REVIEW] Type 3 regulatory T cells at the interface of symbiosis

Joo-Hong Park; Gérard Eberl

doi:10.1007/s12275-018-7565-x

Articles

Page Path: HOME > J. Microbiol > Volume 56(3); 2018 > Article

Review
REVIEW] Type 3 regulatory T cells at the interface of symbiosis: Joo-Hong Park ^1,2, Gérard Eberl ^1,2; Journal of Microbiology 2018;56(3):163-171.
DOI: https://doi.org/10.1007/s12275-018-7565-x
Published online: February 28, 2018

¹Microenvironment and Immunity Unit, Institut Pasteur, 75724 Paris, France, ²INSERM U1224, 75724 Paris, France¹Microenvironment and Immunity Unit, Institut Pasteur, 75724 Paris, France, ²INSERM U1224, 75724 Paris, France

Corresponding author: Joo-Hong Park , Tel: +33-1-4061-3223,
Gérard Eberl , Tel: +33-1-4061-3223,

Received: 25 December 2017 • Revised: 30 January 2018 • Accepted: 5 February 2018

prev next

50 Views
0 Download
20 Crossref
22 Scopus

Full Article

Abstract

The mammalian gastrointestinal tract accommodates trillions of bacteria, many of which provide beneficial effects to the host, including protection from pathogenic microorganisms and essential metabolites. However, the intestinal immune system needs to adapt to the constantly fluctuating microbial environment at mucosal surfaces in order to maintain homeostasis. In particular, the gut microbiota induces the differentiation of effector Th17 cells and regulatory T cells (Tregs) that express RORγt, the master regulator of antimicrobial type 3 immunity. RORγt+ Tregs constitute a major population of colonic Tregs that is distinct from thymusderived Tregs and require bacterial antigens for differentiation. The balance between Th17 cells and RORγt+ Tregs, that is, the tone of the local type 3 immune response, is regulated by the vitamin A metabolite retinoic acid produced by the host. Furthermore, Th17 cells and RORγt+ Tregs regulate intestinal type 2 immune responses, explaining how bacteria block allergic reactions. Here, we review the cellular and molecular mechanisms involved in the differentiation, regulation and function of RORγt+ (type 3) Tregs, and discuss the multiple equilibria that exist between effector T cells and Tregs, as well as between different types of immune responses, which are necessary to maintain homeostasis and health.

