MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication

Rak-Kyun Seong; Young-Ki Choi; Ok Sarah Shin

doi:10.1007/s12275-016-6383-2

Articles

Page Path: HOME > J. Microbiol > Volume 54(10); 2016 > Article

Journal Article
MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication: Rak-Kyun Seong ¹, Young-Ki Choi ², Ok Sarah Shin ¹; Journal of Microbiology 2016;54(10):695-700.
DOI: https://doi.org/10.1007/s12275-016-6383-2
Published online: September 30, 2016

¹Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul 08308, Republic of Korea, ²College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea¹Brain Korea 21 Plus for Biomedical Science, College of Medicine, Korea University, Seoul 08308, Republic of Korea, ²College of Medicine and Medical Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea

Corresponding author: Ok Sarah Shin , Tel: -,

Received: 11 August 2016 • Revised: 25 August 2016 • Accepted: 25 August 2016

prev next

73 Views
0 Download
14 Crossref
20 Scopus

Full Article

Abstract

Melanoma differentiation associated gene-7 (mda-7)/interleukin- 24 (IL-24) is a secreted cytokine, which plays an essential role in tumor suppression. Although its role as a multifunctional protein affecting broad types of cancers is well described, functions of IL-24 in host defense against virus infection are yet to be determined. In this study, we explored the anti-viral effect of recombinant IL-24 treatment during influenza infection. Infection of human lung adenocarcinoma cells (A549) with the influenza A virus up-regulated IL-24 mRNA and protein expression in a time-dependent manner. Pre-treatment of A549 cells with recombinant IL-24 protein effectively suppressed viral plaque formation. Furthermore, IL-24 treatment of A549 cells reduced viral non-structural protein 1 (NS1) synthesis, whereas IL-24 knockdown resulted in increased viral replication. Interestingly, IL-24 treatment following influenza A virus infection led to up-regulation of interferon (IFN)-induced antiviral signaling. Taken together, our results suggest that IL-24 exerts a potent suppressive effect on influenza viral replication and can be used in the treatment of influenza infection.

Keywords: IL-24;influenza;antiviral activities

Figure & Data

References

Citations

Citations to this article as recorded by

CXCR4/CXCL12 blockade therapy; a new horizon in TNBC therapy
Abdulrahman Qais Khaleel, Farag M. A. Altalbawy, Majid S. Jabir, Thikra F.Hasan, Vicky Jain, Vikrant Abbot, Prashant Nakash, M. Ravi Kumar, Yasser Fakri Mustafa, Mohammed Abed Jawad
Medical Oncology.2025;[Epub] CrossRef
Novel insight into MDA-7/IL-24: A potent therapeutic target for autoimmune and inflammatory diseases
Kangni Feng, Jiemei Cen, Xiaoling Zou, Tiantuo Zhang
Clinical Immunology.2024; 266: 110322. CrossRef
Interleukin-24 Limits Tumor-Infiltrating T Helper 17 Cell Response in Patients with Hepatitis B Virus-Related Hepatocellular Carcinoma
Minqi Zhang, Haifeng Zhao, Honglei Gao
Viral Immunology.2022; 35(3): 212. CrossRef
Host–virus interaction and viral evasion
Scheilla T. Strumillo, Denis Kartavykh, Fábio F. de Carvalho , Nicolly C. Cruz, Ana C. de Souza Teodoro, Ricardo Sobhie Diaz, Marli F. Curcio
Cell Biology International.2021; 45(6): 1124. CrossRef
SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response
Soo Jin Oh, Ok Sarah Shin
Cells.2021; 10(3): 530. CrossRef
Interleukin-24 as a Pulmonary Target Cytokine in Bronchopulmonary Dysplasia
Ruiwei Gao, Zhihua Li, Danyang Ai, Jinshuai Ma, Chao Chen, Xiuxiang Liu
Cell Biochemistry and Biophysics.2021; 79(2): 311. CrossRef
Pathogenesis and Potential Therapeutic Targets for Triple-Negative Breast Cancer
Chia-Jung Li, Yen-Dun Tony Tzeng, Yi-Han Chiu, Hung-Yu Lin, Ming-Feng Hou, Pei-Yi Chu
Cancers.2021; 13(12): 2978. CrossRef
MDA-7/interleukin 24 (IL-24) in tumor gene therapy: application of tumor penetrating/homing peptides for improvement of the effects
Mohammad Rasoolian, Majid Kheirollahi, Seyed Younes Hosseini
Expert Opinion on Biological Therapy.2019; 19(3): 211. CrossRef
Alternative Experimental Models for Studying Influenza Proteins, Host–Virus Interactions and Anti-Influenza Drugs
Sonja C. J. H. Chua, Hui Qing Tan, David Engelberg, Lina H. K. Lim
Pharmaceuticals.2019; 12(4): 147. CrossRef
HIV‐1 infection modulates IL‐24 expression which contributes to cell apoptosis in vitro
Scheilla Teixeira Strumillo, Marli Ferreira Curcio, Fábio Ferreira de Carvalho, MariaCecília Araripe Sucupira, Ricardo Sobhie Diaz, Hugo Pequeno Monteiro, Luiz Mário Ramos Janini
Cell Biology International.2019; 43(5): 574. CrossRef
Production of Interleukin-20 cytokines limits bacterial clearance and lung inflammation during infection by Streptococcus pneumoniae
Fahima Madouri, Olivia Barada, Gwenola Kervoaze, François Trottein, Muriel Pichavant, Philippe Gosset
EBioMedicine.2018; 37: 417. CrossRef
Inhibitory Effect and Mechanism of Mesenchymal Stem Cells Cultured in 3D System on Hepatoma Cells HepG2
Diandian Zhao, Lingling Hou, Mengwu Pan, Jilei Hua, Ziling Wang, Jinsheng He, Honggang Hu
Applied Biochemistry and Biotechnology.2018; 184(1): 212. CrossRef
Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas
Sangmin Kang, Jinjong Myoung
Journal of Microbiology.2017; 55(5): 319. CrossRef
Schlafen 14 (SLFN14) is a novel antiviral factor involved in the control of viral replication
Rak-Kyun Seong, Seong-wook Seo, Ji-Ae Kim, Sarah J. Fletcher, Neil V. Morgan, Mukesh Kumar, Young-Ki Choi, Ok Sarah Shin
Immunobiology.2017; 222(11): 979. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

MDA7/IL-24 is an anti-viral factor that inhibits influenza virus replication

J. Microbiol. 2016;54(10):695-700. Published online September 30, 2016

DOI: https://doi.org/10.1007/s12275-016-6383-2

Related articles