An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

Seong Eun Jin; Jung-Eun Kim; Sun Yeou Kim; Bang Ju Park; Yoon-Jae Song

doi:10.1007/s12275-017-7477-1

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An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication: Seong Eun Jin ¹, Jung-Eun Kim ¹, Sun Yeou Kim ^2,3, Bang Ju Park ⁴, Yoon-Jae Song ¹; Journal of Microbiology 2017;55(12):984-988
DOI: https://doi.org/10.1007/s12275-017-7477-1
Published online: December 7, 2017

¹Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea, ²College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea, ³Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea, ⁴Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea¹Department of Life Science, Gachon University, Seongnam 13120, Republic of Korea, ²College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea, ³Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 21936, Republic of Korea, ⁴Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea

Corresponding author: Yoon-Jae Song , Tel: +82-31-750-8731,

Received: 6 November 2017 • Revised: 14 November 2017 • Accepted: 15 November 2017

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Abstract

Hepatitis E virus (HEV) is an etiological agent of acute hepatitis E, a self-limiting disease prevalent in developing countries. HEV can cause fulminant hepatic failure with high mortality rates in pregnant women, and genotype 3 is reported to trigger chronic hepatitis in immunocompromised individuals worldwide. Screening of plant extracts for compounds with potential anti-HEV effects led to the identification of a 70% ethanol extract of Lysimachia mauritiana (LME) that interferes with replication of the swine HEV genotype 3 replicon. Furthermore, LME significantly inhibited replication of HEV genotype 3 and expression of HEV ORF2 in infected cells without exerting cytotoxic effects. Collectively, our findings demonstrate the potential utility of LME in the development of novel antiviral drugs against HEV infection.

Keywords: hepatitis E virus; antiviral; Lysimachia mauritiana

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An ethanol extract of Lysimachia mauritiana exhibits inhibitory activity against hepatitis E virus genotype 3 replication

J. Microbiol. 2017;55(12):984-988. Published online December 7, 2017

DOI: https://doi.org/10.1007/s12275-017-7477-1

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