REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies

Brian B. Gowen; Brady T. Hickerson

doi:10.1007/s12275-017-7029-8

Articles

Page Path: HOME > J. Microbiol > Volume 55(3); 2017 > Article

Review
REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies: Brian B. Gowen , Brady T. Hickerson; Journal of Microbiology 2017;55(3):183-195.
DOI: https://doi.org/10.1007/s12275-017-7029-8
Published online: February 28, 2017

Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USADepartment of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan, Utah, 84326, USA

Corresponding author: Brian B. Gowen , Tel: +1-435-797-3112,

Received: 17 January 2017 • Revised: 6 February 2017 • Accepted: 6 February 2017

prev next

47 Views
0 Download
12 Crossref
18 Scopus

Full Article

Abstract

A growing number of bunyaviruses are known to cause viral hemorrhagic fever (VHF), a severe febrile illness which can progress to hypovolemic shock and multi-organ failure and is characterized by hematologic abnormalities and vascular leak. At present, there are no approved vaccines or antiviral therapies to effectively prevent or treat VHF caused by pathogenic bunyaviruses. Advances in the modeling of bunyaviral infections have facilitated efforts towards the development of novel post-exposure prophylactic and therapeutic countermeasures, several of which may some day be approved for human use. Here, we review recent progress in animal models of severe bunyaviral infections essential to this mission, as well as promising antivirals and biologicals that are at various stages of the development process.

Keywords: bunyavirus;Rift valley fever;severe fever with thrombocytopenia syndrome;Crimean-Congo hemorrhagic fever;hantavirus;antiviral

Figure & Data

References

Citations

Citations to this article as recorded by

Current insights into human pathogenic phenuiviruses and the host immune system
Chuan-Min Zhou, Ze-Zheng Jiang, Ning Liu, Xue-Jie Yu
Virulence.2024;[Epub] CrossRef
Digoxin is a potent inhibitor of Bunyamwera virus infection in cell culture
Beatriz Pacheco, Alberto Fernández-Oliva, Moisés García-Serradilla, Cristina Risco
Journal of General Virology .2023;[Epub] CrossRef
Design and evaluation of neutralizing and fusion inhibitory peptides to Crimean-Congo hemorrhagic fever virus
Megan C. Mears, Sergio E. Rodriguez, Katharina S. Schmitz, Angel Padilla, Sudipta Biswas, Maria N.B. Cajimat, Chad E. Mire, Stephen R. Welch, Éric Bergeron, Christopher A. Alabi, Matteo Porotto, Dennis A. Bente
Antiviral Research.2022; 207: 105401. CrossRef
Baseline mapping of Oropouche virology, epidemiology, therapeutics, and vaccine research and development
Megan A. Files, Clairissa A. Hansen, Vanessa C. Herrera, Craig Schindewolf, Alan D. T. Barrett, David W. C. Beasley, Nigel Bourne, Gregg N. Milligan
npj Vaccines.2022;[Epub] CrossRef
Chloroquine, an Anti-Malaria Drug as Effective Prevention for Hantavirus Infections
Valentijn Vergote, Lies Laenen, Raf Mols, Patrick Augustijns, Marc Van Ranst, Piet Maes
Frontiers in Cellular and Infection Microbiology.2021;[Epub] CrossRef
Light and electron microscopy imaging unveils new aspects of the antiviral capacity of silver nanoparticles in bunyavirus-infected cells
Moisés García-Serradilla, Cristina Risco
Virus Research.2021; 302: 198444. CrossRef
Antiviral Drugs Against Severe Fever With Thrombocytopenia Syndrome Virus Infection
Mutsuyo Takayama-Ito, Masayuki Saijo
Frontiers in Microbiology.2020;[Epub] CrossRef
Multimeric single-domain antibody complexes protect against bunyavirus infections
Paul J Wichgers Schreur, Sandra van de Water, Michiel Harmsen, Erick Bermúdez-Méndez, Dubravka Drabek, Frank Grosveld, Kerstin Wernike, Martin Beer, Andrea Aebischer, Olalekan Daramola, Sara Rodriguez Conde, Karen Brennan, Dorota Kozub, Maiken Søndergaard
eLife.2020;[Epub] CrossRef
Crimean-Congo hemorrhagic fever virus strains Hoti and Afghanistan cause viremia and mild clinical disease in cynomolgus monkeys
Robert W. Cross, Abhishek N. Prasad, Viktoriya Borisevich, Joan B. Geisbert, Krystle N. Agans, Daniel J. Deer, Karla A. Fenton, Thomas W. Geisbert, Waleed Saleh Al-Salem
PLOS Neglected Tropical Diseases.2020; 14(8): e0008637. CrossRef
High Prevalence of a Newly Discovered Wutai Mosquito Phasivirus in Mosquitoes from Rio de Janeiro, Brazil
Mário Sérgio Ribeiro, Tania Ayllón, Viviana Malirat, Daniel Cardoso Portela Câmara, Cristina Maria Giordano Dias, Guilherme Louzada, Davis Fernandes-Ferreira, Roberto de Andrade Medronho, Renata Campos Acevedo
Insects.2019; 10(5): 135. CrossRef
Parallel Survey of Two Widespread Renal Syndrome-Causing Zoonoses:Leptospiraspp. andHantavirusin Urban Environment, Hungary
Kornélia Kurucz, Mónika Madai, Dominika Bali, Dávid Hederics, Győző Horváth, Gábor Kemenesi, Ferenc Jakab
Vector-Borne and Zoonotic Diseases.2018; 18(4): 200. CrossRef
A lethal disease model for New World hantaviruses using immunosuppressed Syrian hamsters
Valentijn Vergote, Lies Laenen, Bert Vanmechelen, Marc Van Ranst, Erik Verbeken, Jay W. Hooper, Piet Maes, Michael R. Holbrook
PLOS Neglected Tropical Diseases.2017; 11(10): e0006042. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

REVIEW] Hemorrhagic fever of bunyavirus etiology: disease models and progress towards new therapies

J. Microbiol. 2017;55(3):183-195. Published online February 28, 2017

DOI: https://doi.org/10.1007/s12275-017-7029-8

Related articles