6220, 
Received: 15 February 2013   • Accepted: 11 June 2013
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Abstract

The nsdD gene encoding a GATA type transcription factor positively controls sexual development in Aspergillus nidulans. According to microarray data, 20 genes that were upregulated by deleting nsdD during various life cycle stages were randomly selected and deleted for functional analysis. None of the mutants showed apparent changes in growth or development compared with those of the wild-type except the AN3154 gene that encodes a putative APSES transcription factor and is an ortholog of Saccharomyces cerevisiae swi4. Deleting AN3154 resulted in retarded growth and development, and the gene was named rgdA (retared growth and development). The rgdA deletion mutant developed a reduced number of conidia even under favorable conditions for asexual development. The retarded growth and development was partially suppressed by the veA1 mutation. The conidial heads of the mutant aborted, showing reduced and irregular shaped phialides. Fruiting body development was delayed compared with that in the wild-type. The mutant did not respond to various nutritional or environmental factors that affected the development patterns. The rgdA gene was expressed at low levels throughout the life cycle and was not significantly affected by several regulators of sexual and asexual development such as nsdD, veA, stuA, or brlA. However, the rgdA gene affected brlA and abaA expression, which function as key regulators of asexual sporulation, suggesting that rgdA functions upstream of those genes.

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    A Putative APSES Transcription Factor Is Necessary for Normal Growth and Development of Aspergillus nidulans
    J. Microbiol. 2013;51(6):800-806.   Published online December 19, 2013
    DOI: https://doi.org/10.1007/s12275-013-3100-2
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