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Review
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Phosphate sugar isomerases and their potential for rare sugar bioconversion
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Soo-Jung Kim 1, Yeong-Su Kim 2, Soo-Jin Yeom 3
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Journal of Microbiology 2020;58(9):725-733.
DOI: https://doi.org/10.1007/s12275-020-0226-x
Published online: June 25, 2020
1Department of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea, 2Wild Plants Industrialization Research Division, Baekdudaegan National Arboretum, Bonghwa 36209, Republic of Korea, 3School of Biological Sciences and Technology, Chonnam National University, Gwangju 61186, Republic of Korea
Received: 29 April 2020 • Revised: 26 May 2020 • Accepted: 27 May 2020
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Abstract
Phosphate sugar isomerases, catalyzing the isomerization between
ketopentose/ketohexose phosphate and aldopentose/
aldohexose phosphate, play an important role in microbial
sugar metabolism. They are present in a wide range of microorganisms.
They have attracted increasing research interest
because of their broad substrate specificity and great potential
in the enzymatic production of various rare sugars. Here,
the enzymatic properties of various phosphate sugar isomerases
are reviewed in terms of their substrate specificities and
their applications in the production of valuable rare sugars because
of their functions such as low-calorie sweeteners, bulking
agents, and pharmaceutical precursor. Specifically, we
focused on the industrial applications of D-ribose-5-phosphate
isomerase and D-mannose-6-phosphate isomerase to
produce D-allose and L-ribose, respectively.
Supplementary Information
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