Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus

Yoonki Heo; Yeondong Cho; Kwon sung Ju; Hansam Cho; Ki Hoon Park; Hanul Choi; Jong Kwang Yoon; Chiung Moon; Young Bong Kim

doi:10.1007/s12275-018-8222-0

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Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus: Yoonki Heo ¹, Yeondong Cho ¹, Kwon sung Ju ¹, Hansam Cho ¹, Ki Hoon Park ¹, Hanul Choi ¹, Jong Kwang Yoon ¹, Chiung Moon ², Young Bong Kim ³; Journal of Microbiology 2018;56(8):586-592.
DOI: https://doi.org/10.1007/s12275-018-8222-0
Published online: July 25, 2018

¹Department of Bio-industrial technologies, Konkuk University, Seoul 05029, Republic of Korea, ²Gueulri, Ansan 15588, Republic of Korea, ³Department of Bio-medical science and engineering, Konkuk University, Seoul 05029, Republic of Korea¹Department of Bio-industrial technologies, Konkuk University, Seoul 05029, Republic of Korea, ²Gueulri, Ansan 15588, Republic of Korea, ³Department of Bio-medical science and engineering, Konkuk University, Seoul 05029, Republic of Korea

Corresponding author: Young Bong Kim , Tel: +82-2-450-4208;,

Received: 30 April 2018 • Revised: 8 June 2018 • Accepted: 11 June 2018

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Abstract

The emergence of oseltamivir-resistant variants of influenza virus has highlighted the necessity for the development of more effective novel antiviral drugs. To date, numerous researchers have focused on developing antiviral drugs using natural resources, such as traditional herbal medicines. Poncirus trifoliata is widely used in oriental medicine as a remedy for gastritis, dysentery, inflammation and digestive ulcers. In this study, we investigated the potential antiviral effect of the Poncirus trifoliata orange seed extract against influenza virus. An ethanol extract of Poncirus trifoliata seeds (PTex) inhibited the activity of influenza viruses, in particular, oseltamivir- resistant strains, in Madin-Darby canine kidney cells. In contrast to oseltamivir, PTex exerted a significant inhibitory effect on the cellular penetration pathway of the virus rather than HA receptor binding. The potent antiviral effect and novel working mechanism of PTex support its further development as an effective natural antiviral drug with a wide spectrum of activity against influenza and oseltamivir-resistant viruses.

Keywords: influenza;Poncirus trifoliata;antiviral agent;natural product

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Antiviral activity of Poncirus trifoliata seed extract against oseltamivirresistant influenza virus

J. Microbiol. 2018;56(8):586-592. Published online July 25, 2018

DOI: https://doi.org/10.1007/s12275-018-8222-0

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