[MINIREVIEW] The nature of meiotic chromosome dynamics and recombination in budding yeast

Soogil Hong; Jeong Hwan Joo; Hyeseon Yun; Keunpil Kim

doi:10.1007/s12275-019-8541-9

Articles

Page Path: HOME > J. Microbiol > Volume 57(4); 2019 > Article

Review
[MINIREVIEW] The nature of meiotic chromosome dynamics and recombination in budding yeast: Soogil Hong , Jeong Hwan Joo , Hyeseon Yun , Keunpil Kim; Journal of Microbiology 2019;57(4):221-231.
DOI: https://doi.org/10.1007/s12275-019-8541-9
Published online: January 22, 2019

Department of Life Science, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea

Corresponding author: Keunpil Kim , Tel: +82-2-820-5792,

Received: 28 September 2018 • Revised: 24 October 2018 • Accepted: 26 October 2018

74 Views
0 Download
20 Web of Science
19 Crossref
20 Scopus

Full Article

Abstract

During meiosis, crossing over allows for the exchange of genes between homologous chromosomes, enabling their segregation and leading to genetic variation in the resulting gametes. Spo11, a topoisomerase-like protein expressed in eukaryotes, and diverse accessory factors induce programmed doublestrand breaks (DSBs) to initiate meiotic recombination during the early phase of meiosis after DNA replication. DSBs are further repaired via meiosis-specific homologous recombination. Studies on budding yeast have provided insights into meiosis and genetic recombination and have improved our understanding of higher eukaryotic systems. Cohesin, a chromosome-associated multiprotein complex, mediates sister chromatid cohesion (SCC), and is conserved from yeast to humans. Diverse cohesin subunits in budding yeast have been identified in DNA metabolic pathways, such as DNA replication, chromosome segregation, recombination, DNA repair, and gene regulation. During cell cycle, SCC is established by multiple cohesin subunits, which physically bind sister chromatids together and modulate proteins that involve in the capturing and separation of sister chromatids. Cohesin components include at least four core subunits that establish and maintain SCC: two structural maintenance chromosome subunits (Smc1 and Smc3), an α-kleisin subunit (Mcd1/Scc1 during mitosis and Rec8 during meiosis), and Scc3/Irr1 (SA1 and SA2). In addition, the cohesin-associated factors Pds5 and Rad61 regulate structural modifications and cell cyclespecific dynamics of chromatin to ensure accurate chromosome segregation. In this review, we discuss SCC and the recombination pathway, as well as the relationship between the two processes in budding yeast, and we suggest a possible conserved mechanism for meiotic chromosome dynamics from yeast to humans.

