[MINIREVIEW]Regulation of gene expression by protein lysine acetylation in Salmonella

Hyojeong Koo; Shinae Park; Min-Kyu Kwak; Jung-Shin Lee

doi:10.1007/s12275-020-0483-8

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[MINIREVIEW]Regulation of gene expression by protein lysine acetylation in Salmonella: Hyojeong Koo ^1†, Shinae Park ^1†, Min-Kyu Kwak ², Jung-Shin Lee ¹; Journal of Microbiology 2020;58(12):979-987.
DOI: https://doi.org/10.1007/s12275-020-0483-8
Published online: November 17, 2020

¹Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea, ²Department of Food and Nutrition, College of Human Industry, Eulji University, Seongnam 13135, Republic of Korea¹Department of Molecular Bioscience, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea, ²Department of Food and Nutrition, College of Human Industry, Eulji University, Seongnam 13135, Republic of Korea

Corresponding author: Min-Kyu Kwak , Tel: +82-33-250-8549;,
Jung-Shin Lee , Tel: +82-33-250-8549;,

Received: 18 September 2020 • Revised: 12 October 2020 • Accepted: 12 October 2020

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Abstract

Protein lysine acetylation influences many physiological functions, such as gene regulation, metabolism, and disease in eukaryotes. Although little is known about the role of lysine acetylation in bacteria, several reports have proposed its importance in various cellular processes. Here, we discussed the function of the protein lysine acetylation and the post-translational modifications (PTMs) of histone-like proteins in bacteria focusing on Salmonella pathogenicity. The protein lysine residue in Salmonella is acetylated by the Pat-mediated enzymatic pathway or by the acetyl phosphate-mediated non-enzymatic pathway. In Salmonella, the acetylation of lysine 102 and lysine 201 on PhoP inhibits its protein activity and DNAbinding, respectively. Lysine acetylation of the transcriptional regulator, HilD, also inhibits pathogenic gene expression. Moreover, it has been reported that the protein acetylation patterns significantly differ in the drug-resistant and -sensitive Salmonella strains. In addition, nucleoid-associated proteins such as histone-like nucleoid structuring protein (H-NS) are critical for the gene silencing in bacteria, and PTMs in H-NS also affect the gene expression. In this review, we suggest that protein lysine acetylation and the post-translational modifications of H-NS are important factors in understanding the regulation of gene expression responsible for pathogenicity in Salmonella.

Keywords: Adaptation;Anticancer therapy;Antimutator;Genome stability;Mutation rate;Mutator phenotype;Saccharomyces cerevisiae

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[MINIREVIEW]Regulation of gene expression by protein lysine acetylation in Salmonella

J. Microbiol. 2020;58(12):979-987. Published online November 17, 2020

DOI: https://doi.org/10.1007/s12275-020-0483-8

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