NOTE] Identification of Secreted Virulence Factors of Chromobacterium violaceum

Thiago Castro-Gomes; Mariana S. Cardoso; Wanderson D. DaRocha; Letícia A. Laibida; Andréa M. A. Nascimento; Luciana W. Zuccherato; Maria Fátima Horta; Marcelo P. Bemquerer; Santuza M. R. Teixeira

doi:10.1007/s12275-014-3202-5

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Research Support, Non-U.S. Gov't
NOTE] Identification of Secreted Virulence Factors of Chromobacterium violaceum: Thiago Castro-Gomes ¹, Mariana S. Cardoso ¹, Wanderson D. DaRocha ², Letícia A. Laibida ², Andréa M. A. Nascimento ³, Luciana W. Zuccherato ³, Maria Fátima Horta ¹, Marcelo P. Bemquerer ⁴, Santuza M. R. Teixeira ¹; Journal of Microbiology 2014;52(4):350-353
DOI: https://doi.org/10.1007/s12275-014-3202-5
Published online: February 17, 2014

¹Departamento de Bioquímica e Imunologia and Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, ²Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil , ³Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, ⁴EMBRAPA Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil¹Departamento de Bioquímica e Imunologia and Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, ²Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, Curitiba, PR, Brazil , ³Departamento de Biologia Geral, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil, ⁴EMBRAPA Recursos Genéticos e Biotecnologia, Brasília, DF, Brazil

Corresponding author: Santuza M. R. Teixeira , Tel: +55-31-3409-2665,

Received: 5 April 2013 • Revised: 1 August 2013 • Accepted: 8 August 2013

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Abstract

Chromobacterium violaceum, a component of tropical soil microbiota, is an opportunistic pathogenic bacterium that can infect humans and other animals. In addition to identifying a large number of genes that demonstrate the vast biotechnological potential of this bacterium, genome sequencing revealed several virulence factors, including different cytolysins, which can be related to its pathogenicity. Here we confirmed these predictions from genomic analyses by identifying, through mass spectrometry, proteins present in the culture supernatant of C. violaceum that may constitute secreted virulence factors. Among them, we identified a secreted collagenase and the product of a gene with sequence similarity to previously characterized bacterial porins.

Keywords: Chromobacterium violaceum; genome; hemolysin; virulence factor

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NOTE] Identification of Secreted Virulence Factors of Chromobacterium violaceum

J. Microbiol. 2014;52(4):350-353. Published online February 17, 2014

DOI: https://doi.org/10.1007/s12275-014-3202-5

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