Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway

Taehwan Park; Jintaek Im; A Reum Kim; Dongwook Lee; Sungho Jeong; Cheol-Heui Yun; Seung Hyun Han

doi:10.1007/s12275-021-1576-8

Articles

Page Path: HOME > J. Microbiol > Volume 59(12); 2021 > Article

Journal Article
Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway: Taehwan Park ¹, Jintaek Im ¹, A Reum Kim ¹, Dongwook Lee ¹, Sungho Jeong ¹, Cheol-Heui Yun ^2,3, Seung Hyun Han ¹; Journal of Microbiology 2021;59(12):1142-1149.
DOI: https://doi.org/10.1007/s12275-021-1576-8
Published online: December 4, 2021

¹Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea, ²Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea, ³Institutes of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea¹Department of Oral Microbiology and Immunology, and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 08826, Republic of Korea, ²Department of Agricultural Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea, ³Institutes of Green Bio Science and Technology, Seoul National University, Pyeongchang 25354, Republic of Korea

Corresponding author: Seung Hyun Han , Tel: +82-2-880-2310,

Received: 3 November 2021 • Revised: 12 November 2021 • Accepted: 12 November 2021

prev next

60 Views
0 Download
15 Web of Science
17 Crossref
16 Scopus

Full Article

Abstract

Streptococcus gordonii, a Gram-positive commensal bacterium, is an opportunistic pathogen closely related to initiation and progression of various oral diseases, such as periodontitis and dental caries. Its biofilm formation is linked with the development of such diseases by enhanced resistance against antimicrobial treatment or host immunity. In the present study, we investigated the effect of short-chain fatty acids (SCFAs) on the biofilm formation of S. gordonii. SCFAs, including sodium acetate (NaA), sodium propionate (NaP), and sodium butyrate (NaB), showed an effective inhibitory activity on the biofilm formation of S. gordonii without reduction in bacterial growth. SCFAs suppressed S. gordonii biofilm formation at early time points whereas SCFAs did not affect its preformed biofilm. A quorum-sensing system mediated by competence-stimulating peptide (CSP) is known to regulate biofilm formation of streptococci. Interestingly, SCFAs substantially decreased mRNA expression of comD and comE, which are CSP-sensor and its response regulator responsible for CSP pathway, respectively. Although S. gordonii biofilm formation was enhanced by exogenous synthetic CSP treatment, such effect was not observed in the presence of SCFAs. Collectively, these results suggest that SCFAs have an anti-biofilm activity on S. gordonii through inhibiting comD and comE expression which results in negative regulation of CSP quorum-sensing system. SCFAs could be an effective anti-biofilm agent against S. gordonii for the prevention of oral diseases.

Keywords: LasB;Pseudomonas aeruginosa;elastase;propeptide;protease;protease inhibition;protein stability