Keywords: meiosis;yeast;recombination;sister chromatid cohesion;cohesin

Figure & Data

References

Citations

Citations to this article as recorded by

RPA interacts with Rad52 to promote meiotic crossover and noncrossover recombination
Jeong H Joo, Soogil Hong, Mika T Higashide, Eui-Hwan Choi, Seobin Yoon, Min-Su Lee, Hyun Ah Kang, Akira Shinohara, Nancy Kleckner, Keun P Kim
Nucleic Acids Research.2024; 52(7): 3794. CrossRef
Elevated expression of exogenous RAD51 enhances the CRISPR/Cas9-mediated genome editing efficiency
Seo Jung Park, Seobin Yoon, Eui-Hwan Choi, Hana Hyeon, Kangseok Lee, Keun Pil Kim
BMB Reports.2023; 56(2): 102. CrossRef
Strategies to improve genome editing efficiency in crop plants
B. Aravind, Kutubuddin Molla, Satendra K. Mangrauthia, Gireesha Mohannath
Journal of Plant Biochemistry and Biotechnology.2023; 32(4): 661. CrossRef
A Method for Physical Analysis of Recombination Intermediates in Saccharomyces cerevisiae
Kiwon Rhee, Hyungseok Choi, Keun P. Kim, Jeong H. Joo
Journal of Microbiology.2023; 61(11): 939. CrossRef
The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells
Young Eun Koh, Eui-Hwan Choi, Jung-Woong Kim, Keun Pil Kim
Molecules and Cells.2022; 45(11): 820. CrossRef
Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control
Tina L. Sing, Gloria A. Brar, Elçin Ünal
Annual Review of Genetics.2022; 56(1): 89. CrossRef
Yeast polyubiquitin unit regulates synaptonemal complex formation and recombination during meiosis
Min-Kyung Jo, Kiwon Rhee, Keun Pil Kim, Soogil Hong
Journal of Microbiology.2022; 60(7): 705. CrossRef
Histone variant H2A.Z promotes meiotic chromosome axis organization in Saccharomyces cerevisiae
Lorencia Chigweshe, Amy J MacQueen, Scott G Holmes, J Berman
G3 Genes|Genomes|Genetics.2022;[Epub] CrossRef
Meiosis-specific cohesin complexes display essential and distinct roles in mitotic embryonic stem cell chromosomes
Eui-Hwan Choi, Seobin Yoon, Young Eun Koh, Tae Kyung Hong, Jeong Tae Do, Bum-Kyu Lee, Yoonsoo Hahn, Keun P. Kim
Genome Biology.2022;[Epub] CrossRef
Meiotic prophase roles of Pds5 in recombination and chromosome condensation in budding yeast
Jeong Hwan Joo, Hyun Ah Kang, Keun Pil Kim, Soogil Hong
Journal of Microbiology.2022; 60(2): 177. CrossRef
The multiple roles of RAB GTPases in female and male meiosis
Meng-Meng Shan, Shao-Chen Sun
Human Reproduction Update.2021; 27(6): 1013. CrossRef
The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation
Min-Su Lee, Mika T Higashide, Hyungseok Choi, Ke Li, Soogil Hong, Kangseok Lee, Akira Shinohara, Miki Shinohara, Keun P Kim
Nucleic Acids Research.2021; 49(13): 7537. CrossRef
Maintenance of genome integrity and active homologous recombination in embryonic stem cells
Eui-Hwan Choi, Seobin Yoon, Young Eun Koh, Young-Jin Seo, Keun Pil Kim
Experimental & Molecular Medicine.2020; 52(8): 1220. CrossRef
From coins to cancer therapy: Gold, silver and copper complexes targeting human topoisomerases
Jessica Ceramella, Annaluisa Mariconda, Domenico Iacopetta, Carmela Saturnino, Alexia Barbarossa, Anna Caruso, Camillo Rosano, Maria Stefania Sinicropi, Pasquale Longo
Bioorganic & Medicinal Chemistry Letters.2020; 30(3): 126905. CrossRef
E2F1 facilitates DNA break repair by localizing to break sites and enhancing the expression of homologous recombination factors
Eui-Hwan Choi, Keun Pil Kim
Experimental & Molecular Medicine.2019; 51(9): 1. CrossRef
Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase
Soogil Hong, Jeong H Joo, Hyeseon Yun, Nancy Kleckner, Keun P Kim
Nucleic Acids Research.2019;[Epub] CrossRef
Meiotic prophase-like pathway for cleavage-independent removal of cohesin for chromosome morphogenesis
Kiran Challa, Miki Shinohara, Akira Shinohara
Current Genetics.2019; 65(4): 817. CrossRef
Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance
Steffi Goffart, Anu Hangas, Jaakko L. O. Pohjoismäki
International Journal of Molecular Sciences.2019; 20(8): 2041. CrossRef
A Transcriptome-based Perspective of Meiosis in Dinoflagellates
David Morse
Protist.2019; 170(4): 397. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

[MINIREVIEW] The nature of meiotic chromosome dynamics and recombination in budding yeast

J. Microbiol. 2019;57(4):221-231. Published online January 22, 2019

DOI: https://doi.org/10.1007/s12275-019-8541-9

Related articles