Caspase-3 inhibitor inhibits enterovirus D68 production

Wenbo Huo; Jinghua Yu; Chunyu Liu; Ting Wu; Yue Wang; Xiangling Meng; Fengmei Song; Shuxia Zhang; Ying Su; Yumeng Liu; Jinming Liu; Xiaoyan Yu; Shucheng Hua

doi:10.1007/s12275-020-0241-y

Articles

Page Path: HOME > J. Microbiol > Volume 58(9); 2020 > Article

Article
Caspase-3 inhibitor inhibits enterovirus D68 production: Wenbo Huo ^1,2, Jinghua Yu ¹, Chunyu Liu ³, Ting Wu ⁴, Yue Wang ⁵, Xiangling Meng ², Fengmei Song ², Shuxia Zhang ², Ying Su ², Yumeng Liu ², Jinming Liu ², Xiaoyan Yu ², Shucheng Hua ⁶; Journal of Microbiology 2020;58(9):812-820.
DOI: https://doi.org/10.1007/s12275-020-0241-y
Published online: September 1, 2020

¹Institute of Virology and AIDS Research, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China, ²Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Science, Jilin University, Changhun 130000, P. R. China, ³Acupuncture Department, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun 130000, P. R. China, ⁴Neonatal Intensive Care Unit, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China, ⁵Department of Chemistry of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun 130000, P. R. China, ⁶Department of Internal Medicine, The First Hospital of Jilin University, Jilin University, Changchun 130000, P. R. China

Received: 8 May 2020 • Revised: 19 June 2020 • Accepted: 22 June 2020

577 Views
1 Download
9 Web of Science
9 Crossref
9 Scopus

Article

Download PDF

Abstract

Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.

Keywords: EVD68, caspase-3, apoptosis, viral production, host-pathogen interaction

Supplementary Information

References

Citations

Citations to this article as recorded by

Non-Polio Enterovirus Inhibitors: Scaffolds, Targets, and Potency─What’s New?
Hugo Fernando Georges Roux, Franck Touret, Pascal Rathelot, Pietro Sciò, Antonio Coluccia, Patrice Vanelle, Manon Roche
ACS Infectious Diseases.2025; 11(1): 21. CrossRef
Mechanistic and target study of anthraquinone modifier KA-4c triggering endoplasmic reticulum stress to inhibit triple-negative breast cancer cells
Yingying Yang, Shumei Xu, Qiangjian Chen, Yingdan Zhao, Xinxiao Li, Junying Li, Huaxin Hou, Danrong Li
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2025; 1871(8): 168020. CrossRef
Mode of cell death in the penile cavernous tissue of type 1 diabetes mellitus rats
Jing Li, Qilan Jiang, Jun Jiang, Rui Jiang
The Journal of Sexual Medicine.2024; 21(8): 652. CrossRef
MDA5 Enhances Invasive Candida albicans Infection by Regulating Macrophage Apoptosis and Phagocytosis/Killing Functions
Yayun Chen, Qian Jiang, Furong Qing, Junxia Xue, Qiuxiang Xiao, Wenji He, Lina Sui, Zhiping Liu
Inflammation.2024; 47(1): 191. CrossRef
Caspase-8 activation regulates enterovirus D68 infection-induced inflammatory response and cell death
Yuanyuan Zhou, Chongtao Zhang, Yuhan Zhang, Fei Li, Jun Shen
Biosafety and Health.2024; 6(3): 171. CrossRef
Enterovirus D68 Infection Induces TDP-43 Cleavage, Aggregation, and Neurotoxicity
Lili Zhang, Jiaxin Yang, Huili Li, Zhe Zhang, Zhilin Ji, Lirong Zhao, Wei Wei, Rebecca Ellis Dutch
Journal of Virology.2023;[Epub] CrossRef
Inhibitory effect of tanshinone IIA, resveratrol and silibinin on enterovirus 68 production through inhibiting ATM and DNA-PK pathway
Ying Su, Ting Wu, Xiao-Yan Yu, Wen-Bo Huo, Shao-Hua Wang, Chen Huan, Yu-Meng Liu, Jin-Ming Liu, Min-Na Cui, Xin-Hua Li, Jing-Hua Yu
Phytomedicine.2022; 99: 153977. CrossRef
Urolithin A inhibits enterovirus 71 replication and promotes autophagy and apoptosis of infected cells in vitro
Shengyu Wang, Junhua Qiao, Yaping Chen, Langfei Tian, Xin Sun
Archives of Virology.2022; 167(10): 1989. CrossRef
Mst1/2-ALK promotes NLRP3 inflammasome activation and cell apoptosis during Listeria monocytogenes infection
Aijiao Gao, Huixin Tang, Qian Zhang, Ruiqing Liu, Lin Wang, Yashan Liu, Zhi Qi, Yanna Shen
Journal of Microbiology.2021; 59(7): 681. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Caspase-3 inhibitor inhibits enterovirus D68 production

J. Microbiol. 2020;58(9):812-820. Published online September 1, 2020

DOI: https://doi.org/10.1007/s12275-020-0241-y

Related articles