Abstract
			
			The human gastrointestinal tract is colonized by multitudes
of microorganisms that exert beneficial effects on human
health. Mounting evidence suggests that intestinal microbiota
contributes to host resistance against enteropathogenic
bacterial infection. However, molecular details that account
for such an important role has just begun to be understood.
The commensal microbes in the intestine regulate gut homeostasis
through activating the development of host innate
immunity and producing molecules with antimicrobial activities
that directly inhibit propagation of pathogenic bacteria.
Understanding the protective roles of gut microbiota
will provide a better insight into the molecular basis that underlies
complicated interaction among host-pathogen-symbiont.
In this review, we highlighted recent findings that help
us broaden our knowledge of the intestinal ecosystem and
thereby come up with a better strategy for combating enteropathogenic
infection.			
						
						
					 
		
		
		 
		
			Citations
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- 
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            infection via modulation of intestinal immune response and gut microbiota
          
 Xiao Li, Xiaoxiao Wu, Wanqing Zang, Zhou Zhou, Wenwen Cui, Ying Chen, Huan Yang
 Virulence.2025;[Epub]     CrossRef
- Bacterial and fungal quorum sensing interactions with human cells; mechanisms and potential therapeutical applications
 Mona Sadat Mirtaleb, Behnaz Bakhshandeh, Fatemeh Mohammadipanah, Seyedeh Reihaneh Seyed Shirazi, Amir Reza Mobashery
 Microbial Pathogenesis.2025; 207: 107925.     CrossRef
- Probiotics for inflammatory bowel disease: Is there sufficient evidence?
 Yueying Ma, Dandan Yang, Jin Huang, Kunli Liu, Huirong Liu, Huangan Wu, Chunhui Bao
 Open Life Sciences.2024;[Epub]     CrossRef
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            Bifidobacterium longum
            to form the “golden shield” of the infant intestine: metabolic strategies, health effects, and mechanisms of action
          
