Therapeutic potential of an AcHERV-HPV L1 DNA vaccine

Hee-Jung Lee; Jong Kwang Yoon; Yoonki Heo; Hansam Cho; Yeondong Cho; Yongdae Gwon; Kang Chang Kim; Jiwon Choi; Jae Sung Lee; Yu-Kyoung Oh; Young Bong Kim

doi:10.1007/s12275-015-5150-0

Articles

Page Path: HOME > J. Microbiol > Volume 53(6); 2015 > Article

Research Support, Non-U.S. Gov't
Therapeutic potential of an AcHERV-HPV L1 DNA vaccine: Hee-Jung Lee ¹, Jong Kwang Yoon ¹, Yoonki Heo ¹, Hansam Cho ¹, Yeondong Cho ¹, Yongdae Gwon ¹, Kang Chang Kim ¹, Jiwon Choi ¹, Jae Sung Lee ², Yu-Kyoung Oh ³, Young Bong Kim ¹; Journal of Microbiology 2015;53(6):415-420.
DOI: https://doi.org/10.1007/s12275-015-5150-0
Published online: May 30, 2015

¹Department of Bio-industrial Technologies, Konkuk University, Seoul 143-701, Republic of Korea, ²Kolon Life Science, Gyeonggi-do 427-709, Republic of Korea, ³College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea¹Department of Bio-industrial Technologies, Konkuk University, Seoul 143-701, Republic of Korea, ²Kolon Life Science, Gyeonggi-do 427-709, Republic of Korea, ³College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea

Corresponding author: Young Bong Kim , Tel: +82-2-450-4208,

Received: 23 March 2015 • Revised: 30 April 2015 • Accepted: 3 May 2015

48 Views
0 Download
6 Crossref
8 Scopus

Full Article

Abstract

Cervical cancer is strongly associated with chronic human papillomavirus infections, among which HPV16 is the most common. Two commercial HPV vaccines, Gardasil and Cervarix are effective for preventing HPV infection, but cannot be used to treat existing HPV infections. Previously, we developed a human endogenous retrovirus (HERV)-enveloped recombinant baculovirus capable of delivering the L1 genes of HPV types 16, 18, and 58 (AcHERV-HP16/18/58L1, AcHERV-HPV). Intramuscular administration of AcHERVHPV vaccines induced a strong cellular immune response as well as a humoral immune response. In this study, to examine the therapeutic effect of AcHERV-HPV in a mouse model, we established an HPV16 L1 expressing tumor cell line. Compared to Cervarix, immunization with AcHERVHPV greatly enhanced HPV16 L1-specific cytotoxic T lymphocytes (CTL) in C57BL/6 mice. Although vaccination could not remove preexisting tumors, strong CTL activity retarded the growth of inoculated tumor cells. These results indicate that AcHERV-HPV could serve as a potential therapeutic DNA vaccine against concurrent infection with HPV 16, 18, and 58.

Keywords: human papillomavirus;vaccine;immunity;cytotoxic T-lymphocytes;anti-tumor

Figure & Data

References

Citations

Citations to this article as recorded by

Current Updates on Cancer-Causing Types of Human Papillomaviruses (HPVs) in East, Southeast, and South Asia
Chichao Xia, Sile Li, Teng Long, Zigui Chen, Paul K. S. Chan, Siaw Shi Boon
Cancers.2021; 13(11): 2691. CrossRef
In Silico Design and Immunological Studies of Two Novel Multiepitope DNA-Based Vaccine Candidates Against High-Risk Human Papillomaviruses
Matin Kayyal, Azam Bolhassani, Zahra Noormohammadi, Majid Sadeghizadeh
Molecular Biotechnology.2021; 63(12): 1192. CrossRef
Unraveling the Genome-Wide Impact of Recombinant Baculovirus Infection in Mammalian Cells for Gene Delivery
Ha Youn Shin, Hanul Choi, Nahyun Kim, Nayoung Park, Heesun Kim, Jaebum Kim, Young Bong Kim
Genes.2020; 11(11): 1306. CrossRef
Treatment with Radix Euphorbiae Ebracteolatae Significantly Decreases the Expression of E6 and L1, and Increases the Expression of p53 and Rb in HPV18-infected Human Foreskin Keratinocytes
Xiang He, Xufeng He, Ping Xu, Lili Yang, Xin Ma, Wen Li, Huimin Zhang
Current Molecular Medicine.2019; 19(1): 20. CrossRef
Trial watch: DNA-based vaccines for oncological indications
Stefano Pierini, Renzo Perales-Linares, Mireia Uribe-Herranz, Jonathan G. Pol, Laurence Zitvogel, Guido Kroemer, Andrea Facciabene, Lorenzo Galluzzi
OncoImmunology.2017; 6(12): e1398878. CrossRef
Broad-spectrum antiviral properties of andrographolide
Swati Gupta, K. P. Mishra, Lilly Ganju
Archives of Virology.2017; 162(3): 611. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Therapeutic potential of an AcHERV-HPV L1 DNA vaccine

J. Microbiol. 2015;53(6):415-420. Published online May 30, 2015

DOI: https://doi.org/10.1007/s12275-015-5150-0

Related articles