REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins

Megan E. Schmidt; Steven M. Varga

doi:10.1007/s12275-017-7045-8

Articles

Page Path: HOME > J. Microbiol > Volume 55(3); 2017 > Article

Review
REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins: Megan E. Schmidt ¹, Steven M. Varga ^1,2,3; Journal of Microbiology 2017;55(3):161-171.
DOI: https://doi.org/10.1007/s12275-017-7045-8
Published online: February 28, 2017

¹Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA, ²Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, ³Department of Pathology, University of Iowa, Iowa City, IA 52242, USA¹Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA, ²Department of Microbiology, University of Iowa, Iowa City, IA 52242, USA, ³Department of Pathology, University of Iowa, Iowa City, IA 52242, USA

Corresponding author: Steven M. Varga , Tel: +1-319-335-7784,

Received: 31 January 2017 • Accepted: 17 February 2017

41 Views
0 Download
25 Crossref
31 Scopus

Full Article

Abstract

Respiratory syncytial virus (RSV) causes severe respiratory disease in both the very young and the elderly. Nearly all individuals become infected in early childhood, and reinfections with the virus are common throughout life. Despite its clinical impact, there remains no licensed RSV vaccine. RSV infection in the respiratory tract induces an inflammatory response by the host to facilitate efficient clearance of the virus. However, the host immune response also contributes to the respiratory disease observed following an RSV infection. RSV has evolved several mechanisms to evade the host immune response and promote virus replication through interactions between RSV proteins and immune components. In contrast, some RSV proteins also play critical roles in activating, rather than suppressing, host immunity. In this review, we discuss the interactions between individual RSV proteins and host factors that modulate the immune response and the implications of these interactions for the course of an RSV infection.

