REVIEW] Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system

Inseong Jo; Jin-Sik Kim; Yongbin Xu; Jaekyung Hyun; Kangseok Lee; Nam-Chul Ha

doi:10.1007/s12275-019-8520-1

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REVIEW] Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system: Inseong Jo ¹, Jin-Sik Kim ², Yongbin Xu ³, Jaekyung Hyun ⁴, Kangseok Lee ⁵, Nam-Chul Ha ¹; Journal of Microbiology 2019;57(3):185-194.
DOI: https://doi.org/10.1007/s12275-019-8520-1
Published online: February 26, 2019

¹Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, Center for Food and Bioconvergence, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea, ²Unit on Structural and Chemical Biology of Membrane Proteins, Cell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, ³Department of Bioengineering, College of Life Science, Dalian Minzu University, Dalian, 116600, Liaoning, P. R. China, ⁴Electron Microscopy Research Center, Korea Basic Science Institute, Cheongju 28119, Republic of Korea, ⁵Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea¹Department of Agricultural Biotechnology, Center for Food Safety and Toxicology, Center for Food and Bioconvergence, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea, ²Unit on Structural and Chemical Biology of Membrane Proteins, Cell Biology and Neurobiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA, ³Department of Bioengineering, College of Life Science, Dalian Minzu University, Dalian, 116600, Liaoning, P. R. China, ⁴Electron Microscopy Research Center, Korea Basic Science Institute, Cheongju 28119, Republic of Korea, ⁵Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea

Corresponding author: Nam-Chul Ha , Tel: +82-2-880-4853,

Received: 20 September 2018 • Revised: 26 December 2018 • Accepted: 10 January 2019

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Abstract

Tripartite efflux pumps and the type I secretion system of Gram-negative bacteria are large protein complexes that span the entire cell envelope. These complexes expel antibiotics and other toxic substances or transport protein toxins from bacterial cells. Elucidating the binary and ternary complex structures at an atomic resolution are crucial to understanding the assembly and working mechanism. Recent advances in cryoelectron microscopy along with the construction of chimeric proteins drastically shifted the assembly models. In this review, we describe the current assembly models from a historical perspective and emphasize the common assembly mechanism for the assembly of diverse tripartite pumps and type I secretion systems.

Keywords: multidrug resistance;multidrug efflux pump;structure;cryo-electron microscopy

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REVIEW] Recent paradigm shift in the assembly of bacterial tripartite efflux pumps and the type I secretion system

J. Microbiol. 2019;57(3):185-194. Published online February 26, 2019

DOI: https://doi.org/10.1007/s12275-019-8520-1

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