Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus

Mohammed Kawser Hossain; Hye Yeon Choi; Jae-Seon Hwang; Ahmed Abdal Dayem; Jung-Hyun Kim; Young Bong Kim; Haryoung Poo; Ssang-Goo Cho

doi:10.1007/s12275-014-4212-z

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Research Support, Non-U.S. Gov't
Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus: Mohammed Kawser Hossain ¹, Hye Yeon Choi ¹, Jae-Seon Hwang ², Ahmed Abdal Dayem ¹, Jung-Hyun Kim ¹, Young Bong Kim ³, Haryoung Poo ², Ssang-Goo Cho ¹; Journal of Microbiology 2014;52(6):521-526.
DOI: https://doi.org/10.1007/s12275-014-4212-z
Published online: May 29, 2014

¹Department of Animal Biotechnology, Animal Resources Research Center, and Incurable Disease Animal model and Stem cell Institute (IDASI), Konkuk University, Seoul 143-701, Republic of Korea, ²Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea, ³Department of Bioindustrial Technologies, Konkuk University, Seoul 143-701, Republic of Korea¹Department of Animal Biotechnology, Animal Resources Research Center, and Incurable Disease Animal model and Stem cell Institute (IDASI), Konkuk University, Seoul 143-701, Republic of Korea, ²Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea, ³Department of Bioindustrial Technologies, Konkuk University, Seoul 143-701, Republic of Korea

Corresponding author: Ssang-Goo Cho , Tel: +82-2-450-4207,

Received: 3 April 2014 • Revised: 21 April 2014 • Accepted: 21 April 2014

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Abstract

Influenza virus infection causes thousands of deaths and millions of hospitalizations worldwide every year and the emergence of resistance to anti-influenza drugs has prompted scientists to seek new natural antiviral materials. In this study, we screened 13 different flavonoids from various flavonoid groups to identify the most potent antiviral flavonoid against human influenza A/PR/8/34 (H1N1). The 3-hydroxyl group flavonoids, including 3,2'-dihydroxyflavone (3,2'-DHF) and 3,4'-dihydroxyflavone (3,4'-DHF), showed potent anti-influenza activity. They inhibited viral neuraminidase activity and viral adsorption onto cells. To confirm the anti-influenza activity of these flavonoids, we used an in vivo mouse model. In mice infected with human influenza, oral administration of 3,4'-DHF significantly decreased virus titers and pathological changes in the lung and reduced body weight loss and death. Our data suggest that 3-hydroxyl group flavonoids, particularly 3,4'-DHF, have potent antiviral activity against human influenza A/PR/8/34 (H1N1) in vitro and in vivo. Further clinical studies are needed to investigate the therapeutic and prophylactic potential of the 3-hydroxyl group flavonoids in treating influenza pandemics.

Keywords: flavonoid, 3-hydroxyl group flavonoids, 3,4'-dihydroxyflavone, influenza virus

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Antiviral Activity of 3,4'-Dihydroxyflavone on Influenza A Virus

J. Microbiol. 2014;52(6):521-526. Published online May 29, 2014

DOI: https://doi.org/10.1007/s12275-014-4212-z

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