Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial

Kwangmin Kim; Karpagam Veerappan; Nahyun Woo; Bohyeon Park; Sathishkumar Natarajan; Hoyong Chung; Cheolmin Kim; Junhyung Park

doi:10.1007/s12275-021-1329-8

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Randomized Controlled Trial
Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial: Kwangmin Kim ¹, Karpagam Veerappan ¹, Nahyun Woo ¹, Bohyeon Park ¹, Sathishkumar Natarajan ¹, Hoyong Chung ¹, Cheolmin Kim ², Junhyung Park ¹; Journal of Microbiology 2021;59(12):1150-1156.
DOI: https://doi.org/10.1007/s12275-021-1329-8
Published online: October 26, 2021

¹3BIGS CO. LTD., Suwon 16506, Republic of Korea , ²Department of BioMedical Informatics, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea¹3BIGS CO. LTD., Suwon 16506, Republic of Korea , ²Department of BioMedical Informatics, School of Medicine, Pusan National University, Yangsan 50612, Republic of Korea

Corresponding author: Cheolmin Kim , Tel: +82-31-8064-1877,
Junhyung Park , Tel: +82-31-8064-1877,

Received: 21 June 2021 • Revised: 27 August 2021 • Accepted: 27 September 2021

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Abstract

The stem and root bark of Ulmus macrocarpa Hance has been used as traditional pharmacological agent against inflammation related disorders. The objective of this study was to explore the impact of Ulmus macrocarpa Hance extract (UME) on human gut microbiota. A randomized placebo-controlled clinical study was conducted in healthy adults. The study subjects were given 500 mg/day of UME or placebo orally for 4 weeks. Eighty fecal samples were collected at baseline and 4 weeks of UME or placebo intervention. The gut microbiota variation was evaluated by 16S rRNA profiling. The microbial response was highly personalized, and no statistically significant differences was observed in both species richness and abundance. The number of bacterial species identified in study subjects ranged from 86 to 182 species. The analysis for taxonomical changes revealed an increase in Eubacterium ventriosum, Blautia faecis, Ruminococcus gnavus in the UME group. Functional enrichment of bacterial genes showed an increase in primary and secondary bile acid biosynthesis in UME group. Having known from previous studies Eubacterium regulated bile acid homeostasis in protecting gut microbial architecture and immunity, we suggest that UME supplementation might enhance host immunity by modulating gut microbiota. This is the first stage study and forthcoming clinical studies with larger participants are needed to confirm these findings.

Keywords: 16S rRNA;bioinformatics;microbiome;next-generation sequencing;software pipeline

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Ulmus macrocarpa Hance extract modulates intestinal microbiota in healthy adults: a randomized, placebo-controlled clinical trial

J. Microbiol. 2021;59(12):1150-1156. Published online October 26, 2021

DOI: https://doi.org/10.1007/s12275-021-1329-8

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