Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment

Sung Min Won; Na Young Lee; Ki&#; Haripriya Gupta; Satya Priya Sharma; Kyung Hwan Kim; Byoung Kook Kim; Hyun Chae Joung; Jin Ju Jeong; Raja Ganesan; Sang Hak Han; Sang Jun Yoon; Dong Joon Kim; Ki Tae Suk

doi:10.1007/s12275-023-00014-y

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Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment: Sung Min Won ¹, Na Young Lee ¹, Ki&# ^{8209;Kwang Oh1}, Haripriya Gupta ¹, Satya Priya Sharma ¹, Kyung Hwan Kim ², Byoung Kook Kim ², Hyun Chae Joung ², Jin Ju Jeong ¹, Raja Ganesan ¹, Sang Hak Han ³, Sang Jun Yoon ¹, Dong Joon Kim ¹, Ki Tae Suk ¹; Journal of Microbiology 2023;61(2):245-257.
DOI: https://doi.org/10.1007/s12275-023-00014-y
Published online: February 6, 2023

¹Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of Korea, ²Chong Kun Dang Bio Research Institute, Ansan, Republic of Korea, ³Department of Pathology, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea¹Institute for Liver and Digestive Diseases, Hallym University, Chuncheon 24252, Republic of Korea, ²Chong Kun Dang Bio Research Institute, Ansan, Republic of Korea, ³Department of Pathology, Hallym University College of Medicine, Chuncheon 24252, Republic of Korea

Corresponding author: Ki Tae Suk ,

Received: 4 August 2022 • Revised: 18 November 2022 • Accepted: 21 December 2022

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Abstract

The progression and exacerbation of liver fibrosis are closely related to the gut microbiome. It is hypothesized that some probiotics may slow the progression of liver fibrosis. In human stool analysis [healthy group (n = 44) and cirrhosis group (n = 18)], difference in Lactobacillus genus between healthy group and cirrhosis group was observed. Based on human data, preventive and therapeutic effect of probiotics Lactobacillus lactis and L. rhamnosus was evaluated by using four mice fibrosis models. L. lactis and L. rhamnosus were supplied to 3,5-diethoxycarbonyl-1,4-dihydrocollidine or carbon tetrachloride-induced liver fibrosis C57BL/6 mouse model. Serum biochemical measurements, tissue staining, and mRNA expression in the liver were evaluated. The microbiome was analyzed in mouse cecal contents. In the mouse model, the effects of Lactobacillus in preventing and treating liver fibrosis were different for each microbe species. In case of L. lactis, all models showed preventive and therapeutic effects against liver fibrosis. In microbiome analysis in mouse models administered Lactobacillus, migration and changes in the ratio and composition of the gut microbial community were confirmed. L. lactis and L. rhamnosus showed preventive and therapeutic effects on the progression of liver fibrosis, suggesting that Lactobacillus intake may be a useful strategy for prevention and treatment.

Keywords: environmental water;geographic isolation;livestock;norovirus;phylogeography;porcine

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Gut Lactobacillus and Probiotics Lactobacillus lactis/rhamnosis Ameliorate Liver Fibrosis in Prevention and Treatment

J. Microbiol. 2023;61(2):245-257. Published online February 6, 2023

DOI: https://doi.org/10.1007/s12275-023-00014-y

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