A split face study on the effect of an anti-acne product containing fermentation products of Enterococcus faecalis CBT SL-5 on skin microbiome modification and acne improvement

Hye Sung Han; Sun Hye Shin; Bo-Yun Choi; Nayeon Koo; Sanghyun Lim; Dooheon Son; Myung Jun Chung; Kui Young Park; Woo Jun Sul

doi:10.1007/s12275-022-1520-6

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Randomized Controlled Trial
A split face study on the effect of an anti-acne product containing fermentation products of Enterococcus faecalis CBT SL-5 on skin microbiome modification and acne improvement: Hye Sung Han ¹, Sun Hye Shin ¹, Bo-Yun Choi ², Nayeon Koo ¹, Sanghyun Lim ³, Dooheon Son ³, Myung Jun Chung ³, Kui Young Park ¹, Woo Jun Sul ²; Journal of Microbiology 2022;60(5):488-495.
DOI: https://doi.org/10.1007/s12275-022-1520-6
Published online: March 14, 2022

¹Department of Dermatology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea, ²Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea, ³R&D Center, Cell Biotech, Co., Ltd., Gimpo 10003, Republic of Korea¹Department of Dermatology, Chung-Ang University College of Medicine, Seoul 06974, Republic of Korea, ²Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea, ³R&D Center, Cell Biotech, Co., Ltd., Gimpo 10003, Republic of Korea

Corresponding author: Kui Young Park , Tel: +82-31-670-4707;,
Woo Jun Sul , Tel: +82-31-670-4707;,

Received: 6 October 2021 • Revised: 13 January 2022 • Accepted: 19 January 2022

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Abstract

Antibiotic-resistant Cutibacterium acnes and dysbiosis of the skin microbiome are of increasing concern in acne treatment. Enterococcus faecalis, a widely used probiotic, has shown benefits for acne treatment by exerting antimicrobial activity against C. acnes. Therefore, this study aimed to investigate the efficacy and safety of an E. faecalis CBT SL-5-extract-containing lotion in patients with mild-to-moderate acne. Twenty patients were enrolled in this randomized, placebo-controlled, split-face comparative study. Patients were treated with E. faecalis lotion on one side of the face and a vehicle lotion on the other side for 4 weeks. The efficacy outcome measures included improvement in the investigators’ assessment of acne severity, patient satisfaction, changes in skin parameters and diversity of the skin microbiome. The investigators’ assessment score was significantly improved on the test side compared to the control side, after 2 weeks (p = 0.009) and 6 weeks (p < 0.0005). However, TEWL and skin hydration were not significantly different between the two groups. The phylogenetic diversity of the skin microbiota decreased over time in the skin samples of test side. In conclusion, E. faecalis CBT SL-5 extract can be a feasible and well-tolerated option for improving acne severity and skin microbiome dysbiosis in mild-to-moderate acne patients.

Keywords: 16S rRNA;Alteration;FMT;Gut microbiota;Polycystic ovary syndrome

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A split face study on the effect of an anti-acne product containing fermentation products of Enterococcus faecalis CBT SL-5 on skin microbiome modification and acne improvement

J. Microbiol. 2022;60(5):488-495. Published online March 14, 2022

DOI: https://doi.org/10.1007/s12275-022-1520-6

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