Keywords: RSV;virus;T cell;lung;vaccine

Figure & Data

References

Citations

Citations to this article as recorded by

Intranasal Vaccination with a Respiratory-Syncytial-Virus-Based Virus-like Particle Displaying the G Protein Conserved Region Induces Severe Weight Loss and Pathology upon Challenge with Wildtype Respiratory Syncytial Virus
Megolhubino Terhüja, Manjunath Siddappa, Pramila Lamichhane, Chetan D. Meshram, Timothy A. Snider, Jerry W. Ritchey, Antonius G. P. Oomens
Viruses.2024; 16(6): 843. CrossRef
Immune Response to Respiratory Viral Infections
Antonella Gambadauro, Francesca Galletta, Alessandra Li Pomi, Sara Manti, Giovanni Piedimonte
International Journal of Molecular Sciences.2024; 25(11): 6178. CrossRef
Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort
Dylan Lawless, Christopher G McKennan, Suman R Das, Thomas Junier, Zhi Ming Xu, Larry J Anderson, Tebeb Gebretsadik, Meghan H Shilts, Emma Larkin, Christian Rosas-Salazar, James D Chappell, Jacques Fellay, Tina V Hartert
The Journal of Infectious Diseases.2023; 227(10): 1194. CrossRef
Circulation pattern and genetic variation of human respiratory syncytial virus in China during 2008–2021
Jingjing Song, Zhen Zhu, Jinhua Song, Naiying Mao, Aili Cui, Wenbo Xu, Yan Zhang
Journal of Medical Virology.2023;[Epub] CrossRef
Repurposing Axl Kinase Inhibitors for the Treatment of Respiratory Syncytial Virus Infection
Dan Zhang, Yuanhui Zhao, Xiaoxin You, Susu He, Erguang Li
Antimicrobial Agents and Chemotherapy.2023;[Epub] CrossRef
Activation of the Chemokine Receptor CCR1 and Preferential Recruitment of Gαi Suppress RSV Replication: Implications for Developing Novel Respiratory Syncytial Virus Treatment Strategies
Jiao Li, Ling Xue, Jiachao Wang, Aihong Meng, Jiajun Qiao, Miao Li, Xiuli Wang, Lingtong Meng, Jingyuan Ning, Xue Gao, Wenjian Li, Cuiqing Ma, Lin Wei, Bryan R. G. Williams
Journal of Virology.2022;[Epub] CrossRef
Mutation in the CX3C Motif of G Protein Disrupts Its Interaction with Heparan Sulfate: A Calorimetric, Spectroscopic, and Molecular Docking Study
Abu Hamza, Abdus Samad, Zahoor Ahmad Parray, Sajda Ara, Anwar Ahmed, Fahad N. Almajhdi, Tajamul Hussain, Asimul Islam, Shama Parveen
International Journal of Molecular Sciences.2022; 23(4): 1950. CrossRef
Innate Immune Responses to RSV Infection Facilitated by OGG1, an Enzyme Repairing Oxidatively Modified DNA Base Lesions
Xu Zheng, Ke Wang, Lang Pan, Wenjing Hao, Yaoyao Xue, Attila Bacsi, Spiros A. Vlahopoulos, Zsolt Radak, Tapas K. Hazra, Allan R. Brasier, Lloyd Tanner, Xueqing Ba, Istvan Boldogh
Journal of Innate Immunity.2022; 14(6): 593. CrossRef
Enhancing Anti-G Antibody Induction by a Live Single-Cycle Prefusion F—Expressing RSV Vaccine Improves In Vitro and In Vivo Efficacy
Pramila Lamichhane, Megolhubino Terhüja, Timothy A. Snider, Antonius G. P. Oomens
Viruses.2022; 14(11): 2474. CrossRef
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment
Dan Zhang, Yuanhui Zhao, Lingling Wang, Xiaoxin You, Jingjing Li, Guohai Zhang, Yayi Hou, Hongwei Wang, Susu He, Erguang Li
American Journal of Respiratory Cell and Molecular Biology.2022; 67(2): 227. CrossRef
A live single-cycle RSV vaccine expressing prefusion F protein
Pramila Lamichhane, Megan E. Schmidt, Megolhubino Terhüja, Steven M. Varga, Timothy A. Snider, Christina A. Rostad, Antonius G.P. Oomens
Virology.2022; 577: 51. CrossRef
Biophysical studies of the interaction of hRSV Non-Structural 1 protein with natural flavonoids and their acetylated derivatives by spectroscopic techniques and computational simulations
Isabella Ottenio de Lourenço, Evelyn Toscano Pedroso Quintino, Matheus Henrique Pereira, Caroline Sprengel Lima, Gabriela Campos Araújo, Luis Octávio Regasini, Fernando Alves de Melo, Fátima Pereira de Souza, Marcelo Andres Fossey, Ícaro Putinhon Caruso
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2022; 283: 121751. CrossRef
Pratensein glycoside attenuates respiratory syncytial virus infection-induced oxidative and inflammatory injury via TGF-β signaling pathway
Qiong Zhang, Si Li, Qiong Huang
Molecular & Cellular Toxicology.2022; 18(3): 329. CrossRef
Respiratory Syncytial Virus (RSV) G Protein Vaccines With Central Conserved Domain Mutations Induce CX3C-CX3CR1 Blocking Antibodies
Harrison C. Bergeron, Jackelyn Murray, Ana M. Nuñez Castrejon, Rebecca M. DuBois, Ralph A. Tripp
Viruses.2021; 13(2): 352. CrossRef
Juvenile, but Not Adult, Mice Display Increased Myeloid Recruitment and Extracellular Matrix Remodeling during Respiratory Syncytial Virus Infection
Gerald G. Kellar, Stephen R. Reeves, Kaitlyn A. Barrow, Jason S. Debley, Thomas N. Wight, Steven F. Ziegler
The Journal of Immunology.2020; 205(11): 3050. CrossRef
Double-edged role of natural killer cells during RSV infection
Rauf Bhat, Mohamed A. Farrag, Fahad N. Almajhdi
International Reviews of Immunology.2020; 39(5): 233. CrossRef
Disease severity of respiratory syncytial virus (RSV) infection correlate to a novel set of five amino acid substitutions in the RSV attachment glycoprotein (G) in China
Wanwei Li, Yanlan Wang, Bo Yu, Qiqi Tan, Jijian Zhou, Jingjing Hu, Yuanbin Wu, Bo Wang, Hongjian Li
Virus Research.2020; 281: 197937. CrossRef
Revisiting respiratory syncytial virus’s interaction with host immunity, towards novel therapeutics
C. Efstathiou, S. H. Abidi, J. Harker, N. J. Stevenson
Cellular and Molecular Life Sciences.2020; 77(24): 5045. CrossRef
Ephedrannin B exerts anti-viral and anti-inflammatory properties in BEAS-2B cells infected with respiratory syncytial virus
Shu Hou, Xiaoyan Xu, Yating Wang, Yan Yang
Journal of Biosciences.2020;[Epub] CrossRef
Vaccine containing G protein fragment and recombinant baculovirus expressing M2 protein induces protective immunity to respiratory syncytial virus
Yeong-Min Jo, Jungwoo Kim, Jun Chang
Clinical and Experimental Vaccine Research.2019; 8(1): 43. CrossRef
VITAMIN D LEVEL IN CRITICALLY ILL CHILDREN 6 MONTHS–5 YEARS AGE ADMITTED TO INTENSIVE CARE UNIT IN TERTIARY CARE HOSPITAL OF CENTRAL INDIA
AKSHAY ASHOK ., MANJUSHA GOEL ., BHARTI CHAUBEY ., RAJESH PATIL .
Indian Journal of Child Health.2019; 06(04): 413. CrossRef
Utility of the Neonatal Calf Model for Testing Vaccines and Intervention Strategies for Use against Human RSV Infection
Mariana Guerra-Maupome, Mitchell V. Palmer, Jodi L. McGill, Randy E. Sacco
Vaccines.2019; 7(1): 7. CrossRef
Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development
Seyhan Boyoglu-Barnum, Tatiana Chirkova, Larry J. Anderson
Frontiers in Immunology.2019;[Epub] CrossRef
Infant Viral Respiratory Infection Nasal Immune-Response Patterns and Their Association with Subsequent Childhood Recurrent Wheeze
Kedir N. Turi, Jyoti Shankar, Larry J. Anderson, Devi Rajan, Kelsey Gaston, Tebeb Gebretsadik, Suman R. Das, Cosby Stone, Emma K. Larkin, Christian Rosas-Salazar, Steven M. Brunwasser, Martin L. Moore, R. Stokes Peebles, Tina V. Hartert
American Journal of Respiratory and Critical Care Medicine.2018; 198(8): 1064. CrossRef
Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses
Virender Kumar Pal, Parijat Bandyopadhyay, Amit Singh
IUBMB Life.2018; 70(5): 393. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

REVIEW] Modulation of the host immune response by respiratory syncytial virus proteins

J. Microbiol. 2017;55(3):161-171. Published online February 28, 2017

DOI: https://doi.org/10.1007/s12275-017-7045-8

Related articles