Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons

Yee Ching Ng; Ye Won Kim; Jeong-Su Lee; Sung Joon Lee; Moon Jung Song

doi:10.1007/s12275-018-8228-7

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Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons: Yee Ching Ng ¹, Ye Won Kim ², Jeong-Su Lee ³, Sung Joon Lee ², Moon Jung Song ¹; Journal of Microbiology 2018;56(9):683-689.
DOI: https://doi.org/10.1007/s12275-018-8228-7
Published online: August 23, 2018

¹Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea, ²Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea, ³Food Microbiology Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong 28159, Republic of Korea¹Virus-Host Interactions Laboratory, Department of Biosystems and Biotechnology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea, ²Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea, ³Food Microbiology Division, Food Safety Evaluation Department, National Institute of Food and Drug Safety Evaluation, Osong 28159, Republic of Korea

Corresponding author: Moon Jung Song , Tel: +82-2-3290-3019,

Received: 27 April 2018 • Revised: 11 May 2018 • Accepted: 21 May 2018

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Abstract

Human noroviruses are the causative agents of non-bacterial gastroenteritis worldwide. The rapid onset and resolution of disease symptoms suggest that innate immune responses are critical for controlling norovirus infection; however, no effective antivirals are yet available. The present study was conducted to examine the antiviral activities of Schizonepeta tenuifolia Briquet extract (STE) against noroviruses. Treatment of human norovirus replicon-bearing HG23 cells with STE at 5 and 10 mg/ml concentrations resulted in the reduction in the viral RNA levels by 77.2% and 85.9%, respectively. STE had no cytotoxic effects on HG23 cells. Treatment of RAW 264.7 cells infected with murine norovirus 1 (MNV-1), a surrogate virus of human noroviruses, with STE at 10 and 20 μg/ml concentrations resulted in the reduction of viral replication by 58.5% and 84.9%, respectively. STE treatment induced the expression of mRNAs for type I and type II interferons in HG23 cells and upregulated the transcription of interferon-β in infected RAW 264.7 cells via increased phosphorylation of interferon regulatory factor 3, a critical transcription regulator for type I interferon production. These
results
suggest that STE inhibits norovirus replication through the induction of antiviral interferon production during virus replication and may serve as a candidate antiviral substance for treatment against noroviruses.

Keywords: antiviral activity;norovirus;Schizonepeta tenuifolia Briquet (ST);natural phytochemicals;interferons

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Antiviral activity of Schizonepeta tenuifolia Briquet against noroviruses via induction of antiviral interferons

J. Microbiol. 2018;56(9):683-689. Published online August 23, 2018

DOI: https://doi.org/10.1007/s12275-018-8228-7

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