Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth

Shimeng Huang; Na Li; Cong Liu; Tiantian Li; Wei Wang; Lili Jiang; Zhen Li; Dandan Han; Shiyu Tao; Junjun Wang

doi:10.1007/s12275-019-8690-x

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Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth: Shimeng Huang ^1,2, Na Li ^1,2, Cong Liu ¹, Tiantian Li ^1,2, Wei Wang ^1,2, Lili Jiang ¹, Zhen Li ^1,3, Dandan Han ^1,2, Shiyu Tao ^1,2, Junjun Wang ^1,2; Journal of Microbiology 2019;57(9):748-758.
DOI: https://doi.org/10.1007/s12275-019-8690-x
Published online: June 11, 2019

¹State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China, ²Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, P. R. China, ³State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100193, P. R. China

Corresponding author: Junjun Wang , Tel: +86-10-62733588,

Received: 14 December 2018 • Revised: 26 February 2019 • Accepted: 8 April 2019

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Abstract

Intrauterine growth restriction (IUGR) predisposes newborns to inflammatory and metabolic disturbance. Disequilibrium of gut microbiota in early life has been implicated in the incidence of inflammation and metabolic diseases in adulthood. This study aimed to investigate the difference in gut microbiota colonization, cytokines and plasma metabolome between IUGR and normal birth weight (NBW) piglets in early life. At birth, reduced (P < 0.05) body, jejunum, and ileum weights, as well as decreased (P < 0.05) small intestinal villi and increased (P < 0.05) ileal crypt depth were observed in IUGR piglets compared with their NBW counterparts. Imbalanced inflammatory and plasma metabolome profile was observed in IUGR piglets. Furthermore, altered metabolites were mainly involved in fatty acid metabolism and inflammatory response. At 12 h after birth and after suckling colostrum, reduced (P < 0.05) postnatal growth and the small intestinal maturation retardation (P < 0.05) continued in IUGR piglets in comparison with those in NBW littermates. Besides, the gut microbiota structure was significantly altered by IUGR. Importantly, the disruption of the inflammatory profile and metabolic status mainly involved the pro-inflammatory cytokines (IL-1β and IFN-γ) and amino acid metabolism. Moreover, spearman correlation analysis showed that the increased abundance of Escherichia-Shigella and decreased abundance of Clostridium_sensu_stricto_1 in IUGR piglets was closely associated with the alterations of slaughter weight, intestinal morphology, inflammatory cytokines, and plasma metabolites. Collectively, IUGR significantly impairs small intestine structure, modifies gut microbiota colonization, and disturbs inflammatory and metabolic profiles during the first 12 h after birth. The unbalanced gut microbiota mediated by IUGR contributes to the development of inflammation and metabolic diseases.

Keywords: intrauterine growth restriction;piglets;gut microbiota;inflammatory cytokines;plasma metabolomics

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Characteristics of the gut microbiota colonization, inflammatory profile, and plasma metabolome in intrauterine growth restricted piglets during the first 12 hours after birth

J. Microbiol. 2019;57(9):748-758. Published online June 11, 2019

DOI: https://doi.org/10.1007/s12275-019-8690-x

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