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REVIEW] Antibacterial strategies inspired by the oxidative stress and response networks
So Youn Kim , Chanseop Park , Hye-Jeong Jang , Bi-o Kim , Hee-Won Bae , In-Young Chung , Eun Sook Kim , You-Hee Cho
Journal of Microbiology 2019;57(3):203-212.
DOI: https://doi.org/10.1007/s12275-019-8711-9
Published online: February 26, 2019
Department of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Republic of KoreaDepartment of Pharmacy, College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam 13488, Republic of Korea
Corresponding author:  You-Hee Cho , Tel: +82-31-881-7165, 
Received: 28 December 2018   • Revised: 30 January 2019   • Accepted: 31 January 2019
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Abstract

Oxidative stress arises from an imbalance between the excessive accumulation of reactive oxygen species (ROS) and a cell’s capability to readily detoxify them. Although ROS are spontaneously generated during the normal oxygen respiration and metabolism, the ROS generation is usually augmented by redox-cycling agents, membrane disrupters, and bactericidal antibiotics, which contributes their antimicrobial bioactivity. It is noted that all the bacteria deploy an arsenal of inducible antioxidant defense systems to cope with the devastating effect exerted by the oxidative stress: these systems include the antioxidant effectors such as catalases and the master regulators such as OxyR. The oxidative stress response is not essential for normal growth, but critical to survive the oxidative stress conditions that the bacterial pathogens may encounter due to the host immune response and/or the antibiotic treatment. Based on these, we here define the ROS-inspired antibacterial strategies to enhance the oxidative stress of ROS generation and/or to compromise the bacterial response of ROS detoxification, by delineating the ROSgenerating antimicrobials and the core concept of the bacterial response against the oxidative stress.

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    REVIEW] Antibacterial strategies inspired by the oxidative stress and response networks
    J. Microbiol. 2019;57(3):203-212.   Published online February 26, 2019
    DOI: https://doi.org/10.1007/s12275-019-8711-9
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