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HOME > J. Microbiol > Volume 59(2); 2021 > Article
Review
Rediscovery of antimicrobial peptides as therapeutic agents
Minkyung Ryu , Jaeyeong Park , Ji-Hyun Yeom , Minju Joo , Kangseok Lee
Journal of Microbiology 2021;59(2):113-123.
DOI: https://doi.org/10.1007/s12275-021-0649-z
Published online: February 1, 2021
Department of Life Science, Chung-Ang University, Seoul 06974, Republic of KoreaDepartment of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea
Corresponding author:  Ji-Hyun Yeom , Tel: +82-2-820-5241, 
Minju Joo , Tel: +82-2-820-5241, 
Kangseok Lee , Tel: +82-2-820-5241, 
Received: 11 December 2020   • Accepted: 23 December 2020
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Abstract

In recent years, the occurrence of antibiotic-resistant pathogens is increasing rapidly. There is growing concern as the development of antibiotics is slower than the increase in the resistance of pathogenic bacteria. Antimicrobial peptides (AMPs) are promising alternatives to antibiotics. Despite their name, which implies their antimicrobial activity, AMPs have recently been rediscovered as compounds having antifungal, antiviral, anticancer, antioxidant, and insecticidal effects. Moreover, many AMPs are relatively safe from toxic side effects and the generation of resistant microorganisms due to their target specificity and complexity of the mechanisms underlying their action. In this review, we summarize the history, classification, and mechanisms of action of AMPs, and provide descriptions of AMPs undergoing clinical trials. We also discuss the obstacles associated with the development of AMPs as therapeutic agents and recent strategies formulated to circumvent these obstacles.

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    Rediscovery of antimicrobial peptides as therapeutic agents
    J. Microbiol. 2021;59(2):113-123.   Published online February 1, 2021
    DOI: https://doi.org/10.1007/s12275-021-0649-z
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