MINIREVIEW] Multilayered regulations of RIG-I in the anti-viral signaling pathway

Nari Kim; Hesung Now; Nhung T.H. Nguyen; Joo-Yeon Yoo

doi:10.1007/s12275-016-6322-2

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MINIREVIEW] Multilayered regulations of RIG-I in the anti-viral signaling pathway: Nari Kim , Hesung Now , Nhung T.H. Nguyen , Joo-Yeon Yoo; Journal of Microbiology 2016;54(9):583-587.
DOI: https://doi.org/10.1007/s12275-016-6322-2
Published online: August 31, 2016

Department of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Republic of KoreaDepartment of Life Sciences, Pohang University of Science and Technology, Pohang 37673, Republic of Korea

Corresponding author: Nari Kim , Tel: -,
Joo-Yeon Yoo , Tel: -,

Received: 5 July 2016 • Revised: 9 August 2016 • Accepted: 9 August 2016

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Abstract

RIG-I is a cytosolic receptor recognizing virus-specific RNA structures and initiates an antiviral signaling that induces the production of interferons and proinflammatory cytokines. Because inappropriate RIG-I signaling affects either viral clearance or immune toxicity, multiple regulations of RIG-I have been investigated since its discovery as the viral RNA detector. In this review, we describe the recent progress in research on the regulation of RIG-I activity or abundance. Specifically, we focus on the mechanism that modulates RIGI- dependent antiviral response through post-translational modifications of or protein-protein interactions with RIG-I.

Keywords: RIG-I;antiviral signaling;RNA virus;post-translational modification;protein-protein interaction

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MINIREVIEW] Multilayered regulations of RIG-I in the anti-viral signaling pathway

J. Microbiol. 2016;54(9):583-587. Published online August 31, 2016

DOI: https://doi.org/10.1007/s12275-016-6322-2

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