[Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas

Sangmin Kang; Jinjong Myoung

doi:10.1007/s12275-017-7075-2

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[Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas: Sangmin Kang , Jinjong Myoung; Journal of Microbiology 2017;55(5):319-329.
DOI: https://doi.org/10.1007/s12275-017-7075-2
Published online: April 29, 2017

Korea Zoonosis Research Institute, Chonbuk National University, Jeonju 54896, Republic of KoreaKorea Zoonosis Research Institute, Chonbuk National University, Jeonju 54896, Republic of Korea

Corresponding author: Jinjong Myoung , Tel: +82-63-900-4055,

Received: 17 February 2017 • Revised: 3 March 2017 • Accepted: 3 March 2017

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Abstract

Kaposi’s sarcoma-associated herpesvirus (KSHV) is the latest addition to the human herpesvirus family. Unlike alpha- and beta-herpesvirus subfamily members, gamma-herpesviruses, including Epstein-Barr virus (EBV) and KSHV, cause vari-ous tumors in humans. KSHV primarily infects endothelial and B cells in vivo, and is associated with at least three malig-nancies: Kaposi’s sarcoma and two B cell lymphomas, res-pectively. Although KSHV readily infects endothelial cells in vitro and thus its pathogenic mechanisms have been exten-sively studied, B cells had been refractory to KSHV infection. As such, functions of KSHV genes have mostly been eluci-dated in endothelial cells in the context of viral infection but not in B cells. Whether KSHV oncogenes, defined in endo-thelial cells, play the same roles in the tumorigenesis of B cells remains an open question. Only recently, through a few ground-breaking studies, B cell infection models have been established. In this review, those models will be compared and contrasted and putative mechanisms of KSHV-induced B cell transformation will be discussed.

Keywords: KSHV;B cell;infection model;lymphoma

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[Minireview] Primary lymphocyte infection models for KSHV and its putative tumorigenesis mechanisms in B cell lymphomas

J. Microbiol. 2017;55(5):319-329. Published online April 29, 2017

DOI: https://doi.org/10.1007/s12275-017-7075-2

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