Abstract
The K418 chimeric virus of porcine reproductive and respiratory syndrome virus (PRRSV) was engineered by replacing the genomic region containing structure protein genes of an infectious clone of PRRSV, FL12, with the same region obtained
from a Korean dominant field strain, LMY. The K418 reached 106 TCID50/ml of viral titer with similar growth kinetics to those of parental strains and had a cross-reactive
neutralizing antibody response to field serum from the entire country. The chimeric clone pK418 can be used as a practical tool for further studying the molecular characteristics of PRRSV proteins through genetic manipulation. Furthermore,
successful construction of the K418 will allow for the development of customized vaccine candidates against PRRSV, which has evolved rapidly in Korea.
Citations
Citations to this article as recorded by
- Monitoring reported SARS-CoV-2 variants to assess the status of COVID-19 epidemics in the low epidemic state
Bin Liu, Zhongliang Wang, Shanshan Lu, Zhongtian Qi, Zhijie Zhang, Jie Luan, Jianbo Ba
Scientific Reports.2025;[Epub] CrossRef -
Bibliometrics and
meta
-analysis of self-healing bio-concrete – a systematic review
Shahid Ul Islam, Shakeel Ahmad Waseem
European Journal of Environmental and Civil Engineering.2025; 29(5): 933. CrossRef - Utilization of bacteria and treated wastewater for the production of sustainable building materials
Tanya Pachori, Bhavdeep Sharma, Shruti Sharma, M. Sudhakara Reddy
Journal of Environmental Chemical Engineering.2025; 13(5): 118449. CrossRef - Porcine Reproductive and Respiratory Syndrome Virus Engineered by Serine Substitution on the 44th Amino Acid of GP5 Resulted in a Potential Vaccine Candidate with the Ability to Produce High Levels of Neutralizing Antibody
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Veterinary Sciences.2023; 10(3): 191. CrossRef - Porcine Reproductive and Respiratory Syndrome Virus: Immune Escape and Application of Reverse Genetics in Attenuated Live Vaccine Development
Honglei Wang, Yangyang Xu, Wenhai Feng
Vaccines.2021; 9(5): 480. CrossRef - Evaluation of the Cross-Protective Efficacy of a Chimeric PRRSV Vaccine against Two Genetically Diverse PRRSV2 Field Strains in a Reproductive Model
Chang-Gi Jeong, Amina Khatun, Salik Nazki, Seung-Chai Kim, Yun-Hee Noh, Sang-Chul Kang, Dong-Uk Lee, Myeon-Sik Yang, Nadeem Shabir, In-Joong Yoon, Bumseok Kim, Won-Il Kim
Vaccines.2021; 9(11): 1258. CrossRef - Comparative Evaluation of Antibacterial Activity of Probiotics SK12 and SM18: An In Vitro Study
Shanthala B Mallikarjun, Srihari Nirguna Chandrasekhar, Henna P Salim
International Journal of Clinical Pediatric Dentistry.2021; 13(6): 611. CrossRef - A chimeric porcine reproductive and respiratory syndrome virus (PRRSV)-2 vaccine is safe under international guidelines and effective both in experimental and field conditions
Hwi-Yeon Choi, So-Hyun Lee, So-Hyeun Ahn, Jong-Chul Choi, Ji-Yun Jeong, Beom-Joo Lee, Yeong-Lim Kang, Seong-Soo Hwang, Jung-Keun Lee, Sang-Won Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Joong-Bok Lee
Research in Veterinary Science.2021; 135: 143. CrossRef - Effect of encapsulated bacteria on concrete properties: A review
Irfan Yaqoob Wani, Khushpreet Singh
Materials Today: Proceedings.2020; 33: 1706. CrossRef - In vitro and in vivo studies of deglycosylated chimeric porcine reproductive and respiratory syndrome virus as a vaccine candidate and its realistic revenue impact at commercial pig production level
Jung-ju Kim, Jung-Ah Lee, Hwi-yeon Choi, Jang-hyuck Han, Won Huh, Jae-Ho Pi, Jung-Keun Lee, Sangshin Park, Ki-hyun Cho, Joong-bok Lee
Vaccine.2017; 35(37): 4966. CrossRef - Evaluation of the Cross-Protective Efficacy of a Chimeric Porcine Reproductive and Respiratory Syndrome Virus Constructed Based on Two Field Strains
Nadeem Shabir, Amina Khatun, Salik Nazki, Bumseok Kim, Eun-Jin Choi, Dong Sun, Kyoung-Jin Yoon, Won-Il Kim
Viruses.2016; 8(8): 240. CrossRef - Augmented immune responses in pigs immunized with an inactivated porcine reproductive and respiratory syndrome virus containing the deglycosylated glycoprotein 5 under field conditions
Jung-Ah Lee, Nak-Hyung Lee, Joong-Bok Lee, Seung-Yong Park, Chang-Seon Song, In-Soo Choi, Sang-Won Lee
Clinical and Experimental Vaccine Research.2016; 5(1): 70. CrossRef - Influence of biomineralization on a profile of a tropical soil affected by erosive processes
Yamile Valencia González, José Carvalho-Camapum, Luis Augusto Lara-Valencia
DYNA.2015; 82(192): 221. CrossRef - Comparison of the Ability of Two Bacteria to Improve the Behavior of Sandy Soil
Paulo J. Venda Oliveira, Milton S. da Costa, João N. P. Costa, M. Fernanda Nobre
Journal of Materials in Civil Engineering.2015;[Epub] CrossRef - Live porcine reproductive and respiratory syndrome virus vaccines: Current status and future direction
Gourapura J. Renukaradhya, Xiang-Jin Meng, Jay G. Calvert, Michael Roof, Kelly M. Lager
Vaccine.2015; 33(33): 4069. CrossRef - Influence of biomineralization on the physico-mechanical profile of a tropical soil affected by erosive processes
Y. Valencia, J. Camapum, F. Araripe Torres
Soil Biology and Biochemistry.2014; 74: 98. CrossRef - Influences on the carbonate hydrochemistry of mound spring environments, Lake Eyre South region, South Australia
Mark N. Keppel, Vincent E.A. Post, Andrew J. Love, Jonathan D.A. Clarke, Adrian D. Werner
Chemical Geology.2012; 296-297: 50. CrossRef - Mound springs in the arid Lake Eyre South region of South Australia: A new depositional tufa model and its controls
Mark N. Keppel, Jonathan D.A. Clarke, Todd Halihan, Andrew J. Love, Adrian D. Werner
Sedimentary Geology.2011; 240(3-4): 55. CrossRef - Effect of ureolytic bacteria on concrete properties
Rafat Siddique, Navneet Kaur Chahal
Construction and Building Materials.2011; 25(10): 3791. CrossRef
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