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HOME > J. Microbiol > Volume 55(3); 2017 > Article
Review
REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
Brian B. Gowen , Brady T. Hickerson
Journal of Microbiology 2017;55(3):183-195.
DOI: https://doi.org/10.1007/s12275-017-7029-8
Published online: February 28, 2017
Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USA
Corresponding author:  Brian B. Gowen , Tel: +1-435-797-3112, 
Received: 17 January 2017   • Revised: 6 February 2017   • Accepted: 6 February 2017
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Abstract

A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use. Here, we review recent progress in animal models of severe bunyaviral infections essential to this mission, as well as promising antivirals and biologicals that are at various stages of the development process.

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    REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies
    J. Microbiol. 2017;55(3):183-195.   Published online February 28, 2017
    DOI: https://doi.org/10.1007/s12275-017-7029-8
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