 Shuo Yang, Junwu Cai, Qian Su, Qiaohui Li, Xiangchen Meng
 Gut Microbes.2024;[Epub]     CrossRef
- Effects of Interactions between Feeding Patterns and the Gut Microbiota on Pig Reproductive Performance
 Mingyu Wang, Jiaqi Yue, Guangquan Lv, Yaxin Wang, Ao Guo, Zhe Liu, Taiyong Yu, Gongshe Yang
 Animals.2024; 14(18): 2714.     CrossRef
- Effects of Clostridium butyricum on Growth Performance, Intestinal Health, and Disease Resistance of Hybrid Grouper (Epinephelus fuscoguttatus
                     ♀
                   × E. lanceolatus
                     ♂
                  ) Fed with C
 Ling Pan, Weikang Li, Ruitao Xie, Hongyu Liu, Beiping Tan, Xiaohui Dong, Qihui Yang, Shuyan Chi, Shuang Zhang, Erchao Li
 Aquaculture Nutrition.2023; 2023: 1.     CrossRef
- The resistome and microbiome of wastewater treatment plant workers – The AWARE study
 Fanny Berglund, Daloha Rodríguez-Molina, Gratiela Gradisteanu Pircalabioru, Hetty Blaak, Mariana-Carmen Chifiriuc, Ilda Czobor Barbu, Carl-Fredrik Flach, Irina Gheorghe-Barbu, Luminița Măruțescu, Marcela Popa, Ana Maria de Roda Husman, Laura Wengenroth, H
 Environment International.2023; 180: 108242.     CrossRef
- Developmental changes of nutrient digestion in young lambs are influenced by weaning and associated with intestinal microbiota
 Chong Li, Guoxiu Wang, Qian Zhang, Yongliang Huang, Fadi Li, Weimin Wang
 Animal Biotechnology.2023; 34(4): 1362.     CrossRef
- Glycolysis characteristics of intracellular polysaccharides from Agaricus bitorquis (Quél.) sacc. Chaidam and its effects on intestinal flora from different altitudes of mice in vitro fermentation
 Shicheng Hu, Ke Gao, Yingchun Jiao, Zhenzhen Yuan
 Food Research International.2023; 173: 113382.     CrossRef
- The role of γδ T cells in the interaction between commensal and pathogenic bacteria in the intestinal mucosa
 Xiaoxiao Wu, Bing Gu, Huan Yang
 International Reviews of Immunology.2023; 42(6): 379.     CrossRef
- Mass Spectrometric Analysis of Bioactive Conditioned Media of Bacteria Isolated From Reptilian Gut
 Ruqaiyyah Siddiqui, Noor Akbar, Nelson Cruz Soares, Hamza Mohammad Al-Hroub, Mohammad Harb Semreen, Sutherland K Maciver, Naveed Ahmed Khan
 Future Science OA.2023;[Epub]     CrossRef
- Alteration of the Gut Microbiota in Missed Abortion
 Yi Chen, Xianqian Chen, Pingyu Chen, Xiuxia Chen, Lin Pan, Lihong Han, Tang Zhu
 Indian Journal of Microbiology.2023; 63(1): 106.     CrossRef
- Early Weaning Stress Induces Intestinal Microbiota Disturbance, Mucosal Barrier Dysfunction and Inflammation Response Activation in Pigeon Squabs
 Qianqian Xu, Huafeng Jian, Wenyan Zhao, Jiankui Li, Xiaoting Zou, Xinyang Dong
 Frontiers in Microbiology.2022;[Epub]     CrossRef
- Gut barrier disruption and chronic disease
 Jan Martel, Shih-Hsin Chang, Yun-Fei Ko, Tsong-Long Hwang, John D. Young, David M. Ojcius
 Trends in Endocrinology & Metabolism.2022; 33(4): 247.     CrossRef
- Modulation of Intestinal Barrier, Inflammatory Response, and Gut Microbiota by Pediococcus pentosaceus zy-B Alleviates Vibrio parahaemolyticus Infection in C57BL/6J Mice
 Rundong Wang, Yijia Deng, Yuhao Zhang, Xuepeng Li, Lijun Sun, Qi Deng, Ying Liu, Ravi Gooneratne, Jianrong Li
 Journal of Agricultural and Food Chemistry.2022; 70(6): 1865.     CrossRef
- Cholangiocyte derived carcinomas and local microbiota
 Ariel A. Arteta, Martha Milanes‐Yearsley, Nora Cardona‐Castro
 Journal of Hepato-Biliary-Pancreatic Sciences.2022; 29(10): 1084.     CrossRef
- Progress and prospects of the healthy human gut virome
 Stephen R Stockdale, Colin Hill
 Current Opinion in Virology.2021; 51: 164.     CrossRef
- The Role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer Development
 Flavia Genua, Vedhika Raghunathan, Mazda Jenab, William M. Gallagher, David J. Hughes
 Frontiers in Oncology.2021;[Epub]     CrossRef
- An Escherichia coli strain with extra catalase activity protects against murine colitis by scavenging hydrogen peroxide and regulating regulatory t cell/interleukin-17 pathways
