Pathogenomics of Streptococcus ilei sp. nov., a newly identified  pathogen ubiquitous in human microbiome

Dong-Wook Hyun; Jae-Yun Lee; Min-Soo Kim; Na-Ri Shin; Tae Woong Whon; Kyung Hyun Kim; Pil Soo Kim; Euon Jung Tak; Mi-Ja Jung; June Young Lee; Hyun Sik Kim; Woorim Kang; Hojun Sung; Che Ok Jeon; Jin-Woo Bae

doi:10.1007/s12275-021-1165-x

Articles

Page Path: HOME > J. Microbiol > Volume 59(8); 2021 > Article


Pathogenomics of Streptococcus ilei sp. nov., a newly identified pathogen ubiquitous in human microbiome: Dong-Wook Hyun ¹, Jae-Yun Lee ¹, Min-Soo Kim ¹, Na-Ri Shin ¹, Tae Woong Whon ¹, Kyung Hyun Kim ², Pil Soo Kim ¹, Euon Jung Tak ¹, Mi-Ja Jung ¹, June Young Lee ¹, Hyun Sik Kim ¹, Woorim Kang ¹, Hojun Sung ¹, Che Ok Jeon ², Jin-Woo Bae ¹; Journal of Microbiology 2021;59(8):793-806.
DOI: https://doi.org/10.1007/s12275-021-1165-x

Author Affiliations

¹Department of Biology, Department of Biomedical and Pharmaceutical Sciences, and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea, ²Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea¹Department of Biology, Department of Biomedical and Pharmaceutical Sciences, and Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, Seoul 02447, Republic of Korea, ²Department of Life Science, Chung-Ang University, Seoul 06974, Republic of Korea

68 Views
0 Download
9 Web of Science
9 Crossref
9 Scopus

Full Article

Abstract

Viridans group streptococci are a serious health concern because most of these bacteria cause life-threatening infections, especially in immunocompromised and hospitalized individuals. We focused on two alpha-hemolytic Streptococcus strains (I-G2 and I-P16) newly isolated from an ileostomy effluent of a colorectal cancer patient. We examined their pathogenic potential by investigating their prevalence in human and assessing their pathogenicity in a mouse model. We also predicted their virulence factors and pathogenic features by using comparative genomic analysis and in vitro tests. Using polyphasic and systematic approaches, we identified the isolates as belonging to a novel Streptococcus species and designated it as Streptococcus ilei. Metagenomic survey based on taxonomic assignment of datasets from the Human Microbiome Project revealed that S. ilei is present in most human population and at various body sites but is especially abundant in the oral cavity. Intraperitoneal injection of S. ilei was lethal to otherwise healthy C57BL/6J mice. Pathogenomics and in vitro assays revealed that S. ilei possesses a unique set of virulence factors. In agreement with the in vivo and in vitro data, which indicated that S. ilei strain I-G2 is more pathogenic than strain I-P16, only the former displayed the streptococcal group A antigen. We here newly identified S. ilei sp. nov., and described its prevalence in human, virulence factors, and pathogenicity. This will help to prevent S. ilei strain misidentification in the future, and improve the understanding and management of streptococcal infections.

Keywords: Gcn5-related N-acetyltransferases (GNATs);Salmonella-infecting phage SPN3US;acetyl-CoA

Figure & Data

References

Citations

Citations to this article as recorded by

Microbiota analysis of perimenopausal women experiencing recurrent vaginitis in conjunction with urinary tract infection
Yingying Bi, Yuezhu Wang, Wu Li, Yuhang Chen, Jinlong Qin, Huajun Zheng
BMC Microbiology.2025;[Epub] CrossRef
Characterization of blood microbial population in beef calves with clinical signs of sepsis using 16S rRNA gene sequencing
Giuliano Borriello, Flaminia Valentini, Sara Ferrini, Giorgia Di Muro, Giulia Cagnotti, Elena Grego, Angela Maria Catania, Maria Cristina Stella, Ugo Ala, Patrizia Nebbia, Antonio D’Angelo, Claudio Bellino, Ulrike Gertrud Munderloh
PLOS One.2025; 20(5): e0324469. CrossRef
Molecular characterization of a novel putative pathogen, Streptococcus nakanoensis sp. nov., isolated from sputum culture
Takeaki Wajima, Takashi Sugawara, Emi Tanaka, Kei-ichi Uchiya, Justin R. Kaspar
Microbiology Spectrum.2024;[Epub] CrossRef
Streptococcus raffinosi sp. nov., isolated from human breast milk samples
Ha Viet Nguyen, Anh Thi Van Trinh, Linh Nguyen Hai Bui, Anh Thi Lan Hoang, Quyen Thi Le Tran, Trung Thanh Trinh
International Journal of Systematic and Evolutionary Microbiology .2024;[Epub] CrossRef
Description of Streptococcus dentalis sp. nov., Streptococcus gingivalis sp. nov., and Streptococcus lingualis sp. nov., Isolated from Human Oral Cavities
Beom-Jin Goo, Young-Sik Choi, Do-Hun Gim, Su-Won Jeong, Jee-Won Choi, Hojun Sung, Jae-Yun Lee, Jin-Woo Bae
Journal of Microbiology.2024; 62(11): 973. CrossRef
Valid and accepted novel bacterial taxa derived from human clinical specimens and taxonomic revisions published in 2022
Erik Munson, Arianna Carella, Karen C. Carroll, Romney M. Humphries
Journal of Clinical Microbiology.2023;[Epub] CrossRef
Valid publication of new names and new combinations effectively published outside the IJSEM. Validation List no. 203
Aharon Oren, George M. Garrity
International Journal of Systematic and Evolutionary Microbiology .2022;[Epub] CrossRef
Modulation of gut microbiota and fecal metabolites by corn silk among high-fat diet-induced hypercholesterolemia mice
Lin Ding, Shan Ren, Yaoxin Song, Chuangang Zang, Yuchao Liu, Hao Guo, Wenqing Yang, Hong Guan, Jicheng Liu
Frontiers in Nutrition.2022;[Epub] CrossRef
Reclassification of Streptococcus ilei as a later heterotypic synonym of Streptococcus koreensis based on whole-genome sequence analysis
Sanjeet Kumar, Kanika Bansal, Santosh Kumar Sethi
Archives of Microbiology.2022;[Epub] CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Pathogenomics of Streptococcus ilei sp. nov., a newly identified pathogen ubiquitous in human microbiome

J. Microbiol. 2021;59(8):793-806.

DOI: https://doi.org/10.1007/s12275-021-1165-x

Related articles