Figure & Data

References

Citations

Citations to this article as recorded by

Potential effects of prebiotic fibers on dental caries: a systematic review
Constanza E. Fernández, Catalina Maturana‐Valenzuela, Nicol Rojas‐Castillo, Bob Rosier
Journal of the Science of Food and Agriculture.2025;[Epub] CrossRef
Serotype-Dependent Inhibition of Streptococcus pneumoniae Growth by Short-Chain Fatty Acids
Suwon Lim, Dongwook Lee, Sungho Jeong, Jeong Woo Park, Jintaek Im, Bokeum Choi, Donghyun Gwak, Cheol-Heui Yun, Ho Seong Seo, Seung Hyun Han
Journal of Microbiology and Biotechnology.2024; 34(1): 47. CrossRef
Comprehensive Multi-Omic Evaluation of the Microbiota and Metabolites in the Colons of Diverse Swine Breeds
Yanbin Zhu, Guangming Sun, Yangji Cidan, Bin Shi, Zhankun Tan, Jian Zhang, Wangdui Basang
Animals.2024; 14(8): 1221. CrossRef
Recent progress in understanding the role of bacterial extracellular DNA: focus on dental biofilm
Fengxue Geng, Junchao Liu, Jinwen Liu, Ze Lu, Yaping Pan
Critical Reviews in Microbiology.2024; : 1. CrossRef
Effects of Epigallocatechin gallate on Biofilm adherence and Glycolytic pH in Streptococcus gordonii
Prawati Nuraini, Dimas Prasetianto Wicaksono, Ardianti Maartrina Dewi, Adinda Ayu Fitriana, Sili Han
Research Journal of Pharmacy and Technology.2024; : 4711. CrossRef
Oral Pathogens and Their Antibiotics from Marine Organisms: A Systematic Review of New Drugs for Novel Drug Targets
Sehyeok Im, Jun Hyuck Lee, Youn-Soo Shim
Journal of Dental Hygiene Science.2024; 24(2): 84. CrossRef
Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis
Menghe Liu, Ru Peng, Chunfang Tian, Jianping Shi, Jiannan Ma, Ruiwen Shi, Xiao Qi, Rongwei Zhao, Haibin Guan
Frontiers in Cellular and Infection Microbiology.2024;[Epub] CrossRef
Butyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition
Ok-Jin Park, Ye-Eun Ha, Ju-Ri Sim, Dongwook Lee, Eun-Hye Lee, Sun-Young Kim, Cheol-Heui Yun, Seung Hyun Han
Cell Death Discovery.2023;[Epub] CrossRef
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases
María José Mendoza-León, Ashutosh K. Mangalam, Alejandro Regaldiz, Enrique González-Madrid, Ma. Andreina Rangel-Ramírez, Oscar Álvarez-Mardonez, Omar P. Vallejos, Constanza Méndez, Susan M. Bueno, Felipe Melo-González, Yorley Duarte, Ma. Cecilia Opazo, Al
Frontiers in Endocrinology.2023;[Epub] CrossRef
Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases
Yumeng Wang, Shixi Xu, Qiurong He, Kun Sun, Xiaowan Wang, Xiaorui Zhang, Yuqing Li, Jumei Zeng
Frontiers in Microbiology.2023;[Epub] CrossRef
Listening to enteric bacteria from the perspective of antibiotic alternatives in animal husbandry
Leli Wang, Yiru Zhang, Juan Xu, Qingqing Shi, Yao Peng, Cimin Long, Lan Li, Yulong Yin
The Innovation Life.2023; 1(2): 100022. CrossRef
The Complicated Relationship of Short-Chain Fatty Acids and Oral Microbiome: A Narrative Review
Georgy E. Leonov, Yurgita R. Varaeva, Elena N. Livantsova, Antonina V. Starodubova
Biomedicines.2023; 11(10): 2749. CrossRef
Social networking at the microbiome-host interface
Richard J. Lamont, George Hajishengallis, Hyun Koo, Anthony R. Richardson
Infection and Immunity.2023;[Epub] CrossRef
Making Sense of Quorum Sensing at the Intestinal Mucosal Interface
Friederike Uhlig, Niall P. Hyland
Cells.2022; 11(11): 1734. CrossRef
Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation
Kirsi Savijoki, Paola San-Martin-Galindo, Katriina Pitkänen, Minnamari Edelmann, Annika Sillanpää, Cim van der Velde, Ilkka Miettinen, Jayendra Z. Patel, Jari Yli-Kauhaluoma, Mataleena Parikka, Adyary Fallarero, Pekka Varmanen
Foods.2022; 12(1): 90. CrossRef
Innate immunity and microbial dysbiosis in hidradenitis suppurativa – vicious cycle of chronic inflammation
Divya Chopra, Rachel A. Arens, Watcharee Amornpairoj, Michelle A. Lowes, Marjana Tomic-Canic, Natasa Strbo, Hadar Lev-Tov, Irena Pastar
Frontiers in Immunology.2022;[Epub] CrossRef
Drugs for the Quorum Sensing Inhibition of Oral Biofilm: New Frontiers and Insights in the Treatment of Periodontitis
Alessandro Polizzi, Martina Donzella, Giada Nicolosi, Simona Santonocito, Paolo Pesce, Gaetano Isola
Pharmaceutics.2022; 14(12): 2740. CrossRef

Cite this Article

Cite this Article: export Copy Download Format; Close

Download Citation

Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

Format:

RIS — For EndNote, ProCite, RefWorks, and most other reference management software
BibTeX — For JabRef, BibDesk, and other BibTeX-specific software

Include:

Citation for the content below
Citation and abstract for the content below

Short-chain fatty acids inhibit the biofilm formation of Streptococcus gordonii through negative regulation of competence-stimulating peptide signaling pathway

J. Microbiol. 2021;59(12):1142-1149. Published online December 4, 2021

DOI: https://doi.org/10.1007/s12275-021-1576-8

Related articles