Abstract
			
			The Gram-negative pathogen Helicobacter pylori is increasingly more resistant to the three major antibiotics (metronidazole, clarithromycin and amoxicillin) that are most commonly used to treat infection. As a result, there is an increased rate of treatment failure; this translates into an overall higher cost of treatment due to the need for increased length of treatment and/or the requirement for combination or sequential
therapy. Given the rise in antibiotic resistance, the complicated treatment regime, and issues related to patient compliance that stem from the duration and complexity of treatment, there is clearly a pressing need for the development of novel therapeutic strategies to combat H. pylori infection. As such, researchers are actively investigating the utility of antimicrobial peptides, small molecule inhibitors and naturopathic therapies. Herein we review and discuss each of these novel approaches as a means to target this important gastric pathogen.			
						
						
					 
		
		
		 
		
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- Pistacia vera L. as natural source against antimicrobial and antiviral resistance
 Giuseppina Mandalari, Rosamaria Pennisi, Teresa Gervasi, Maria Teresa Sciortino
 Frontiers in Microbiology.2024;[Epub]     CrossRef
- Efficacy of a standardised herbal formulation in Helicobacter pylori positive patients with gastritis or peptic ulcer: a triple-blind randomised clinical trial
 Arefe Shojaeian, Alireza Khalilian, Maryam Mehrpoya, Jalal Poorolajal, Dara Dastan
 Journal of Herbal Medicine.2023; 41: 100706.     CrossRef
- Antibacterial, Antibiofilm, and Antioxidant Activity of 15 Different Plant-Based Natural Compounds in Comparison with Ciprofloxacin and Gentamicin
 Ali Pormohammad, Dave Hansen, Raymond J. Turner
 Antibiotics.2022; 11(8): 1099.     CrossRef
- Targeting the Essential Transcription Factor HP1043 of Helicobacter pylori: A Drug Repositioning Study
 Federico Antoniciello, Davide Roncarati, Annamaria Zannoni, Elena Chiti, Vincenzo Scarlato, Federica Chiappori
 Frontiers in Molecular Biosciences.2022;[Epub]     CrossRef
- 
          Helicobacter pylori eradication: Exploring its impacts on the gastric mucosa
 Chun-Yan Weng, Jing-Li Xu, Shao-Peng Sun, Kai-Jie Wang, Bin Lv
 World Journal of Gastroenterology.2021; 27(31): 5152.     CrossRef
- A Comprehensive Study on the Antimicrobial Properties of Resveratrol as an Alternative Therapy
 Ehsan Abedini, Ehsaneh Khodadadi, Elham Zeinalzadeh, Seyyed Reza Moaddab, Mohammad Asgharzadeh, Bahareh Mehramouz, Sounkalo Dao, Hossein Samadi Kafil, Weicheng Hu
 Evidence-Based Complementary and Alternative Medicine.2021; 2021: 1.     CrossRef
- Orally administrated chitosan microspheres bind Helicobacter pylori and decrease gastric infection in mice
 Patrícia C. Henriques, Lia M. Costa, Catarina L. Seabra, Bernardo Antunes, Ricardo Silva-Carvalho, Susana Junqueira-Neto, André F. Maia, Pedro Oliveira, Ana Magalhães, Celso A. Reis, Fátima Gartner, Eliette Touati, Joana Gomes, Paulo Costa, M. Cristina L.
 Acta Biomaterialia.2020; 114: 206.     CrossRef
- Effects of cinnamon extract on complications of treatment and eradication of Helicobacter pylori in infected people
 Ghazal Imani, Alireza khalilian, Dara Dastan, Behzad Imani, Maryam Mehrpoya
 Journal of Herbmed Pharmacology.2020; 9(1): 55.     CrossRef
- Flacourtia indica based biogenic nanoparticles: development, characterization, and bioactivity against wound associated pathogens
 Farooq Ahmad, Muhammad Babar Taj, Muhammad Ramzan, Ahmad Raheel, Saima Shabbir, Muhammad Imran, Hafiz M N Iqbal
 Materials Research Express.2020; 7(1): 015026.     CrossRef
- In vitro activity of neem (Azadirachta indica) oil extract against Helicobacter pylori
 Faith C. Blum, Jatinder Singh, D. Scott Merrell
 Journal of Ethnopharmacology.2019; 232: 236.     CrossRef
- Study of inhibitory effects of the mixture of cinnamon and ginger extracts on cagA gene expression of Helicobacter pylori by Real-Time RT-PCR technique
 Morteza Azadi, Asa Ebrahimi, Azad Khaledi, Davoud Esmaeili
 Gene Reports.2019; 17: 100493.     CrossRef
- In Vitro Activity of Diphenyleneiodonium toward Multidrug-Resistant Helicobacter pylori Strains
 Jun-Won Chung, Su Young Kim, Hee Jung Park, Chang Su Chung, Hee Woo Lee, Sun Mi Lee, Inki Kim, Jhang Ho Pak, Gin Hyug Lee, Jin-Yong Jeong
 Gut and Liver.2017; 11(5): 648.     CrossRef
- Helicobacter pylori treatment: New perspectives using current experience
 Amin Talebi Bezmin Abadi
 Journal of Global Antimicrobial Resistance.2017; 8: 123.     CrossRef
- 
            Selective killing of
            Helicobacter pylori
            with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides
          
 Menghua Xiong, Yan Bao, Xin Xu, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek, Lichen Yin, Lin-Feng Chen, Jianjun Cheng
 Proceedings of the National Academy of Sciences.2017; 114(48): 12675.     CrossRef
- Helicobacter pylori outer membrane protein, HomC, shows geographic dependent polymorphism that is influenced by the Bab family
 Aeryun Kim, Stephanie L. Servetas, Jieun Kang, Jinmoon Kim, Sungil Jang, Yun Hui Choi, Hanfu Su, Yeong-Eui Jeon, Youngmin A. Hong, Yun-Jung Yoo, D. Scott Merrell, Jeong-Heon Cha
 Journal of Microbiology.2016; 54(12): 846.     CrossRef
- Capsule Design for Blue Light Therapy against Helicobacter pylori
 Zhangyong Li, Binbin Ren, Haiyan Tan, Shengrong Liu, Wei Wang, Yu Pang, Jinzhao Lin, Chen Zeng, Dipshikha Chakravortty
 PLOS ONE.2016; 11(1): e0147531.     CrossRef
- Morphological changes in human gastric epithelial cells induced by nuclear targeting of Helicobacter pylori urease subunit A
 Jung Hwa Lee, So Hyun Jun, Jung-Min Kim, Seung Chul Baik, Je Chul Lee
 Journal of Microbiology.2015; 53(6): 406.     CrossRef
- Dietary amelioration of Helicobacter infection
 Jed W. Fahey, Katherine K. Stephenson, Alison J. Wallace
 Nutrition Research.2015; 35(6): 461.     CrossRef
- Antibiotic treatment forHelicobacter pylori: Is the end coming?
 Su Young Kim
 World Journal of Gastrointestinal Pharmacology and Therapeutics.2015; 6(4): 183.     CrossRef
- The potential utility of chitosan micro/nanoparticles in the treatment of gastric infection
 Inês C Gonçalves, Patrícia C Henriques, Catarina L Seabra, M Cristina L Martins
 Expert Review of Anti-infective Therapy.2014; 12(8): 981.     CrossRef