Keywords: regulatory T cells;RORγt;microbiota;mucosal immunity;homeostasis

Figure & Data

References

Citations

Citations to this article as recorded by

Viral Liver Disease and Intestinal Gut–Liver Axis
Elias Kouroumalis, Ioannis Tsomidis, Argyro Voumvouraki
Gastrointestinal Disorders.2024; 6(1): 64. CrossRef
Fecal microbiota transplantation for treatment of non-alcoholic fatty liver disease: Mechanism, clinical evidence, and prospect
Xiao-Xia Qiu, Sheng-Li Cheng, Yan-Hui Liu, Yu Li, Rui Zhang, Nan-Nan Li, Zheng Li
World Journal of Gastroenterology.2024; 30(8): 833. CrossRef
Endotoxin Inflammatory Action on Cells by Dysregulated-Immunological-Barrier-Linked ROS-Apoptosis Mechanisms in Gut–Liver Axis
Andrei Dumitru, Elena Matei, Georgeta Camelia Cozaru, Anca Chisoi, Luana Alexandrescu, Răzvan Cătălin Popescu, Mihaela Pundiche Butcaru, Eugen Dumitru, Sorin Rugină, Cristina Tocia
International Journal of Molecular Sciences.2024; 25(5): 2472. CrossRef
MAFLD and Celiac Disease in Children
Serena Scapaticci, Annamaria Venanzi, Francesco Chiarelli, Cosimo Giannini
International Journal of Molecular Sciences.2023; 24(2): 1764. CrossRef
Impacts of maternal microbiota and microbial metabolites on fetal intestine, brain, and placenta
Aleksi Husso, Tiina Pessa-Morikawa, Ville Mikael Koistinen, Olli Kärkkäinen, Hyuk Nam Kwon, Leo Lahti, Antti Iivanainen, Kati Hanhineva, Mikael Niku
BMC Biology.2023;[Epub] CrossRef
Gut microbiome as a therapeutic target for liver diseases
Tejinder Pal Singh, Saurabh Kadyan, Harisha Devi, Gwoncheol Park, Ravinder Nagpal
Life Sciences.2023; 322: 121685. CrossRef
Contribution of the microbiome for better phenotyping of people living with obesity
Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Gabriella Garruti, Piero Portincasa
Reviews in Endocrine and Metabolic Disorders.2023; 24(5): 839. CrossRef
The Role of the Gastrointestinal Microbiome in Liver Disease
Nicholas Shalaby, Dorit Samocha-Bonet, Nadeem O. Kaakoush, Mark Danta
Pathogens.2023; 12(9): 1087. CrossRef
The role of microbiota in nonalcoholic fatty liver disease
Agostino Di Ciaula, Leonilde Bonfrate, Piero Portincasa
European Journal of Clinical Investigation.2022;[Epub] CrossRef
Intestinal Barrier and Permeability in Health, Obesity and NAFLD
Piero Portincasa, Leonilde Bonfrate, Mohamad Khalil, Maria De Angelis, Francesco Maria Calabrese, Mauro D’Amato, David Q.-H. Wang, Agostino Di Ciaula
Biomedicines.2021; 10(1): 83. CrossRef
A Pulmonary Lactobacillus murinus Strain Induces Th17 and RORγt+ Regulatory T Cells and Reduces Lung Inflammation in Tuberculosis
Lucie Bernard-Raichon, André Colom, Sarah C. Monard, Amine Namouchi, Margaux Cescato, Hugo Garnier, Stephen A. Leon-Icaza, Arnaud Métais, Alexia Dumas, Dan Corral, Natsinet Ghebrendrias, Pauline Guilloton, Christel Vérollet, Denis Hudrisier, Aude Remot, P
The Journal of Immunology.2021; 207(7): 1857. CrossRef
Microbiota-mediated protection against antibiotic-resistant pathogens
Rekha B. Panwar, Richard P. Sequeira, Thomas B. Clarke
Genes & Immunity.2021; 22(5-6): 255. CrossRef
Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells
Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Oishi-Ohno, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi
Life Science Alliance.2020; 3(1): e201900441. CrossRef
Regulatory T cells control the dynamic and site-specific polarization of total CD4 T cells following Salmonella infection
Slater L. Clay, Alberto Bravo-Blas, Daniel M. Wall, Megan K.L. MacLeod, Simon W.F. Milling
Mucosal Immunology.2020; 13(6): 946. CrossRef
The gut-liver axis in liver disease: Pathophysiological basis for therapy
Agustín Albillos, Andrea de Gottardi, María Rescigno
Journal of Hepatology.2020; 72(3): 558. CrossRef
Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk
Agostino Di Ciaula, Jacek Baj, Gabriella Garruti, Giuseppe Celano, Maria De Angelis, Helen H. Wang, Domenica Maria Di Palo, Leonilde Bonfrate, David Q-H Wang, Piero Portincasa
Journal of Clinical Medicine.2020; 9(8): 2648. CrossRef
Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis
Margherita T. Cantorna, Lindsay Snyder, Juhi Arora
Critical Reviews in Biochemistry and Molecular Biology.2019; 54(2): 184. CrossRef
Gut microbiomes and their metabolites shape human and animal health
Woojun Park
Journal of Microbiology.2018; 56(3): 151. CrossRef
Regulatory B and T lymphocytes in multiple sclerosis: friends or foes?
Georgios K. Vasileiadis, Efthymios Dardiotis, Athanasios Mavropoulos, Zisis Tsouris, Vana Tsimourtou, Dimitrios P. Bogdanos, Lazaros I. Sakkas, Georgios M. Hadjigeorgiou
Autoimmunity Highlights.2018;[Epub] CrossRef
Classic Models for New Perspectives: Delving into Helminth–Microbiota–Immune System Interactions
Alba Cortés, Rafael Toledo, Cinzia Cantacessi
Trends in Parasitology.2018; 34(8): 640. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

REVIEW] Type 3 regulatory T cells at the interface of symbiosis

J. Microbiol. 2018;56(3):163-171. Published online February 28, 2018

DOI: https://doi.org/10.1007/s12275-018-7565-x

Related articles