CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion

Yun Hui Choi; Jing Lai; Myeong-A Kim; Aeryun Kim; Jinmoon Kim; Hanfu Su; Linhu Ge; Jeong-Heon Cha

doi:10.1007/s12275-021-1136-2

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CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion: Yun Hui Choi ^1†, Jing Lai ^1†, Myeong-A Kim ¹, Aeryun Kim ¹, Jinmoon Kim ¹, Hanfu Su ², Linhu Ge ², Jeong-Heon Cha ^1,2; Journal of Microbiology 2021;59(8):763-770.
DOI: https://doi.org/10.1007/s12275-021-1136-2
Published online: June 1, 2021

¹Department of Oral Biology, Oral Science Research Center, Department of Applied Life Science, the Graduate School, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea, ²Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P. R. China¹Department of Oral Biology, Oral Science Research Center, Department of Applied Life Science, the Graduate School, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul 03722, Republic of Korea, ²Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong 510182, P. R. China

Corresponding author: Hanfu Su , Tel: +82-2-2228-3061,
Linhu Ge , Tel: +82-2-2228-3061,
Jeong-Heon Cha , Tel: +82-2-2228-3061,

Received: 11 March 2021 • Revised: 6 May 2021 • Accepted: 7 May 2021

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Abstract

Helicobacter pylori colonizes human gastric mucosa. Its infection is associated with gastric diseases including gastric cancer. CagA is one of the most important toxins produced by H. pylori. It is related to gastric cancer which can be injected into host cells via a type IV secretion system (T4SS). CagL is a structural component of T4SS apparatus, which triggers host cell signaling pathway. It has been reported that CagL polymorphisms may influence the severity of disease development. To explore the contribution of CagL polymorphisms between East Asian and Western H. pylori in pathogenesis, cagL gene in G27 H. pylori was swapped by K74 cagL which is identical to East Asian CagL consensus sequence and by Western 26695 H. pylori, resulting in G27ΔcagL/cagLK74 and G27ΔcagL/cagL26695, respectively. Intriguingly, G27ΔcagL/ cagLK74 showed significantly less ability of IL-8 induction than G27ΔcagL/cagL26695 while displayed similar abilities of CagA phosphorylation, and cell elongation. Taken together, this study suggests that the CagL polymorphism may influence IL-8 induction, and K74 CagL has less ability to induce IL-8 secretion than G27 or 26695 CagL. Further research should address how the different capabilities of IL-8 induction between intraspecies-CagL are associated with the large differences of the incidence of gastric cancer between East Asian and Western countries.

Keywords: Sala cibi;halophilic archaea;polyphasic taxonomy;solar salt

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CagL polymorphisms between East Asian and Western Helicobacter pylori are associated with different abilities to induce IL-8 secretion

J. Microbiol. 2021;59(8):763-770. Published online June 1, 2021

DOI: https://doi.org/10.1007/s12275-021-1136-2

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