 Da Hye Kim, Jihye Park, Soochan Kim, Mi Young Yoon, Hyun Woo Ma, I.Seul Park, Mijeong Son, Ji Hyung Kim, Tae Il Kim, Won Ho Kim, Sang Sun Yoon, Seung Won Kim, Jae Hee Cheon
 Free Radical Biology and Medicine.2021; 174: 110.     CrossRef
- Description of Ornithinimicrobium ciconiae sp. nov., and Ornithinimicrobium avium sp. nov., isolated from the faeces of the endangered and near-threatened birds
 So-Yeon Lee, Hojun Sung, Pil Soo Kim, Hyun Sik Kim, Jae-Yun Lee, June-Young Lee, Yun-Seok Jeong, Euon Jung Tak, Jeong Eun Han, Dong-Wook Hyun, Jin-Woo Bae
 Journal of Microbiology.2021; 59(11): 978.     CrossRef
- Stimulation of Toll-Like Receptor 3 Diminishes Intracellular Growth of Salmonella Typhimurium by Enhancing Autophagy in Murine Macrophages
 Hyo-Ji Lee, Sun-Hye Lee, Ji-Hui Jeon, Hyo-Jung Kim, Eui-Kwon Jeong, Min-Jeong Kim, Young Mee Jung, Yu-Jin Jung
 Metabolites.2021; 11(9): 602.     CrossRef
- Infection prevention and control research priorities: what do we need to combat healthcare-associated infections and antimicrobial resistance? Results of a narrative literature review and survey analysis
 Yohann Lacotte, Christine Årdal, Marie-Cécile Ploy
 Antimicrobial Resistance & Infection Control.2020;[Epub]     CrossRef
- Microbiota–host interactions shape ageing dynamics
 Miriam Popkes, Dario Riccardo Valenzano
 Philosophical Transactions of the Royal Society B: Biological Sciences.2020; 375(1808): 20190596.     CrossRef
- Gut Microbiota: From the Forgotten Organ to a Potential Key Player in the Pathology of Alzheimer’s Disease
 Dong-Oh Seo, David M Holtzman, Michal Masternak
 The Journals of Gerontology: Series A.2020; 75(7): 1232.     CrossRef
- Interactions Between Rumen Microbes, VFAs, and Host Genes Regulate Nutrient Absorption and Epithelial Barrier Function During Cold Season Nutritional Stress in Tibetan Sheep
 Xiu Liu, Yuzhu Sha, Renqing Dingkao, Wei Zhang, Weibing Lv, Hong Wei, Hao Shi, Jiang Hu, Jiqing Wang, Shaobin Li, Zhiyun Hao, Yuzhu Luo
 Frontiers in Microbiology.2020;[Epub]     CrossRef
- Dual functional roles of the MyD88 signaling in colorectal cancer development
 Lu Wang, Kewei Yu, Xiang Zhang, Shuwen Yu
 Biomedicine & Pharmacotherapy.2018; 107: 177.     CrossRef
- Early-life sickness may predispose Siberian hamsters to behavioral changes following alterations of the gut microbiome in adulthood
 Kristyn E. Sylvia, Jessica E. Deyoe, Gregory E. Demas
 Brain, Behavior, and Immunity.2018; 73: 571.     CrossRef
- Effect of Early Weaning on the Intestinal Microbiota and Expression of Genes Related to Barrier Function in Lambs
 Chong Li, Weimin Wang, Ting Liu, Qian Zhang, Guoxiu Wang, Fadi Li, Fei Li, Xiangpeng Yue, Tingfu Li
 Frontiers in Microbiology.2018;[Epub]     CrossRef
- Guanosine tetra- and pentaphosphate increase antibiotic tolerance by reducing reactive oxygen species production in Vibrio cholerae
 Hwa Young Kim, Junhyeok Go, Kang-Mu Lee, Young Taek Oh, Sang Sun Yoon
 Journal of Biological Chemistry.2018; 293(15): 5679.     CrossRef
- A single gene of a commensal microbe affects host susceptibility to enteric infection
 Mi Young Yoon, Kyung Bae Min, Kang-Mu Lee, Yujin Yoon, Yaeseul Kim, Young Taek Oh, Keehoon Lee, Jongsik Chun, Byung-Yong Kim, Seok-Hwan Yoon, Insuk Lee, Chan Yeong Kim, Sang Sun Yoon
 Nature Communications.2016;[Epub]     CrossRef
- Antimicrobial Activity of Acidified Sodium Chlorite and Cell Free Culture Supernatent of Lactic Acid Bacteria against <i>Salmonella</i> Typhimurium
 Sangeeta Singh, Ajit Singh Yadav, Priyanka Bharti
 Journal of Biosciences and Medicines.2015; 03(11): 128.     CrossRef
- (p)ppGpp, a Small Nucleotide Regulator, Directs the Metabolic Fate of Glucose in Vibrio cholerae
 Young Taek Oh, Kang-Mu Lee, Wasimul Bari, David M. Raskin, Sang Sun Yoon
 Journal of Biological Chemistry.2015; 290(21): 13178.     CrossRef