Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults

Hao Zhang; Jing Sun; Xianting Liu; Chuan Hong; Yuanbo Zhu; Aiping Liu; Siqi Li; Huiyuan Guo; Fazheng Ren

doi:10.1007/s12275-013-3279-2

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Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults: Hao Zhang ^1,2, Jing Sun ¹, Xianting Liu ¹, Chuan Hong ¹, Yuanbo Zhu ¹, Aiping Liu ³, Siqi Li ¹, Huiyuan Guo ¹, Fazheng Ren ^1,2; Journal of Microbiology 2013;51(6):777-782.
DOI: https://doi.org/10.1007/s12275-013-3279-2
Published online: December 19, 2013

¹Beijing Laboratory for Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China, ²Beijing Higher Institution Engineering Research Center of Animal Product, Beijing, P. R. China, ³Diary Department, MengNiu Diary Company, Beijing, P. R. China¹Beijing Laboratory for Food Quality and Safety, and Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, P. R. China, ²Beijing Higher Institution Engineering Research Center of Animal Product, Beijing, P. R. China, ³Diary Department, MengNiu Diary Company, Beijing, P. R. China

Corresponding author: Fazheng Ren , Tel: .,

Received: 13 May 2013 • Accepted: 21 August 2013

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Abstract

Lactobacillus paracasei subsp. paracasei LC01 (LC01) can tolerate intestinal stresses and has antioxidant activity. To evaluate the effect of the bacterium on human intestinal microflora, a randomized, double-blind, placebo-controlled human trial was carried out. Fifty-two healthy adult volunteers were randomized equally to two groups. One group consumed 12% (wt/vol) skimmed milk supplemented with 1010 CFU of LC01 each day for the 4-week treatment period, and then consumed placebo in the next treatment period, separated by a 2-week washout. The other group followed the reverse order. Group-specific real-time PCR and biochemical analyses was used to determine the intestinal bacterial composition of fecal samples collected at the end of every period, and the concentration of short-chain fatty acids and ammonia. A significant inhibition in fecal Escherichia coli and increase in Lactobacillus, Bifidobacterium, and Roseburia intestinalis were observed after consumption of LC01. Acetic acid and butyric acid were significantly higher in the probiotic stage and fecal ammonia was significantly lower. The results indicated a modulation effect of LC01 on the intestinal microflora of young adults, suggesting a beneficial effect on bowel health. LC01 may have potential value as a probiotic.

Keywords: human trial;Lactobacillus paracasei subsp. paracasei LC01;intestinal microflora;short-chain fatty acid;ammonia

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Lactobacillus paracasei subsp. paracasei LC01 Positively Modulates Intestinal Microflora in Healthy Young Adults

J. Microbiol. 2013;51(6):777-782. Published online December 19, 2013

DOI: https://doi.org/10.1007/s12275-013-3279-2

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