Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model

Hwan Hee Lee; Heejin Park; Gi-Ho Sung; Kanghyo Lee; Taeho Lee; Ilseob Lee; Man-seong Park; Yong Woo Jung; Yu Su Shin; Hyojeung Kang; Hyosun Cho

doi:10.1007/s12275-014-4300-0

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Research Support, Non-U.S. Gov't
Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model: Hwan Hee Lee ¹, Heejin Park ², Gi-Ho Sung ³, Kanghyo Lee ³, Taeho Lee ⁴, Ilseob Lee ⁵, Man-seong Park ⁵, Yong Woo Jung ⁶, Yu Su Shin ⁷, Hyojeung Kang ², Hyosun Cho ¹; Journal of Microbiology 2014;52(8):696-701
DOI: https://doi.org/10.1007/s12275-014-4300-0
Published online: July 18, 2014

¹College of Pharmacy, Duksung Women’s University, Seoul 132-714, Republic of Korea, ²College of Pharmacy, Research Institute of Pharmaceutical Sciences and Institute for Microorganisms, Kyungpook National University, Daegu 702-701, Republic of Korea, ³Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea, ⁴Research Center, Dong-a Pharm. Co., LTD., Yongin 446-905, Republic of Korea, ⁵College of Medicine, Korea University, Seoul 136-705, Republic of Korea, ⁶College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea, ⁷Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea¹College of Pharmacy, Duksung Women’s University, Seoul 132-714, Republic of Korea, ²College of Pharmacy, Research Institute of Pharmaceutical Sciences and Institute for Microorganisms, Kyungpook National University, Daegu 702-701, Republic of Korea, ³Mushroom Research Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea, ⁴Research Center, Dong-a Pharm. Co., LTD., Yongin 446-905, Republic of Korea, ⁵College of Medicine, Korea University, Seoul 136-705, Republic of Korea, ⁶College of Pharmacy, Korea University, Sejong 339-700, Republic of Korea, ⁷Department of Medicinal Crop Research, National Institute of Horticultural and Herbal Science, Rural Development Administration, Eumseong 369-873, Republic of Korea

Corresponding author: Hyojeung Kang , Tel: +82-2-901-8678,
Hyosun Cho , Tel: +82-2-901-8678,

Received: 21 May 2014 • Revised: 12 June 2014 • Accepted: 13 June 2014

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Abstract

The immune-modulatory as well as anti-influenza effects of Cordyceps extract were investigated using a DBA/2 mouse model. Three different concentrations of Cordyceps extract, red ginseng extract, or drinking water were orally administered to mice for seven days, and then the mice were intranasally infected with 2009 pandemic influenza H1N1 virus. Body weight changes and survival rate were measured daily post-infection. Plasma IL-12, TNF-α, and the frequency of natural killer (NK) cells were measured on day 4 post-infection. The DBA/2 strain was highly susceptible to H1N1 virus infection. We also found that Cordyceps extract had an antiinfluenza effect that was associated with stable body weight and reduced mortality. The anti-viral effect of Cordyceps extract on influenza infection was mediated presumably by increased IL-12 expression and greater number of NK cells. However, high TNF-α expression after infection of H1N1 virus in mice not receiving treatment with Cordyceps extract suggested a two-sided effect of the extract on host immune regulation.

Keywords: Cordyceps extract; influenza A virus; IL-12; NK cells

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Anti-influenza Effect of Cordyceps militaris through Immunomodulation in a DBA/2 Mouse Model

J. Microbiol. 2014;52(8):696-701. Published online July 18, 2014

DOI: https://doi.org/10.1007/s12275-014-4300-0

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