Activity of Lactobacillus crispatus isolated from vaginal microbiota against Mycobacterium tuberculosis

Youngkyoung Lee; Hoonhee Seo; Sukyung Kim; MD Abdur Rahim; Youjin Yoon; Jehee Jung; Saebim Lee; Chang Beom Ryu; Ho-Yeon Song

doi:10.1007/s12275-021-1332-0

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Activity of Lactobacillus crispatus isolated from vaginal microbiota against Mycobacterium tuberculosis: Youngkyoung Lee ^1†, Hoonhee Seo ^2†, Sukyung Kim ², MD Abdur Rahim ¹, Youjin Yoon ¹, Jehee Jung ¹, Saebim Lee ², Chang Beom Ryu ³, Ho-Yeon Song ^1,2; Journal of Microbiology 2021;59(11):1019-1030.
DOI: https://doi.org/10.1007/s12275-021-1332-0
Published online: November 1, 2021

¹Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 31151, Republic of Korea, ²Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan 31538, Republic of Korea, ³Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea¹Department of Microbiology and Immunology, School of Medicine, Soonchunhyang University, Cheonan 31151, Republic of Korea, ²Probiotics Microbiome Convergence Center, Soonchunhyang University, Asan 31538, Republic of Korea, ³Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon 14584, Republic of Korea

Corresponding author: Ho-Yeon Song ,

Received: 23 June 2021 • Revised: 23 September 2021 • Accepted: 29 September 2021

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Abstract

Tuberculosis, an infectious disease, is caused by Mycobacterium tuberculosis. It remains a significant public health issue around the globe, causing about 1.8 million deaths every year. Drug-resistant M. tuberculosis, including multi-drug-resistant (MDR), extremely-drug-resistant (XDR), and totally drugresistant (TDR) M. tuberculosis, continues to be a threat to public health. In the case of antibiotic-resistant tuberculosis, the treatment effect of conventional antibiotics is low. Side effects caused by high doses over a long period are causing severe problems. To overcome these problems, there is an urgent need to develop a new anti-tuberculosis drug that is different from the existing compound-based antibiotics. Probiotics are defined as live microorganisms conferring health benefits. They can be potential therapeutic agents in this context as the effectiveness of probiotics against different infectious diseases has been well established. Here, we report that Lactobacillus crispatus PMC201 shows a promising effect on tuberculosis isolated from vaginal fluids of healthy Korean women. Lactobacillus crispatus PMC201 reduced M. tuberculosis H37Rv under co-culture conditions in broth and reduced M. tuberculosis H37Rv and XDR M. tuberculosis in macrophages. Lactobacillus crispatus PMC201 was not toxic to a guinea pig model and did not induce dysbiosis in a human intestinal microbial ecosystem simulator. Taken together, these
results
indicate that L. crispatus PMC201 can be a promising alternative drug candidate in the current tuberculosis drug regime. Further study is warranted to assess the in vivo efficacy and confirm the mode of action of L. crispatus PMC201.

Keywords: Biocompatibility;Enzyme activity;Membrane damage;Polygonatum polysaccharide;Silver nanoparticles;Wound infection

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Activity of Lactobacillus crispatus isolated from vaginal microbiota against Mycobacterium tuberculosis

J. Microbiol. 2021;59(11):1019-1030. Published online November 1, 2021

DOI: https://doi.org/10.1007/s12275-021-1332-0

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