Plasminogen Activator Inhibitor Type 1 Expression Induced by Lipopolysaccharide of Porphyromonas gingivalis in Human Gingival Fibroblast

Hee Sam Na; Eun J. Lim; So Y. Jeong; Mi H. Ryu; Mi Hee Park; Jin Chung

doi:10.1007/s12275-014-3022-7

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Plasminogen Activator Inhibitor Type 1 Expression Induced by Lipopolysaccharide of Porphyromonas gingivalis in Human Gingival Fibroblast: Hee Sam Na ¹, Eun J. Lim ¹, So Y. Jeong ¹, Mi H. Ryu ², Mi Hee Park ¹, Jin Chung ¹; Journal of Microbiology 2014;52(2):154-160.
DOI: https://doi.org/10.1007/s12275-014-3022-7
Published online: February 1, 2014

¹Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 626-810, Republic of Korea, ²Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan 626-810, Republic of Korea¹Department of Oral Microbiology, School of Dentistry, Pusan National University, Yangsan 626-810, Republic of Korea, ²Department of Oral Pathology, School of Dentistry, Pusan National University, Yangsan 626-810, Republic of Korea

Corresponding author: Jin Chung , Tel: Tel.: +82-51-510-8247,

Received: 9 June 2013 • Revised: 6 August 2013 • Accepted: 23 August 2013

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Abstract

In the gingival tissues of patients with periodontitis, inflammatory responses are mediated by a wide variety of genes. In our previous screening study, plasminogen activator inhibitor type 1 (PAI-1) mRNA binding protein expression was increased in gingiva from periodontitis patients. In this study, we further investigated the signaling pathway involved in PAI-1 expression induced by Porphyromonas gingivalis LPS (Pg LPS) in human gingival fibroblasts (HGF). When HGFs were treated with Pg LPS, both PAI-1 mRNA expression and PAI-1 protein were induced in a dose-dependent manner. Pg LPS induced NF-κB activation and the expressions of PAI-1 mRNA and protein were suppressed by pretreating with a NF-κB inhibitor. Pg LPS also induced ERK, p38, and JNK activation, and Pg LPS-induced PAI-1 expression was inhibited by ERK/p38/JNK inhibitor pretreatment. In conclusion, Pg LPS induced PAI-1 expression through NF-κB and MAP kinases activation in HGF.

Keywords: Porphyromonas gingivalis;PAI-1;periodontitis

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Plasminogen Activator Inhibitor Type 1 Expression Induced by Lipopolysaccharide of Porphyromonas gingivalis in Human Gingival Fibroblast

J. Microbiol. 2014;52(2):154-160. Published online February 1, 2014

DOI: https://doi.org/10.1007/s12275-014-3022-7

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